Squeeze-film properties of synovial fluid and hyaluronate-based viscosupplements

Torzilli, Peter A.; Hubbard, Robert B.; Pecorari, Isabella L.

doi:10.1007/s10237-021-01485-x

Cited by 2 publications

(2 citation statements)

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“…Based on this data, the IA injection volumes for this study were selected as 2 or 4 mL to maintain clinical relevancy. The rheological properties of HA solutions are HA concentration and molecular weight dependent, their viscosity increasing with both factors 39 . For average to high‐molecular‐weight HA products labeled for use in veterinary medicine, 10 mg/mL is the most common concentration.…”

Section: Discussionmentioning

confidence: 99%

“…The rheological properties of HA solutions are HA concentration and molecular weight dependent, their viscosity increasing with both factors. 39 For average to high-molecular-weight HA products labeled for use in veterinary medicine, 10 mg/mL is the most common concentration. Most manufacturers do not report viscosities or molecular weights except for Hyalovet (500-730 kDa) (Boehringer Ingelheim Animal Health USA Inc., Ridgefield, Connecticut).…”

Section: ) 2ml 4mlmentioning

confidence: 99%

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Impact of arthroscopy on post‐procedure intra‐articular elbow injections: A cadaveric study

Blumhagen,

Spector,

Fischetti

2024

Veterinary Surgery

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ObjectiveTo determine the influence of arthroscopy and injection volume on post‐procedure intra‐articular (IA) injection extravasation.Study designEx vivo prospective study.Sample populationA total of 40 paired canine cadaver forelimbs.MethodsAfter radiographs and computed tomography (CT) scans with three‐dimensional (3D) digital bone model reconstructions, elbows were randomly assigned to the arthroscopy or control group and randomly assigned to receive an IA injection of 2 or 4 mL of contrast. Elbow arthroscopy was performed on assigned specimens, followed by IA injections of contrast in all elbows, and imaging was repeated. 3D digital model volumes were compared. Images were interpreted and scored for extravasation by a radiologist unaware of treatment and volume assignments.ResultsBased on CT images and regardless of treatment group, IA injections of 4 mL resulted in a mean extravasation score of 2.25 (SD 0.97) versus 1.55 (SD 1.05) (p = .02) for 2 mL IA injections. The change in 3D model volumes after IA injections was a mean of 13.2 cm3 (SD 5.85) after 4 mL injections, compared to 6.97 cm3 (SD 6.28) (p = .003) after 2 mL injections. On radiographic evaluation, but not CT, the mean extravasation scores were 2.45 (SD 1.15) for the arthroscopy group and 1.25 (SD 0.79) for the control group (p < .001).ConclusionA larger volume of IA injection resulted in higher CT extravasation scores and larger 3D volumes regardless of arthroscopic treatment.Clinical significanceIA injections performed immediately after arthroscopy resulted in 50% or less extravasation, especially with a smaller IA injection volume.

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Section: Discussionmentioning

confidence: 99%

Section: ) 2ml 4mlmentioning

confidence: 99%