SSRIs and cognitive performance in a working sample

Abstract

The findings lend support to the SSRIs comparative safety, even among workers, particularly as the symptoms of the underlying psychopathology are successfully addressed. Possible memory impairments may, however, be found in those taking SSRIs.

Activation of septal 5‐HT1A receptors alters spatial memory encoding, interferes with consolidation, but does not affect retrieval in rats subjected to a water‐maze task

“…Our findings might have some relevance to approaches relying upon the modification of serotonergic functions in the brain for treating disorders such as e.g., depression, anxiety, or post-traumatic stress. Concerning depression, for instance, selective serotonin reuptake inhibitors (SSRI) have the best safety record among the different therapeutic options (van Laar et al, 2002), but there is a literature reporting on possible SSRI-related memory problems (Goodnick and Goldstein, 1998;Joss et al, 2003;Wadsworth et al, 2005). Although these memory problems could be related to various confounding factors (subject's history, age, existence of age-related cognitive dysfunctions.…”

Long-Term Neuropsychological Safety of Subgenual Cingulate Gyrus Deep Brain Stimulation for Treatment-Resistant Depression

“…[7][8][9][10][11] Clinical evaluation using neuropsychological measures appears clearly warranted in light of the following: 1) scarce data on long-term neuropsychological function following DBS for TRD; 2) previous findings that implicate the SCG in cognitive and memory function 12 ; 3) inconsistent findings that other treatments for depression (such as ECT or certain classes of antidepressant medications) are associated with cognitive impairment 13,14 ; and 4) previous findings suggesting that DBS for Parkinson's disease may result in mild cognitive deficits depending on surgical trajectory and electrode location. 15,16 Unfortunately, because of the relative novelty of this intervention for TRD, there have been no reliable data that describe long-term cognitive outcomes beyond the typical 12-month endpoint in studies of DBS for depression.…”

Use and impact of antidepressants in the school setting

“…Kent, Coplan, and Gorman (1988) reiterated this suggestion by noting that changes in cognitive processing associated with SSRIs may occur earlier in treatment than the therapeutic effect can occur, suggesting that changes in psychological function precede the improvement in psychopathology (Harmer et al, 2004). This suggestion is similar to that of Wadsworth, Moss, Simpson, and Smith (2005) in which they state that recall may be impaired among those taking SSRIs whose symptoms have not (yet) resolved, leading to fewer words correctly recalled, and more false alarms made. However, among those taking SSRIs whose symptoms are controlled, fewer words may be recalled correctly, but fewer false alarms are also made.…”