Squamous cell carcinoma arising from hypertrophic lichen planus

Singh, SK; Saikia, UN; Ajith, C; Kumar, B. Praveen

doi:10.1111/j.1468-3083.2006.01500.x

Cited by 32 publications

(18 citation statements)

References 11 publications

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“…In this study, only six SCCs of the skin were observed in an average period of 9.9 years 3. The incidence of SCC associated with cutaneous LP is estimated to be 0.4% 2. More than 56% of the malignant neoplasms reported in cutaneous LP lesions arise in the hypertrophic variant of LP below the knee, similar to our case 2–10.…”

Section: Discussionsupporting

confidence: 85%

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Squamous cell carcinoma arising in hypertrophic lichen planus

et al. 2018

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Hypertrophic lichen planus (HLP) is a chronic T-cell-mediated inflammatory disease characterised by pruritic hypertrophic or verrucous plaques on the lower limbs. We report a case of an 87-year-old woman with a 12-year history of HLP on both lower legs presenting with malignant transformation of one lesion into a squamous cell carcinoma (SCC). Malignancy developing in cutaneous lichen planus is rare, with less than 50 cases reported in the literature. This case highlights the need to be aware of suspicious changes in long-standing HLP to allow early detection of a developing SCC.

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Section: Discussionsupporting

confidence: 85%

“…The incidence of squamous cell carcinoma (SCC) developing in cutaneous LP is estimated to be 0.4% 2. The majority of cutaneous SCC occurs in the hypertrophic type of LP located on the lower limbs 2–5.…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma arising in hypertrophic lichen planus

et al. 2018

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“…Du Castell berichtete 1903 zum ersten Mal über einen Patienten, bei dem ein spinozelluläres Karzinom bei kutanem Lichen ruber auftrat [12]. Seitdem sind einschließlich unserer 3 Fälle 91 Fälle bekannt [2,7,8,9,10,13,15,16,18,20,21,23,26,27,30,32,34,35,36,37,38,42]. Unser Literaturrückblick verweist auf 88 weitere Fälle weltweit.…”

Section: Tab 1 Darstellung Von Kutanem Lichen Ruber Planus Mit üBergunclassified

Verruköses spinozelluläres Karzinom auf Lichen ruber hypertrophicus

et al. 2010

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Lichen planus is a chronic mucocutaneous T-cell-mediated disease, whose cause is still unknown. The first case of lichen planus that transformed into squamous cell carcinoma was reported in 1903. We present three patients in whom squamous cell carcinomas were identified in chronic lichen planus. The world literature includes at least 91 cases, including our three cases. In an epidemiological study, no significant risk of transformation of cutaneous lichen planus into squamous cell carcinomas was found. In contrast, there is a significantly higher risk of malignant transformation in mucosal lichen planus, so that the WHO had graded mucosal lichen planus as a premalignant condition.

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“…Inflammoscopy can, therefore, contribute to the early recognition and treatment of HLP, which is important considering the possible development of squamous cell carcinoma in longstanding, nontreated lesions, 2 hence, its possible role also in the monitoring of these patients.…”

Section: Key Messagementioning

confidence: 99%

Inflammoscopy in the diagnosis of hypertrophic lichen planus

Sousa

Oliveira

2015

Journal of the American Academy of Dermatology

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A 43-year-old woman presented with a 2-year history of pruritic, thick, brown, hyperkeratotic plaques located on the legs (Fig 1). DERMOSCOPIC APPEARANCERound and reticular whitish structures, some with thin arboriform projections were seen using contact, dry dermoscopy. The use of alcohol as immersion liquid found multiple large comedolike openings filled with round, yellowish keratin material, resembling oil drops within a brown background. Chalk-white structureless areas were also observed (Fig 2).

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Squamous cell carcinoma arising from hypertrophic lichen planus

Cited by 32 publications

References 11 publications

Squamous cell carcinoma arising in hypertrophic lichen planus

Squamous cell carcinoma arising in hypertrophic lichen planus

Verruköses spinozelluläres Karzinom auf Lichen ruber hypertrophicus

Inflammoscopy in the diagnosis of hypertrophic lichen planus

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