Squamous cell carcinoma of buccal mucosa: An analysis of prognostic factors

Bobdey, Saurabh; Sathwara, Jignasa; Jain, Abhishek; Saoba, Sushma; Ganesh, B

doi:10.4103/sajc.sajc_317_16

Cited by 44 publications

(29 citation statements)

References 41 publications

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“…A In that study, floor of the mouth and oral tongue represented the most common disease subsites, followed in descending order by gums, retromolar trigone, buccal mucosa, and hard palate [14]. In regions of China, South East Asia, and India, however, carcinoma of the buccal mucosa is one of the most common forms of OSCC [15][16][17] . The difference in the predominant sites of occurrence of cancers may largely be related to various habits prevalent in the respective regions, such as the incidence of OSCC of the buccal mucosa results from the endemic regional practice of chewing betel quid.…”

Section: Discussionmentioning

confidence: 90%

Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China—a 10-year continuous single-center study

2020

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Background: This study aimed to describe some of the characteristics of the inhabitants of Beijing with oral and oropharyngeal squamous cell carcinoma (OSCC) who had received treatment at the Stomatology Hospital of Peking University and to analyze the survival rate and the prognostic factors of patients following surgical treatment. Methods: Data for 603 consecutive cases with primary OSCC between 2004 and 2013 were obtained from the Stomatology Hospital of Peking University. Clinical data including age, sex, living district, primary tumor site, TNM stage, history of drinking and smoking, pathological differentiation, treatment, and survival were retrospectively analyzed. Results: The male:female ratio was 1.1:1. The frequency of site involvement in descending order was tongue (34.3%), gingiva (25.0%), buccal mucosa (13.8%), oral floor (9.0%), oropharynx (8.5%), lip (6.3%) and palate (3.2%). Female OSCC patients tended to be significantly older than men with OSCC (P < 0.05). The percentage of patients with TNM stage III-IV OSCC was 52.4%. The results revealed that 65.3% of male patients and only 6.3% of female patients smoked or drank. The overall 5-year survival rate was 64%. Female patients had a worse prognosis than male patients. Among the patients who received surgery, tumor size and lymph node involvement were independent prognostic factors. Smoking and drinking were not prognostic factors. Conclusion: Among the Beijing inhabitants who were diagnosed with OSCC and treated in our hospital in the past 10 years, more than half were in the advanced stage, and the cancer stage was the main prognostic factor of oral cancer. Therefore, the recognition of oral cancer should be strengthened, and early detection and treatment of OSCC should be achieved to improve the survival rate.

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Section: Discussionmentioning

confidence: 90%

Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China—a 10-year continuous single-center study

2020

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“…Loco-regional metastasis of OSCC to cervical lymph nodes is a very important prognostic factor. The number and size of affected lymph nodes, extra capsular spread and the extent of involvement of the neck, all contribute in determining the prognosis of a patient with oral carcinoma ( 8 ). Staging of patients is done also to define the need for adjuvant therapy in OSCC cases after surgery, because it is proven that in patients with pN+ post-operative radiotherapy reduces chances of recurrence ( 9 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Cervical lymph node metastasis in squamous cell carcinoma of the buccal mucosa: a retrospective study on pattern of involvement and clinical analysis

Hoda

Bc²,

Ghosh³

et al. 2021

Med Oral

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“…Cervical lymph node metastasis is the main mode of metastasis in various stages of oral cancer, and it is also an important factor affecting the prognosis of oral cancer. The number and size of metastatic lymph nodes, whether or not the capsular invasion, and the extent of involvement of the neck region will directly affect the prognosis of patients 11. Studies have shown that 50% of patients with oral cancer have lymph node metastasis at the first visit 12.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China

Li¹,

Liu²,

Yuan³

et al. 2019

J. Cancer

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Objective : To explore the risk factors of cervical lymph node metastasis in oral squamous cell carcinoma (OSCC) patients with clinical negative cervical lymph nodes(cN0) and provide a reference for clinical treatment. Methods : The clinical data of 161 OSCC patients with cN0 were retrospectively analyzed. All patients underwent extended primary resection combined with cervical lymph node dissection. The level and number of cervical lymph node metastasis were confirmed by postoperative pathology. The risk factors of cervical lymph node metastasis in patients were analyzed by univariate and multivariate Logistic regression analysis. Results : Thirty-one out of 161 cases (19%) were confirmed cervical lymph node metastasis. Among them, there were 28 cases of lymph node metastasis in one cervical level and 3 cases in two cervical levels. A total of 42 positive lymph nodes were detected in 34 cervical levels. The level number of positive areas in the IA, IB, IIA, IIB, III, IV and V levels was 2, 15, 12, 1, 4,0, and 0, respectively. The corresponding regional metastasis rates were 5.9%, 44.1%, 35.3%, 2.9%, 11.8%, 0% and 0%, respectively. The number of positive lymph node metastases in the corresponding levels were 2, 17, 17, 1, 5, 0, and 0 respectively. Univariate analysis showed that gender, age, lesion location, T stage, and perineural invasion/lymphvascular invasion (PNI/PVI) had no significant effect on cervical lymph node metastasis ( P >0.05). The growth pattern, degree of differentiation, depth of invasion, neutrophil/lymphocyte ratio (NLR) and the short/long axis diameter ratio (S/L ratio) of lymph nodes were important factors influencing the cervical lymph node metastasis in cN0 OSCC patients ( P <0.05). Multivariate Logistic regression analysis indicated that the growth pattern, degree of differentiation, depth of invasion, NLR, and the S/L ratio of lymph nodes were independent risk factors for cervical lymph node metastasis ( P <0.05). Conclusion : The growth pattern, degree of differentiation, depth of invasion, neutrophil/lymphocyte ratio, and the short/long axis diameter ratio of lymph nodes were the independent risk factors for pathological cervical lymph node metastasis in oral squamous cell carcinoma patients with cN0. If patients with the above risk factors receive nonstandard radical neck dissection or no dissection, it may be necessary for them to receive the corresponding regional postoperative radiotherapy.

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Squamous cell carcinoma of buccal mucosa: An analysis of prognostic factors

Cited by 44 publications

References 41 publications

Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China—a 10-year continuous single-center study

Analysis of primary oral and oropharyngeal squamous cell carcinoma in inhabitants of Beijing, China—a 10-year continuous single-center study

Cervical lymph node metastasis in squamous cell carcinoma of the buccal mucosa: a retrospective study on pattern of involvement and clinical analysis

Risk Factors Analysis of Pathologically Confirmed Cervical Lymph Nodes Metastasis in Oral Squamous Cell Carcinoma Patients with Clinically Negative Cervical Lymph Node: Results from a Cancer Center of Central China

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