Squamous cell carcinomas of the lower limbs in African American women

Woolery‐Lloyd, Heather; Elsaie, Mohamed L.; Avashia, Nidhi

doi:10.1016/j.jaad.2009.11.019

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…In contrast, in nonalbino blacks no multifocal or truncal lesion was recorded and SCC, which were predominant of the keratinocyte carcinomas, occurred mostly in the anogenital region followed by lower limbs. Review of pattern of occurrence in African Americans, in keeping with our present findings, highlights SCC as the most common skin cancer in blacks, with lower limbs and anogenital regions as the most frequently involved body sites 30,32,33 . The preferred involvement of sun‐exposed body sites in African albinos and occurrence of multiple tumors correspond to the reported pattern of keratinocyte carcinomas in Caucasians 21,34 .…”

Section: Discussionsupporting

confidence: 86%

“…Review of pattern of occurrence in African Americans, in keeping with our present findings, highlights SCC as the most common skin cancer in blacks, with lower limbs and anogenital regions as the most frequently involved body sites. 30,32,33 The preferred involvement of sun-exposed body sites in African albinos and occurrence of multiple tumors correspond to the reported pattern of keratinocyte carcinomas in Caucasians. 21,34 In one study, 31 38% of white patients had multiple tumors ranging from 2 to 52, some of which were mixed SCC and BCC.…”

Section: Discussionsupporting

confidence: 76%

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Primary cutaneous malignancies in nonalbino and albino Africans

Okafor

Onyishi

2020

Int J Dermatology

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Background The pigmented skin of black Africans has been credited with reduction in risk of skin cancer. African albinos have inherited defects in skin melanin deposition, which predisposes them to ultraviolet radiation‐induced cutaneous carcinogenesis. We compared the manifestation of skin cancers between albino and nonalbino Africans aiming to describe the effect of pigmentation or lack of it on the epidemiological characteristics of skin cancer in Africans. Materials and methods Cutaneous malignancies seen in our institution over a 19‐year period were analyzed using SPSS statistical software. Results were presented in tables of frequencies. Continuous variables were presented as mean with standard deviation and compared with independent sample t‐test and ANOVA. Alpha level of <0.05 was considered significant. Result There were 86 albinos and 364 nonalbinos in the study. Mean age (SD) at presentation for albinos was 41 (14) years and for nonalbinos 52 (17) years. Albinos had most tumors in the head and neck region and upper extremities. For nonalbinos, lower extremities followed by anogenital region were the most common body site of cutaneous malignancy. Squamous cell carcinoma was the most common type of skin cancer in the albino and nonalbino patients. No case of malignant melanoma was diagnosed in the albino group. Conclusion Albino skin cancer patients were much younger than nonalbinos. Albinos and nonalbinos differ in body site distribution of skin cancers. Distribution of keratinocyte carcinomas in albinos parallels the reported findings in Caucasians. Albinos may have some level of protection from cutaneous melanoma in spite of hypomelanized skin.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 76%

Primary cutaneous malignancies in nonalbino and albino Africans

Okafor

Onyishi

2020

Int J Dermatology

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“…Compared to Caucasians, SCC in the African American population is uncommon, with females being affected more than males, and lower extremity being the most common site (12,13). The incidence of SCC in chronic ulcers has been reported to be approximately 1% in a small retrospective study (14).…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer

Saeed

George

Lajara

et al. 2017

AACE Clinical Case Reports

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Objective: To report a case of hypercalcemic crisis in an African American male who presented with a nonhealing ulcer which was later found to be squamous cell carcinoma.Methods: All relevant data, radiologic imaging, and pathology reports were reviewed in detail. An in-depth literature review for humoral hypercalcemia of malignancy and cutaneous squamous cell carcinoma was performed using MEDLINE.Results: A 58-year-old man with a history of chronic lymphedema presented with fever and a nonhealing left foot ulcer. Initial studies revealed acute kidney injury, anemia, and non-parathyroid hormone (PTH)-mediated hypercalcemic crisis (calcium, 17.7 mg/dL). A thorough work-up ruled out bone metastasis and confirmed increased PTH-related peptide, which is the hallmark of humoral hypercalcemia of malignancy (HHM). Hypercalcemia was initially managed with intravenous fluid hydration, bisphosphonates, and calcitonin. The patient had surgical resection of the left leg, and pathology revealed cutaneous squamous cell carcinoma. Hypercalcemia resolved completely after surgical resection of the tumor.

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“…SCC (or epidermoid carcinoma) most commonly occurs on sun‐exposed areas in white people whereas it is frequently located on sun‐protected sites (i.e. lower limbs or anogenital area) in Black people . In fact, additional factors other than UV radiation have been identified as major aetiologic triggers in the development of SCC in the Black population: that is, chronic scarring caused by chemicals, thermal burns or skin ulcers as well as inflammatory processes such as lupus erythematosus and hidradenitis suppurativa.…”

Section: Introductionmentioning

confidence: 99%

“…lower limbs or anogenital area) in Black people. [1][2][3][4][5][6][7][8][9][10][12][13][14][15] In fact, additional factors other than UV radiation have been identified as major aetiologic triggers in the development of SCC in the Black population [1][2][3][4][5][6]8,9,12 : that is, chronic scarring caused by chemicals, thermal burns or skin ulcers as well as inflammatory processes such as lupus erythematosus and hidradenitis suppurativa. Moreover, high-risk human papillomaviruses (HRHPV) have now been identified due to their implication in the development of anogenital SCC although specific studies focusing on POC have, to our knowledge, not yet been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma in the Afro‐Caribbean community: an 11‐year retrospective study

Cordel

Bonnecarrere

Tressières³

2017

Acad Dermatol Venereol

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Squamous cell carcinoma is the most frequent skin cancer in Black people. Its incidence is not known in the Afro-Caribbean population. In Guadeloupe, the largest island of the Lesser Antilles, the annual age-adjusted incidence of SCC was estimated to be 15.0 per 100 000 residents, 95% CI:[13.8; 16.2]. In the Guadeloupean Afro-Caribbean community, SCC seems to more frequently occur in the anogenital area, due to HPV infection. These results support to include a routine genital urinary examination in the skin cancer screening of people of Afro-Caribbean descent.

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Squamous cell carcinomas of the lower limbs in African American women

Cited by 6 publications

References 11 publications

Primary cutaneous malignancies in nonalbino and albino Africans

Primary cutaneous malignancies in nonalbino and albino Africans

A Rare Case of Hypercalcemic Crisis Secondary to a Squamous Cell Carcinoma Arising from a Nonhealing Ulcer

Squamous cell carcinoma in the Afro‐Caribbean community: an 11‐year retrospective study

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