Squamous-cell Carcinoma of the Anal Canal: Predictors of Treatment Outcome

Roohipour, Ramin; Patil, Sujata; Goodman, Karyn A.; Minsky, Bruce D.; Wong, W. Douglas; Guillem, José G.; Paty, Philip B.; Weiser, Martin R.; Neuman, Heather B.; Shia, Jinru; Schrag, Deborah; Temple, Larissa K.

doi:10.1007/s10350-008-9216-5

Cited by 7 publications

(8 citation statements)

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“…There are approximately 300 new cases each year in Australia . The incidence of anal carcinoma is increasing in Australia, similar to international figures . A combination of radiation therapy and chemotherapy has been the standard treatment since 1974, with greater than 70% colostomy‐free survival rates reported by Milano et al .…”

Section: Introductionmentioning

confidence: 66%

Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three‐dimensional conformal radiation therapy (3DCRT)

Sale

Moloney

Mathlum

2013

J of Medical Radiation Sci

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IntroductionPatients with anal canal carcinoma treated with standard conformal radiotherapy frequently experience severe acute and late toxicity reactions to the treatment area. Roohipour et al. (Dis Colon Rectum 2008; 51: 147–53) stated a patient's tolerance of chemoradiation to be an important prediction of treatment success. A new intensity modulated radiation therapy (IMRT) technique for anal carcinoma cases has been developed at the Andrew Love Cancer Centre aimed at reducing radiation to surrounding healthy tissue.MethodsA same-subject repeated measures design was used for this study, where five anal carcinoma cases at the Andrew Love Cancer Centre were selected. Conformal and IMRT plans were generated and dosimetric evaluations were performed. Each plan was prescribed a total of 54 Gray (Gy) over a course of 30 fractions to the primary site.ResultsThe IMRT plans resulted in improved dosimetry to the planning target volume (PTV) and reduction in radiation to the critical structures (bladder, external genitalia and femoral heads). Statistically there was no difference between the IMRT and conformal plans in the dose to the small and large bowel; however, the bowel IMRT dose–volume histogram (DVH) doses were consistently lower.ConclusionThe IMRT plans were superior to the conformal plans with improved dose conformity and reduced radiation to the surrounding healthy tissue. Anecdotally it was found that patients tolerated the IMRT treatment better than the three-dimensional (3D) conformal radiation therapy. This study describes and compares the planning techniques.

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Section: Introductionmentioning

confidence: 66%

Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three‐dimensional conformal radiation therapy (3DCRT)

Sale

Moloney

Mathlum

2013

J of Medical Radiation Sci

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“…Treatment breaks in general should be avoided whenever possible. However, this may be unavoidable because of treatment‐related toxicity like skin desquamation and diarrhea . IMRT has been shown to reduce toxicity and RT duration compared with 3DCRT; however, no differences in locoregional control, OS, or colostomy‐free survival were noted (Table ).…”

Section: Radiation Techniquesmentioning

confidence: 99%

Anal cancer: Current standards in care and recent changes in practice

Shridhar

Shibata

Chan

et al. 2015

CA A Cancer J Clinicians

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https://www.wileyhealthlearning.com/acs.aspx The management of squamous cell carcinomas of the anal canal has evolved from surgery as first‐line treatment to curative chemoradiation, with surgery reserved for salvage. Significant progress has been made in understanding how to most effectively deliver chemotherapy and reduce toxicity through advancements in radiation delivery. The purpose of this article is to review the multimodality approach to the diagnosis and management of anal cancer based on a review of the published data and in light of available guidelines. CA Cancer J Clin 2015;65: 139–162. © 2015 American Cancer Society.

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“…However, this therapy has toxic side effects such as nausea, diarrhea, anal ulcers, and other chronic effects. Eighteen percent of patients in one study experienced acute grade hematologic toxicity [57], and even short-term toxicity is always a concern, since this requires patients to take breaks from radiation treatments [58]. Some improvements in toxicity have resulted from the effective progression from the Nigro protocol, which used the addition of mytomycin C (MMC) to 5-fluorouracil (5-FU) and radiotherapy [50], to the less toxic combination of combined modality therapy with external beam radiation, cisplatin, and 5-FU [59].…”

Section: Treatment Of Scca In Immunocompetent and Immunocompromised Pmentioning

confidence: 99%

Current Understanding and Potential Immunotherapy for HIV‐Associated Squamous Cell Carcinoma of the Anus (SCCA)

Marín-Müller

Chen

et al. 2008

World j. surg.

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Squamous cell carcinoma of the anus (SCCA) is a rare disease in the average population, but is of increasing concern among immuncompromised individuals such as the HIV seropositive. Coinfection with human papillomavirus (HPV) in this population is common. HPV infection is difficult to clear with a compromised immune system, which results in a greater risk of tumor development and a more aggressive progression of the disease. The recent approval of a prophylactic HPV vaccine for cervical cancer has sparked an interest in a search for improved immunotherapeutic multimodality therapies to combat anogenital tumors associated with the virus. In this review, we discuss the known mechanisms of action of HIV-associated SCCA, examine the current treatments for the disease, and focus on the potential of an immunotherapeutic vaccine approach for both prophylactic and therapeutic application.

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Squamous-cell Carcinoma of the Anal Canal: Predictors of Treatment Outcome

Cited by 7 publications

References 0 publications

Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three‐dimensional conformal radiation therapy (3DCRT)

Carcinoma of the anal canal: Intensity modulated radiation therapy (IMRT) versus three‐dimensional conformal radiation therapy (3DCRT)

Anal cancer: Current standards in care and recent changes in practice

Current Understanding and Potential Immunotherapy for HIV‐Associated Squamous Cell Carcinoma of the Anus (SCCA)

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