Square wave adsorptive stripping voltammetric determination of anticancer drug nilutamide in biological fluids using cationic surfactant cetyltrimethylammonium bromide

Abstract

A sensitive square wave adsorptive stripping voltammetric method was described for the determination of anticancer drug nilutamide (NLM) in biological fluids based on the enhancement effect of the cationic surfactant: cetyltrimethylammonium bromide (CTAB). With pH 6.0 Britton-Robinson (BR) buffer as the supporting electrolyte and in the presence of 1.45 Â 10 À4 mol L À1 CTAB, NLM yields a well-defined and sensitive reduction peak at the ZnO nanoparticle modified carbon paste electrode (ZnONPs/CPE).Various chemical and instrumental parameters affecting the monitored electroanalytical response were investigated and optimized for NLM determination. The electrochemical parameters such as the surface concentration (G), electron transfer coefficient (a) and standard rate constant (k s ) of NLM at the modified electrode were calculated. The achieved limits of detection and quantification were 3.21 Â 10 À9 mol L À1 and 1.07 Â 10 À8 mol L À1 by square wave adsorptive stripping voltammetry (SWAdSV), respectively. The proposed method was successfully applied for the detection of NLM in blood and urine samples with good accuracy and precision.

Voltammetric determination of the anti-cancer drug nilutamide using a screen-printed carbon electrode modified with a composite prepared from β-cyclodextrin, gold nanoparticles and graphene oxide

“…Here, GO and β-CD provide excellent support to the distribution of AuNP and increases the stability of AuNP in agglomerate. This composite have resulted in good electrochemical behavior for the determination of nilutamide and has achieved a superior limit of detection in comparison with the previously reported work [6].…”

“…The analytical performance of the nilutamide reduction on the β- CD-AuNP/GO/SPCE was compared with other previously reported analytical methods, as shown in Table 1. As stated earlier, only one electrochemical method (SWV) has been developed for nilutamide determination [6]. Comparatively, the demonstrated disposable β-CD-AuNP/GO/SPCE exhibits good analytical performance in comparison with other reported nilutamide detection methods and achieved a very low LOD.…”

“…Hence, the critical determination of nilutamide in biological fluids is important. So far, only limited methods of analysis have been developed and reported for the detection of nilutamide, such as spectrophotometry, square wave voltammetry (SWV) and micellar electrokinetic chromatography [4][5][6]. In this case, the SWV is an electrochemical method which is faster, more selective and more sensitive for the determination of nilutamide than other techniques.…”

“…Nilutamide has been examined in very few reports, despite its various adverse pharmacological effects [4][5][6]. In recent years, various chemically and electrochemically modified electrodes have been reported for the determination of biomolecules and drugs.…”

Application of a Nanosensor Based on MWCNT‐Sodium Dodecyl Sulphate Modified Electrode for the Analysis of a Novel Drug, Alpha‐Hydrazinonitroalkene in Human Blood Serum

“…There are four types of surfactants namely, anionic, cationic, non‐ionic and zwitter ionic. Surfactants are capable of enriching solution electrode interface with electrical properties, get adsorbed at the electrode surface and solubilise in the solution hence they are employed in both, modifications of the sensors as well as in solution to improve electrode/solution interface properties . Sodium dodecyl sulphate (SDS) is an anionic surfactant with negatively charged hydrophilic sulphate group attached to 12 carbon atoms forming a hydrophobic tail.…”