Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers

Feliu, Neus; Walter, Marie V.; Montañez, María Isabel; Kunzmann, Andrea; Hult, Anders; Nyström, Andreas M.; Malkoch, Michael; Fadeel, Bengt

doi:10.1016/j.biomaterials.2011.11.054

Cited by 148 publications

(142 citation statements)

References 48 publications

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“…10 On this ground, with the aim of preparing hydrolyzable dendrimer structures which were, at the same time, adequately protonated but also well tolerated by the cells and which could harmonize transfection capacity with a low level of toxicity, we report in this work versatile chemical protocols for the synthesis of a library of 15 dendrimers of fourth, fifth and sixth generation derived from 2,2-bis(hydroxymethyl)propanoic acid (bis-HMPA), a monomer of the AB 2 type used to prepare a variety of dendritic architectures. 37 The prepared dendrimers have an internal polyester structure known for its biocompatibility 38 and contain at the surface a set of amino acid residues, natural or not, alone or in combination which can be protonated at physiological pH thus making dendrimers able to bind DNA, to enter into the cells and to escape the endosomal compartment as soon as possible to avoid degradation.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Alfei¹,

Castellaro²,

Taptue³

2017

Org. Commun.

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Dendrimers, the emerging man made, highly branched, star-shaped macromolecules with nanometerscale dimensions are well known for their well defined and high controlled architecture, their versatility and high functionality and are of eminent interest in nanomedical applications such as drug delivery, gene transfection, and imaging. In this paper, versatile protocols for the synthesis of polyester-based, hydrolysable, polycationic dendrimers have been setup. A fourth generation dendrimer equipped with 48 peripheral hydroxyl groups was prepared from 2,2-bis(hydroxymethyl)propanoic acid and was used for grafting BOC-amino acids or as "hypercores" on which dendrons functionalized with BOC-amino acids were attached. A library of 15 polycationic homo-and hetero-dendrimers in the form of hydrochloride was obtained. Their structures and composition were confirmed by NMR analysis and by experimental molecular weight computed by volumetric titration. Their buffer capacity and results obtained from cytotoxicity assays and tests of binding with both pDNA and siRNA were very satisfactory. Keywords:Polyester-based polycationic dendrimers; 2, 2-bis(hydroxymethyl)propanoic acid; amino acids; pDNA and siRNA binding; buffer capacity.

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Section: Introductionmentioning

confidence: 99%

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Alfei¹,

Castellaro²,

Taptue³

2017

Org. Commun.

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“…In another recent study, Malkoch, Fadeel and coworkers elegantly evaluated the biocompatibility of a library of aliphatic polyester dendrimers based on bis-HMPA [59]. In addition, dendrimers with two different chemical surfaces (neutral with hydroxyl end group and anionic with carboxylic end group) and dendrons corresponding to the structural fragments of the dendrimers were also evaluated.…”

Section: Methodsmentioning

confidence: 99%

“…The success of dendritic nanoparticles for drug delivery applications largely depends on the ability of scientists to design smart carriers with the ability to overcome drug leakage, immunogenicity, cytotoxicity, reticuloendothelial system uptake, and hemolytic toxicity among other shortcomings. One strategy to overcome these shortcomings is to use polyester dendrimers which have been shown to be non-toxic and biocompatible [19,[56][57][58][59][60]. By attaching a drug to a suitable carrier, it is possible to enhance its aqueous solubility, increase its circulation half-life, target certain tissues, improve drug transit across biological barriers, and slow drug metabolism [61][62][63][64][65][66].…”

Section: Introductionmentioning

confidence: 99%

Polyester Dendrimers: Smart Carriers for Drug Delivery

Twibanire

Grindley

2014

Polymers

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Polyester dendrimers have been shown to be outstanding candidates for biomedical applications. Compared to traditional polymeric drug vehicles, these biodegradable dendrimers show excellent advantages especially as drug delivery systems because they are non-toxic. Here, advances on polyester dendrimers as smart carriers for drug delivery applications have been surveyed. Both covalent and non-covalent incorporation of drugs are discussed.

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“…As a matter of fact, stability and biocompatibility of nanomaterials are ongoing issues in preclinical and clinical applications. For instance, Feliu et al (2012) analyse stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers. They: "evaluate material stability as a function of pH, temperature, and time, demonstrated that the stability of the 4 th generation hydroxyl functional bis-MPA [methylol-propionic acid] dendrimer increased at acidic pH.…”

Section: Theoretical Frameworkmentioning

confidence: 99%

Emerging nanotechnological research for future pathways of biomedicine

Coccia

Finardi

2012

IJBNN

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Abstract:The purpose of this paper is to measure and analyse the rate of scientific and technological advance of some emerging nanotechnological research fields in biomedicine to detect path-breaking technological trajectories. The approach, based on exponential models of growth, shows the current evolutionary trends of nano-research that may underpin future patterns of technological innovation in biomedicine and nanomedicine. In particular, results show that biosensors, quantum dots, carbon nanotubes and nanomicelles have innovative applications in diagnostics and targeted therapies for cancers that have been generating a revolution in clinical practice. The present study also detects two main determinants that have been supporting continuous diffusion of nano-technology in biomedicine: convergence of genetics, genomics and nanotechnology and multiplicity of learning processes in clinical research/practice. These drivers have been paving groundbreaking pathways in biomedicine that can lead to longer, better and healthier living of societies in not-too-distant future.

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Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers

Cited by 148 publications

References 48 publications

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Synthesis and NMR characterization of dendrimers based on 2, 2-bis-(hydroxymethyl)-propanoic acid (bis-HMPA) containing peripheral amino acid residues for gene transfection

Polyester Dendrimers: Smart Carriers for Drug Delivery

Emerging nanotechnological research for future pathways of biomedicine

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