This study takes the Dongguashan Copper Mine as its engineering background. Based on the mechanical model of the mine wall under the trapezoidal load of the backfill, a comprehensive evaluation index is proposed, and its calculation equation is derived. On this basis, an orthogonal test is designed to explore the influence of mining design parameters on mine wall stability. The results show that the width of the mine wall is the main factor affecting its stability, and increasing the width of the mine wall can significantly improve its stability. When the width of the mine wall is kept above 4 m, its stability is better. When the mechanical parameters of the backfill are poor, the mine wall is prone to overturning failure. The width of the mine room has an influence on the multi-directional loading of the mine wall, but the influence on the stability of the mine wall is low. According to the regression equation calculation, the mine wall safety factor is about 1.46 under the design of G5 mining of Dongguashan Line 52, the stability of the mine wall is good after actual mining and the engineering application effect is ideal, which can provide a theoretical basis for the design of isolation pillar mining in deep mines.