Squamous Cell Carcinoma in a Müllerian Duct Cyst

Szemes, George C.; Rubin, Daniel J.

doi:10.1016/s0022-5347(17)62469-8

Cited by 30 publications

(11 citation statements)

References 14 publications

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“…5 Furthermore, a small but significant number of reports describe the development of malignant carcinoma from MDRs. 6 Several surgical techniques have been advocated to access the retroprostatic space and remove MDRs. In 1994 the laparoscopic approach to excise an MDC in a man was described, preserving continence and potency.…”

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confidence: 99%

Laparoscopic Removal of Müllerian Duct Remnants in Boys

et al. 2004

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Purpose: Mü llerian duct remnants (MDRs) are present in a male pseudohermaphroditic form characterized by failure of the mü llerian duct to regress due to insufficient production or peripheral action of mü llerian inhibiting substance. The MDR can be asymptomatic but it often results in infections, stones and voiding troubles. Furthermore, it may develop into a neoplasm. Therefore, surgery is mandatory for large MDRs and symptomatic patients. Laparoscopic removal is described.Materials and Methods: Six males were treated from February 1998 to February 2003. Age at surgery was between 3 and 18 years (mean 8.6). All patients showed severe hypospadias and 2 had mixed gonadal dysgenesis with ambiguous genitalia. Three patients presented with urogenital infections and all had a large MDR. Laparoscopic procedures, which were preceded by cystoscopy, were performed using a 10 mm umbilical trocar for the camera and 3, 5 mm trocars for instruments placed in the suprapubic region and iliac fossa bilaterally. The remnants were ligated with endoscopic loops or an endoscopic GIA stapler and cut.Results: Mean operative time was 2 hours. We noted no complications. In 2 cases there was deferential ectopia and in another of mixed gonadal dysgenesis bilateral gonadectomy was performed because of the risk of degeneration. Feeding started on postoperative day 1 and the patients were discharged home on day 5. After a followup of 8 months to 4 years all boys were healthy.Conclusions: Multiple approaches are used in traditional surgery, often leading to complications. Laparoscopy improves the view, decreases surgical risk and operative time, avoids large scars and allows more rapid hospital discharge.

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confidence: 99%

Laparoscopic Removal of Müllerian Duct Remnants in Boys

et al. 2004

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“…Clinically, seminal vesicular cysts should be distinguished from both müllerian duct cysts and prostatic cysts. The former are usually located at the midline between the bladder and the rectum, being often linked with urogenital abnormalities such as hypospadia, while the latter are located laterally 13,14 . Although the present case was not examined by seminal vesiculography, findings for the tumor location and histology indicated a left seminal vesicular origin 15 .…”

Section: Discussionmentioning

confidence: 58%

Squamous cell carcinoma arising from a seminal vesicular cyst: Possible relationship between chronic inflammation and tumor development

Yanagisawa¹,

Saegusa²,

Yoshida³

et al. 2002

Pathology International

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A case of squamous cell carcinoma arising within an acquired seminal vesicular cyst is described. A 61-year-old man was hospitalized because of hemospermia and dysuria. Under the diagnosis of a left seminal vesicular cyst, surgical resection was performed. Pathological examination revealed squamous cell carcinoma within a seminal vesicular cyst, along with squamous metaplastic foci and severe chronic inflammation. Cell proliferation, determined with reference to MIB-1 labeling indices, showed a stepwise increase from normal columnar epithelium, through squamous metaplasia, to squamous cell carcinoma. Sporadic p53 protein accumulation without evident gene mutations was also apparent in both the carcinoma and squamous metaplastic lesions. We therefore concluded that the squamous cell carcinoma might have developed from squamous metaplastic foci associated with chronic inflammatory stimulation, within a seminal vesicular cyst.

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“…Müllerian duct cysts commonly contain cal-culi. There have been case reports of müllerian duct cysts and prostatic utricle cysts containing carcinoma [4,5]. Not all cystic lesions located at the midline of the prostate are müllerian duct cysts or prostatic utricle cysts, and the possibility of other cystic lesions should also be considered [6].…”

Section: Intraprostatic Cystic Lesions Müllerian Duct Cysts and Prostmentioning

confidence: 99%