SR-BI et métabolisme du cholestérol.

Combettes-Souverain, M.; Milliat, Fabien; Sérougne, Colette; Férézou, Jacqueline; Lutton, C.

doi:10.4267/10608/1252

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…Even though Schwab et al [13] considered the differences they observed in serum and LDL-cholesterol of minor clinical significance in humans, this suggestion was not based on histological data analysis. In our case, results from a study published by our team [48] indicated that even with higher levels of atheroprotective HDL [44], the betaine-fed pigs presented larger (P,0.01) atherosclerotic lesion areas in the left coronary arteries (higher artery total thickness, higher tunica adventitia and media thickness, and more animals with type II lesions) than those in the control group. This suggests that betaine presents disadvantages when used as an Hcy-lowering agent, even more if we consider that it is not firmly established that Hcy lowering indeed reduces risk of CVD [2].…”

Section: Discussionmentioning

confidence: 56%

“…In the fasted period, this could reflect a decrease in tissue and hepatic removal of these particles. Betaine decreased Hcy in plasma but could also modify cysteine metabolism, and particularly membrane proteins which are rich in this amino acid, such as for example scavenger receptor class B type I (SR-BI) which is involved in the uptake of HDL particles [44]. To our knowledge, there are no available data relating plasma HDL-cholesterol level and betaine supplementation on this animal model but recently, Hamelet et al [45] found that hyperhomocysteinemia in cystathionine beta synthase (CBS)-deficient mice significantly increased the hepatic expression of the SR-BI.…”

Section: Discussionmentioning

confidence: 99%

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Betaine supplementation affects the cholesterol but not the lipid profile of pigs

Martins

Neves

Freitas

et al. 2010

Euro J Lipid Sci & Tech

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This study was undertaken to investigate the effects of long term betaine intake on the cholesterol and lipid profile of Alentejano (AL) pigs. At ,36 kg body weight (BW), castrated male and female pigs fed a commercial (C) diet, were divided into two groups: i) Group C, consuming the C diet; and ii) Group CB, consuming the C diet supplemented with 1 g/kg betaine. Pigs were slaughtered at ,100 kg BW. Fasting plasma concentrations of protein, urea, glucose, TAG, phospholipids, homocysteine, total and LDL-and HDL-cholesterol were determined. Liver TAG, phospholipids, and total and free cholesterol were analyzed, as well as total lipids, cholesterol contents, and fatty acid (FA) composition of M. semimembranosus and dorsal subcutaneous fat. Betaine supplemented pigs presented significantly higher plasma concentrations of TAG, phospholipids, cholesterol, and lipoprotein cholesterol. The dorsal subcutaneous fat cholesterol concentration was also significantly higher in CB than in C pigs. No differences were detected in the most abundant FA profile (including the unsaturated to saturated FA ratio) of muscle and subcutaneous fat tissues among treatments. These data suggest that betaine induces dyslipidemia, and increases cholesterol concentration in dorsal subcutaneous fat, without affecting the FA profile of M. semimembranosus and dorsal subcutaneous fat. Eur. J. Lipid Sci. Technol. 2010, 112, 295-303 295 Practical applicationsBetaine has been used as a carcass modifier on pigs and also as a homocysteine-lowering agent, the high plasma concentrations of which are considered a risk factor for pathologies such as coronary heart disease (CHD) and atherosclerosis. This work showed no effect of long term betaine consumption (2 g/ d) on body fat deposition and total lipids and FA profile of M. semimembranosus and dorsal subcutaneous fat of pigs. It also showed that betaine consumption induces dyslipidemia, namely by increasing cholesterolemia and the dorsal subcutaneous fat cholesterol concentration, without affecting the FA profile of muscle and fat tissues. These observations indicate that the use of betaine: i) did not alter muscle total lipids and FA profile of the tissues analysed, which would be of concern to consumers' health and to pig producers using betaine as a carcass modifier; but ii) must be further studied since it induces hypercholesterolemia, a CHD risk factor.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Betaine supplementation affects the cholesterol but not the lipid profile of pigs

Martins

Neves

Freitas

et al. 2010

Euro J Lipid Sci & Tech

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show abstract

“…Furthermore, the scavenger receptor SR-BI, an HDL receptor [1], plays an important role in plasma cholesterol regulation, specially in rodents [5]. However, only one recent study [39] has reported that saturated fatty acids modify the expression of SR-BI compared to polyunsaturated fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of Scavenger receptor BI without affecting bile acid biosynthesis in hamsters

Loison

Mendy²,

Sérougne

et al. 2002

Reprod. Nutr. Dev.

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-The purpose of this study was to analyze the effects of increasing amounts of dietary myristic acid (0.03 to 4.2% of the total dietary energy) on the plasma and hepatic cholesterol metabolism. Six groups of hamsters received semi-purified diets containing 0.05% cholesterol and 12.5% lipids and differing only by the nature of the triglycerides (Safflower oil, lard, lard/coconut oil (1:1), milk fat, milk fat/coconut oil (1:1), coconut oil) for 3 weeks. A positive regression between the plasma cholesterol level and the dietary myristic acid level was observed (r = 0.60, P < 0.0001). However, it is noteworthy that the increase in plasma total cholesterol only reflects an increase in the level of HDL-cholesterol. In parallel, the mass SR-BI decreased linearly with the increased level of myristic acid in the diet, whereas the LDL-R did not change. This study shows that increasing amounts of myristic acid (0.03 to 4.2%) do not alter the cholesterol or bile acid metabolism and increase only the HDL-C. myristic acid / cholesterol / LDL receptor / SR-B1 / hamsterRésumé -Des doses croissantes d'acide myristique dans l'alimentation modifient la concentration plasmatique du cholestérol et la quantité de SR-BI, sans affecter la biosynthèse des acides biliaires chez le hamster. Le but de cette étude était d'analyser les effets de doses croissantes d'acide myristique (0,03 à 4,2 % de l'apport énergétique total) sur le métabolisme plasmatique et hépatique du cholestérol. Six groupes de hamsters ont reçu des régimes semi-synthétiques contenant 0,05 % de cholestérol et 12,5 % de lipides (carthame, saindoux, saindoux/huile de coco (1:1),

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Los fibratos modifican la expresión hepática de colesterol 7-α-hidroxilasa, MDR3 y ABCG5 en pacientes con colelitiasis

Roglans

Novell²,

Zambón³

et al. 2004

Clínica e Investigación en Arteriosclerosis

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SR-BI et métabolisme du cholestérol.

Cited by 5 publications

References 37 publications

Betaine supplementation affects the cholesterol but not the lipid profile of pigs

Betaine supplementation affects the cholesterol but not the lipid profile of pigs

Increasing amounts of dietary myristic acid modify the plasma cholesterol level and hepatic mass of Scavenger receptor BI without affecting bile acid biosynthesis in hamsters

Los fibratos modifican la expresión hepática de colesterol 7-α-hidroxilasa, MDR3 y ABCG5 en pacientes con colelitiasis

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