Verruköses spinozelluläres Karzinom auf Lichen ruber hypertrophicus

Friedl, Tanja; Flaig, Michael J.; Ruzicka, Thomas; Rupec, Rudolf A.

doi:10.1007/s00105-010-1961-4

Cited by 12 publications

(3 citation statements)

References 38 publications

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“…In the meta-analysis of Sigurgeirsson and Lindelöf (1991) 36 reports of SCC associated with lichen planus were analysed among 2071 lichen planus patients [10]. In 2011, Friedl et al reported on three patients who developed an SCC on chronic lichen planus of the lower leg and analysed another 24 cases within five years [11]. Five more cases have been reported since then in the international literature, mostly on lower legs and in association with hypertrophic or verrucous lichen planus [12], [13], [14], [15], [16].…”

Section: Discussionmentioning

confidence: 99%

Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review

Wollina¹,

Krönert²,

Schönlebe³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: Cutaneous squamous cell carcinoma (SCC) is the second most common malignancy of skin. Although a major risk factor is a chronic exposure to ultraviolet radiation, preexistent chronic inflammatory disorders may also possess an increased risk for SCC. That is not the case for cutaneous lichen planus in contrast to oral lichen planus and oral SCC. CASE REPORT: We report the case of an 87-year-old Caucasian woman presenting with a giant verrucous tumour on the left ankle. She suffered from long-standing disseminated lichen planus. Histology confirmed the diagnosis of SCC on partly verrucous lichen planus. The course was complicated due to sepsis. An emergency transfemoral amputation became necessary. The patients survived and could be released into her nursery. A literature review underlined the rarity of SCC on lichen planus of the skin. Most of these rare cases were in patients in their second half of life on the lower legs. Hypertrophic lichen plnaus was overrepresented. CONCLUSIONS: Although very rare by number, SCC can complicate lichen planus and lead to the life-threatening situation. Atypical verrucous lesions on lichen planus warrant a histologic analysis. Surgery is the treatment of choice for cutaneous SCC.

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Section: Discussionmentioning

confidence: 99%

Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review

Wollina¹,

Krönert²,

Schönlebe³

et al. 2019

Open Access Maced J Med Sci

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“…4 There are reports of metastatic squamous cell carcinoma and keratoacanthoma arising from long standing hypertrophic lesions of lichen planus. 6,7 The morphology can be very varied ranging from hyperkeratotic papules to extremely thick plaque type of lesions.…”

Section: Discussionmentioning

confidence: 99%

Verrucous lichen planus: a rare presentation of a common condition

2014

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“…Since 1903 over 90 cases of malignant transformation of cutaneous LP into squamous cell carcinoma have been described, with a higher incidence in hypertrophic LP and the possibility to metastasize [94,95]. In oral LP a higher risk has been proven and the WHO defines oral LP as a ‘premalignant condition' [96,97].…”

Section: Discussionmentioning

confidence: 99%

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

Kolios¹,

Maggio²,

Gubler

et al. 2013

Dermatology

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Background: Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP. Objective: We present the unique case of a patient with cutaneous, oral and esophageal LP which was refractory to classical treatment options (topical clobetasol propionate and pimecrolimus, intramuscular triamcinolone acetonide); because of systemic side effects the patient did not tolerate systemic acitretin dosed up to 25 mg daily. Methods: Oral alitretinoin was used at a dose of 30 mg daily. Results: Both oral and skin changes as well as dysphagia completely resolved within 4 weeks without any severe side effects and the drug was used for 6 months. No papules, intraoral striae or dysphagia recurred during the 6 months of treatment. After 4 months the patient relapsed with mucosal patches so that a second cycle was initiated for 6 months where oral LP lesions resolved after 4 weeks also (with sporadic mild headache). Conclusion: Further studies are needed to better understand the impact of alitretinoin in LP. Our observation suggests alitretinoin as a new, well-tolerated treatment option for esophageal LP after failed response to conventional treatments.

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Verruköses spinozelluläres Karzinom auf Lichen ruber hypertrophicus

Cited by 12 publications

References 38 publications

Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review

Giant Squamous Cell Carcinoma on Chronic Lichen Planus on the Ankle - A Case Report and Short Literature Review

Verrucous lichen planus: a rare presentation of a common condition

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

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