Squamous-cell carcinoma of the colon responsive to combination chemotherapy

Abstract

Primary squamous-cell carcinoma of the colon is a rare malignancy of unknown cause and pathogenesis. Metastatic tumors to the colon should be ruled out in all cases before therapy. Early detection and surgery remain the main therapeutic options, but as presented in our case, response to chemotherapy in advanced disease is encouraging.

Basaloid Squamous Cell Carcinoma of the Rectum: A Rare Entity

“…In mixed adenosquamous variety, Cerezo and others suggested that all such lesions be carefully evaluated by means of immunoperoxidase stains and/or electron microscopy in order to identify squamous features [20,21]. Symptoms, investigations, and assessment of patients with the divergent histologic subtypes of squamous cancer of the colon and rectum, including basaloid tumors, are similar to those of colon adenocarcinoma, as is evident in our case [5,22]. However, the prognosis of patients with colorectal SCC is difficult to establish due to the rarity of these tumors.…”

A population-based study of colorectal cancer histology in the United States, 1998–2001

“…18 A populationbased study of anal epidermoid carcinomas did not reveal a sex-specific difference. 19 However, a study using data from the Utah cancer registry found a greater proportion of squamous cell cancers (listed as a subtype of epidermoid cancers in this study) in females.…”

Squamous cell carcinoma of the cecum developing in a patient with long-standing ulcerative colitis and a coexistent carcinoid tumor in the appendix: A case report

“…The pathogenesis of these tumors is poorly understood but may involve squamous de-differentiation of a pre-existing adenocarcinoma or squamous metaplasia progressing to dysplasia and carcinoma as a result of a chronic inflammatory stimulus (1)(2)(3)(4)(5). In the present case, the presence of squamous metaplasia in the adjacent mucosa suggests the latter.…”