Squamous Cell Carcinoma Arising from Hypertrophic Lichen Planus

Jayaraman, Murugaiya; Janaki, V R; Yesudian, Patrick

doi:10.1111/j.1365-4362.1995.tb04386.x

Cited by 14 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One such marker could be the presence of areas of depigmentation in the lesions. Such lesions have increased probability to turn malignant [5]. Depigmentation was present on our case too.…”

Section: Discussionsupporting

confidence: 50%

See 1 more Smart Citation

Carcinoma in cutaneous Lichen Planus

Shetty¹,

Lamba²,

Gulur³

et al. 2013

Our Dermatol Online

View full text Add to dashboard Cite

Carcinoma occurring in the cutaneous lesions of Lichen Planus though rarely mentioned in literature does occur and should be kept in mind while treating such lesions. We report a 16 year female who developed a squamous cell carcinoma in a long standing verrucous lichen planus in the lower leg. This case is being presented to indicate the possibility of malignant transformation of cutaneous lichen planus to carcinoma, especially in the hypertrophic forms and the need to have an early diagnosis so that it can be treated in the initial stages. A high degree of suspicion should be present whenever we come across a non healing lesion in a patient with lichen planus. A few markers, which may give us a clue for increased chances of malignant transformation in these cases is presented. IntroductionLichen planus is a common papulo-squamous disorder affecting about 1-2% of the population. Lichen planus several forms. It can affect the oral mucosa, skin, nails and genatalia. Cutaneous lichen planus may affect any area but it is often seen on the front of the wrists, lower back, and ankles. Usually the lesions near the ankle are scaly and itchy and form the hypertrophic variant. New lesions occur when the old lesions are clearing. When the lesions cleared they are often replaced by greyish brown discolouration especially in dark skinned individuals. Usually these lesions heal with the conventional treatment. Neoplastic transformation in lichen planus has been described, especially in the oral form of the disease where an estimated 0.3-3% of patients may develop squamous cell carcinoma. Malignancy though uncommon with cutaneous lichen planus has been described in chronic hypertrophic lesions of lichen planus on the legs [3][4][5].

show abstract

“…One such marker could be the presence of areas of depigmentation in the lesions. Such lesions have increased probability to turn malignant [5]. Depigmentation was present on our case too.…”

Section: Discussionsupporting

confidence: 50%

“…Neoplastic transformation in lichen planus has been described, especially in the oral form of the disease where an estimated 0.3-3% of patients may develop squamous cell carcinoma. Malignancy though uncommon with cutaneous lichen planus has been described in chronic hypertrophic lesions of lichen planus on the legs [3][4][5]. …”

mentioning

confidence: 99%

Carcinoma in cutaneous Lichen Planus

Shetty¹,

Lamba²,

Gulur³

et al. 2013

Our Dermatol Online

View full text Add to dashboard Cite

show abstract

“…Hypertrophic lichen planus is a subacute chronic variant of lichen planus characterized by hypertrophic or warty lesions most often found on the pretibial area of the lower limbs 1–3 . In the literature, 41 cases of lichen planus, mainly of hypertrophic or verrucous type, with consecutive carcinoma have been described 4–8 . X‐ray and arsenic treatment of lichen ruber often precedes malignant transformation by many years 5 .…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma as a complication of long‐standing hypertrophic lichen planus

2004

View full text Add to dashboard Cite

“…In its most severe forms, hypertrophic LP mimics well‐differentiated squamous cell carcinoma (SCC). This is further complicated by reports of SCC and keratoacanthoma arising in hypertrophic LP …”

mentioning

confidence: 99%