Squamous Islands in Eccrine Neoplasms

Kohda, Mamoru; Manabe, Toshiaki; Ueki, Hiroaki

doi:10.1097/00000372-199008000-00003

Cited by 19 publications

(18 citation statements)

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“…1,3,4,6 The morphological features of these tumors, including foci of ductal differentiation present within atypical squamous islands, are consistent with a tumor with overlapping ductal and squamoid features. However, in our case, there was also evidence of follicular differentiation, including areas of infundibular-type keratinization with scattered horn cysts showing dense laminated keratin, and clear cells suggestive of tricholemmal differentiation.…”

Section: Discussionsupporting

confidence: 53%

“…In addition, the other cases reported to date have not appeared to show an aggressive course. 3,4,6 This is in contrast to cases described as traditional eccrine carcinoma, which have been reported to show metastasis FIGURE 5. A, A cytokeratin 17 stain was strongly positive within many of the tumor cells, especially within the larger and more squamoid cells.…”

Section: Discussionmentioning

confidence: 75%

“…1 Whether this rare tumor represents an unusual squamous cell carcinoma (SCC) arising from eccrine ducts or an eccrine carcinoma with extensive squamoid differentiation has been unclear and is a matter of debate in the literature. [1][2][3][4][5][6][7] However, these tumors show significant overlap with microcystic adnexal carcinoma (MAC), a low-grade adnexal tumor that shows follicular and ductal differentiation, and may occasionally show squamous metaplasia. 5,8 MAC has been categorized as a folliculosebaceous-apocrine unit (FSAU) neoplasm by multiple authors.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11] Therefore, it is possible that SEDC may also be a tumor with FSAU differentiation rather than eccrine differentiation. Given the very few cases described to date, 1,3,4,6 it is difficult to assess the biological potential of these tumors. However, we report a case which appears to be a relatively indolent tumor, as it was reportedly present for at least 3 years before biopsy, has not shown recurrence or metastasis, and the histological and immunohistochemical findings favored a low-grade lesion.…”

Section: Introductionmentioning

confidence: 99%

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“Squamoid Eccrine Ductal Carcinoma”: An Unusual Low-Grade Case With Follicular Differentiation. Are These Tumors Squamoid Variants of Microcystic Adnexal Carcinoma?

Kavand¹,

Cassarino²

2009

The American Journal of Dermatopathology

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Squamoid eccrine ductal carcinoma is a rare primary cutaneous tumor exhibiting both squamous and adnexal ductal differentiation. The cell of origin of these tumors is unknown, and they have been classified both as variants of cutaneous squamous cell carcinoma and as a type of eccrine carcinoma. Only 6 of these tumors have been reported in the literature to date. We report an additional case of a slow-growing tumor, occurring on the great toe of a 61-year-old woman, which was unusual as it showed follicular differentiation in addition to squamoid and ductal areas. The lesional cells were positive for cytokeratins 7 and 17, carcinoembryonic antigen (which highlighted the ductal structures), and p63 (favoring a primary cutaneous tumor) and showed low levels of staining with Ki-67 and p53, consistent with a low-grade tumor. We postulate that these tumors may be closely related to microcystic adnexal carcinoma and similarly show differentiation along both follicular and ductal lines, likely indicating folliculosebaceous-apocrine, rather than eccrine, origin or differentiation.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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“Squamoid Eccrine Ductal Carcinoma”: An Unusual Low-Grade Case With Follicular Differentiation. Are These Tumors Squamoid Variants of Microcystic Adnexal Carcinoma?

Kavand¹,

Cassarino²

2009

The American Journal of Dermatopathology

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“…However, given the dual potential of the acrosyringium, the tendency to squamous differentiation in poral neoplasms is less commonly encountered than one would expect. This observation is based on the paucity of reported cases of EPC showing prominent squamous differentiation as well as reference to the absence of squamous differentiation in several large reviews on EPC 2 – 7…”

mentioning

confidence: 99%

The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases

2007

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The findings suggest a possible role for ultraviolet radiation and chronic immunosuppression in the induction of malignant squamous differentiation in a subset of EPCs. Further reports on this histological variant of EPC are required to determine whether a pathogenetic link does indeed exist or whether these tumours simply represent a unique variant of squamous cell carcinoma with divergent acrosyringial differentiation.

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Porocarcinoma of the heel: A case report with unusual histologic features

D'Amato¹,

Patterson

Guccion

et al. 1996

Cancer

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BACKGROUND.Eccrine porocarcinoma is an uncommon neoplasm of the intraepidermal sweat gland duct. METHODS. A case of porocarcinoma of the right heel in a male age 51 years is described with a review of pertinent literature. The surgically excised neoplasm was evaluated by routine histology and transmission electron microscopy. RESULTS. The porocarcinoma showed extensive nuclear pleomorphisms with frequent, multinucleated tumor giant cells, focal epidermotrophic spread within the epidermis, a peripheral, eccrine syringofibroadenoma-like growth pattern, and an origin in a contiguous eccrine poroma. Ultrastructurally, the squarnous tumor cells contained rare intracytoplasrnic lumens. CONCLUSIONS. The extensive nuclear pleomorphism with frequent tumor giant cells was an unusual feature of the porocarcinoma. Its epidermotrophic spread within the epidermis and its origin in a contiguous eccrine poronia supported the diagnosis of porocarcinoma. The eccrine syringofibroadenoma-like growth pattern in the periphery of the tumor was a unique and previously undescribed feature of the porocarcinoma. The presence of intracytoplasmic lumens in squamous tumor cells mimicked embryonic development of the intraepidermal sweat gland duct.

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Squamous Islands in Eccrine Neoplasms

Cited by 19 publications

References 0 publications

“Squamoid Eccrine Ductal Carcinoma”: An Unusual Low-Grade Case With Follicular Differentiation. Are These Tumors Squamoid Variants of Microcystic Adnexal Carcinoma?

“Squamoid Eccrine Ductal Carcinoma”: An Unusual Low-Grade Case With Follicular Differentiation. Are These Tumors Squamoid Variants of Microcystic Adnexal Carcinoma?

The squamous variant of eccrine porocarcinoma: a clinicopathological study of 21 cases

Porocarcinoma of the heel: A case report with unusual histologic features

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