Squamous papillary neoplasia of the adult upper aerodigestive tract

Crissman, John D.; Kessis, Ted; Shah, Keerti V.; Fu, Yao; Stoler, Mark H.; Zarbo, Richard J.; Weiss, Mark A.

doi:10.1016/s0046-8177(88)80231-4

Cited by 70 publications

(45 citation statements)

References 32 publications

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“…However, the findings may help to illustrate better the extremely well differentiated nature of papillary SCCA in comparison to other forms of invasive oral SCCA, especially the potential retention of cell-adhesion properties in this tumor as demonstrated by the strong expression of CD44. This may support to the view that papillary SCCA is a distinct very well differentiated variant of SCCA with a much better prognosis as observed in many cases [32,33].…”

Section: Resultssupporting

confidence: 82%

CD44 Expression in Intraoral Salivary Ductal Papillomas and Oral Papillary Squamous Cell Carcinoma

Fitzpatrick

Montague

Cohen

et al. 2012

Head and Neck Pathol

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CD44 is a transmembrane adhesion molecule which has been previously shown to be useful in the differentiation of benign papillary lesions from invasive carcinoma in several different areas including sinonasal mucosa and breast tissue. CD44 expression has previously been shown to be lost in invasive carcinoma and retained in benign papillary lesions in both of the above locations. In addition, studies have evaluated oral mucosal lesions for CD44 expression and found a loss with invasive squamous cell carcinoma when compared to normal epithelium, hyperplasia, and squamous papillomas, which stained particularly strongly. To the best of our knowledge, no study has evaluated CD44 expression when comparing salivary ductal papillomas in comparison to oral papillary SCCA. In this study 18 cases of intraductal papilloma were compared to 19 cases of oral papillary SCCA. Within the ductal papilloma group, all cases stained either absent (6 %), weakly (33 %), or moderately (61 %) with 76 % expressing the stain diffusely and 24 % focally. In comparison, the papillary squamous cell carcinoma cases expressed the CD44 moderately (26 %) or strongly (74 %) with 100 % showing diffuse staining. Thus, the CD44 expression was contrary to expectation based on previous studies, which we hypothesize is due to the extremely well differentiated nature of papillary SCCA which expressed CD44 staining compatible with levels previously reported with oral squamous papillomas than invasive carcinoma.

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Section: Resultssupporting

confidence: 82%

CD44 Expression in Intraoral Salivary Ductal Papillomas and Oral Papillary Squamous Cell Carcinoma

Fitzpatrick

Montague

Cohen

et al. 2012

Head and Neck Pathol

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“…However, some authors speculate that this condition might actually be a reaction of the tissue to injury rather than a true neoplasia (Harries et al, 1995). In recent years, a clear connection has been established between human papillomavirus (HPV) and the development of squamous papilloma (Crissman et al, 1988;Briskin and Kerner, 1994). The primary means of HPV transmission to children is the ingestion of viral particles of infected cells from the birth canal, whereas in adults HPV is mainly transmitted through sexual contact.…”

Section: Discussionmentioning

confidence: 99%

Squamous Papilloma: Case Report and Review of Literature

2010

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Squamous papillomas are common lesions of the oral mucosa with a predilection for the mucosa of the hard and soft palate. As an oral lesion, it raises concern because of its clinical appearance, which may mimic exophytic carcinoma, verrucous carcinoma or condyloma acuminatum. Its pathogenesis is related to human papilloma virus but there is controversy regarding its viral origin. We present a case of squamous papilloma presenting as oral lesion along with a review of the literature.

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“…Papillary (exophytic) SCC represents an uncommon but distinct subtype of head and neck SCC (43)(44)(45). The demographics for this subtype of SCC are similar to those of conventional SCC, with the tendency to affect men more than women and to occur in adults, with a mean age in the 7th decade of life.…”

Section: Papillary (Exophytic) Sccmentioning

confidence: 99%

“…The demographics for this subtype of SCC are similar to those of conventional SCC, with the tendency to affect men more than women and to occur in adults, with a mean age in the 7th decade of life. Papillary SCCs predilect to the larynx, oral cavity, oro-and hypopharynx, and sinonasal tract (43)(44)(45). The larynx is the most common site of occurrence.…”

Section: Papillary (Exophytic) Sccmentioning

confidence: 99%