Squamous Neoplasia in the Esophagus

Savant, Deepika; Zhang, Qingzhao; Yang, Zhaohai

doi:10.5858/arpa.2020-0058-ra

Cited by 13 publications

(9 citation statements)

References 51 publications

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“…Vienna classification 1 (Figure 2 and 3). papillary leukoplakia), their therapeutic alternatives are: resection with biopsy, cauterization, radiofrequency ablation, mucosectomy for large lesions and esophagectomy if the presentation is extreme and does not respond to more conservative therapy [6]. In this case, the lesion was single and small, which corresponds to what is described in the literature.…”

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confidence: 60%

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Esophageal Squamous Cell Papilloma. Case Report

Simbaña¹,

Mora

Dávila³

et al. 2022

Hepatol Gastroenterol

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Background. Esophageal squamous cell papillomas are rare epithelial lesions with malignant potential, diagnosed by upper gastrointestinal endoscopy. Their prevalence is from 0.01% to 0.43%. Objective. Description of rare esophageal squamous papilloma diagnosed during upper gastrointestinal endoscopy. Material and methods. A 38-year-old asymptomatic female patient underwent an upper gastrointestinal endoscopy. A growth described as an "esophageal polyp" was detected. The biopsy was performed and specimens were sent for histopathological study. Results. The final diagnosis of esophageal squamous papilloma was made due to histopathological study. Because of the malignant potential of these lesions, once diagnosed, early treatment is essential to prevent progression to esophageal carcinoma. Conclusions. Esophageal squamous papillomas are increasing in prevalence and have been shown to be potentially malignant. This argues the relevance of the problem and the need for widespread immunizations to control human papillomavirus infection.

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Section: Figures 1-3 Show the Results Of Macroscopic And Microscopic ...supporting

confidence: 60%

“…Human papillomavirus infection has been related to the development of squamous cell carcinomas in the anogenital, oral, and laryngeal regions; the prevalence of dysplastic lesions of the hypopharynx ranges between 13% and 24% [6].…”

Section: Introductionmentioning

confidence: 99%

Esophageal Squamous Cell Papilloma. Case Report

Simbaña¹,

Mora

Dávila³

et al. 2022

Hepatol Gastroenterol

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“…Histologically, squamous papillomas consist of a papillary proliferation of non-dysplastic squamous epithelium with fibrovascular cores of lamina propia and koilocytes can be seen; progression to dysplasia or carcinoma is extremely rare. 8 Infection with HPV has been found in apparently normal oesophageal mucosa, squamous papillomas and squamous cell carcinomas of the oesophagus. It has been suggested that HPV has a role in the pathogenesis of squamous cell carcinoma of the oesophagus.…”

Section: Discussionmentioning

confidence: 99%

Oesophageal squamous papilloma in paediatric population: a single-centre case series

Almeida

Vásconez-Muñoz

Vásconez-Montalvo

et al. 2023

bmjpo

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PurposeOesophageal squamous papilloma (OSP) is a rare epithelial lesion with an unclear aetiology, found incidentally in upper gastrointestinal endoscopy (UGE). We evaluate the epidemiology, general features and endoscopic and histological characteristics of OSP in children in a single centre.MethodsWe conducted a retrospective search of 3568 medical records of children under 18 years old who underwent UGE between 2004 and 2022, at Hospital Metropolitano de Quito, Ecuador. We described the general features of 15 patients diagnosed with OSP. Histopathology reports were analysed, including a chromogenic in situ hybridisation (CISH) for human papillomavirus (HPV) 6/11.ResultsOSP was diagnosed in 15 patients between 10 and 16 years of age, with an estimated prevalence of 0.4%. The gender ratio male to female was 1:1.1. Most patients (n=14) underwent UGE due to abdominal pain. Lesions were found predominantly in the upper and lower part of the oesophagus; 12 patients had isolated lesions, and none of the lesions tested positive for HPV on CISH 6/11 analysis. Additionally,Helicobacter pyloriand eosinophilic oesophagitis (EoE) were diagnosed in one patient each.ConclusionOur study describes the clinical features of paediatric OSP in a single centre. The prevalence was similar to that in the adult population but higher than in other paediatric populations, and none of our patients had HPV.

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“…Therefore, the authors collected the histologically confirmed images from consecutive patients with any type of esophageal cancer or precursor lesions found during upper gastrointestinal endoscopy to reflect a real situation. Various prevalence values of squamous dysplasia ranging from 3% to 38% have been reported in the literature [ 17 , 18 ]. , However, a small distribution (1.3%) of esophageal dysplasia was noted in the training dataset in our study.…”

Section: Discussionmentioning

confidence: 99%

Deep-Learning for the Diagnosis of Esophageal Cancers and Precursor Lesions in Endoscopic Images: A Model Establishment and Nationwide Multicenter Performance Verification Study

Gong

Bang

Jung

et al. 2022

JPM

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Background: Suspicion of lesions and prediction of the histology of esophageal cancers or premalignant lesions in endoscopic images are not yet accurate. The local feature selection and optimization functions of the model enabled an accurate analysis of images in deep learning. Objectives: To establish a deep-learning model to diagnose esophageal cancers, precursor lesions, and non-neoplasms using endoscopic images. Additionally, a nationwide prospective multicenter performance verification was conducted to confirm the possibility of real-clinic application. Methods: A total of 5162 white-light endoscopic images were used for the training and internal test of the model classifying esophageal cancers, dysplasias, and non-neoplasms. A no-code deep-learning tool was used for the establishment of the deep-learning model. Prospective multicenter external tests using 836 novel images from five hospitals were conducted. The primary performance metric was the external-test accuracy. An attention map was generated and analyzed to gain the explainability. Results: The established model reached 95.6% (95% confidence interval: 94.2–97.0%) internal-test accuracy (precision: 78.0%, recall: 93.9%, F1 score: 85.2%). Regarding the external tests, the accuracy ranged from 90.0% to 95.8% (overall accuracy: 93.9%). There was no statistical difference in the number of correctly identified the region of interest for the external tests between the expert endoscopist and the established model using attention map analysis (P = 0.11). In terms of the dysplasia subgroup, the number of correctly identified regions of interest was higher in the deep-learning model than in the endoscopist group, although statistically insignificant (P = 0.48). Conclusions: We established a deep-learning model that accurately classifies esophageal cancers, precursor lesions, and non-neoplasms. This model confirmed the potential for generalizability through multicenter external tests and explainability through the attention map analysis.

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Squamous Neoplasia in the Esophagus

Cited by 13 publications

References 51 publications

Esophageal Squamous Cell Papilloma. Case Report

Esophageal Squamous Cell Papilloma. Case Report

Oesophageal squamous papilloma in paediatric population: a single-centre case series

Deep-Learning for the Diagnosis of Esophageal Cancers and Precursor Lesions in Endoscopic Images: A Model Establishment and Nationwide Multicenter Performance Verification Study

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