Stability and freeze-drying of cyclosporine loaded poly(d,l lactide–glycolide) carriers

Chacón, M.; Molpeceres, Jesús; Berges, L; Guzmán, M.; Aberturas, M.R.

doi:10.1016/s0928-0987(98)00066-9

Cited by 157 publications

(85 citation statements)

References 29 publications

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“…The PLA-PEG was then used to synthesize particles by the W/O/O method in the same manner described above, using the bench-top sonicator for both sonication steps. The addition of trehalose as a cryoprotectant during freezing and freeze drying aided in stabilizing particles against agglomeration, as suggested by other investigators (32,33).…”

Section: Methodsmentioning

confidence: 81%

Preparation and initial characterization of biodegradable particles containing gadolinium-DTPA contrast agent for enhanced MRI

Doiron

Chu

Ali

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Accurate imaging of atherosclerosis is a growing necessity for timely treatment of the disease. Magnetic resonance imaging (MRI) is a promising technique for plaque imaging. The goal of this study was to create polymeric particles of a small size with high loading of diethylenetriaminepentaacetic acid gadolinium (III) (Gd-DTPA) and demonstrate their usefulness for MRI. A water-in-oil-in-oil double emulsion solvent evaporation technique was used to encapsulate the MRI agent in a poly(lactide-co-glycolide) (PLGA) or polylactide-poly(ethylene glycol) (PLA-PEG) particle for the purpose of concentrating the agent at an imaging site. PLGA particles with two separate average sizes of 1.83 m and 920 nm, and PLA-PEG particles with a mean diameter of 952 nm were created. Loading of up to 30 wt % Gd-DTPA was achieved, and in vitro release occurred over 5 h. PLGA particles had highly negative zeta potentials, whereas the particles incorporating PEG had zeta potentials closer to neutral. Cytotoxicity of the particles on human umbilical vein endothelial cells (HUVEC) was shown to be minimal. The ability of the polymeric contrast agent formulation to create contrast was similar to that of Gd-DTPA alone. These results demonstrate the possible utility of the contrast agent-loaded polymeric particles for plaque detection with MRI.atherosclerosis ͉ imaging ͉ targeted ͉ PLGA ͉ PEG

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Section: Methodsmentioning

confidence: 81%

Preparation and initial characterization of biodegradable particles containing gadolinium-DTPA contrast agent for enhanced MRI

Doiron

Chu

Ali

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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“…Consequently, by varying the molecular weight, the degradation rate of the polymer and release kinetics of the drug can be managed (Jain, 2000;Mittal et al, 2007;Dinarvand et al, 2011). The molecular weight determined by Size exclusion chromatography (Chacon et al, 1999;Garinot et al, 2007;Danhier et al, 2009).…”

Section: Nanoparticle Characterization Techniquesmentioning

confidence: 99%

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Mirakabad

Nejati-Koshki²,

Akbarzadeh³

et al. 2014

Asian Pacific Journal of Cancer Prevention

406

154

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“…Size exclusion chromatography [58][59][60] Surface chemistry analysis X-ray photoelectron spectroscopy 28,61,62 Fourier transform infrared spectroscopy 54,63,64 Nuclear magnetic resonance spectroscopy [64][65][66] Surface charge Zetasizer 56,67,68 Crystallinity X-ray diffraction 37,69,70 Differential scanning calorimetry [71][72][73] Hydrophobicity, hydrophilicity water contact angle measurements 65,74,75 Hydrophobic interaction chromatography [76][77][78] Drug entrapment efficiency, drug release studies…”

Section: Molecular Weightmentioning

confidence: 99%

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

Dinarvand¹,

Sepehri²,

Manoochehri³

et al. 2011

IJN

396

265

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The effectiveness of anticancer agents may be hindered by low solubility in water, poor permeability, and high efflux from cells. Nanomaterials have been used to enable drug delivery with lower toxicity to healthy cells and enhanced drug delivery to tumor cells. Different nanoparticles have been developed using different polymers with or without surface modification to target tumor cells both passively and/or actively. Polylactide-co-glycolide (PLGA), a biodegradable polyester approved for human use, has been used extensively. Here we report on recent developments concerning PLGA nanoparticles prepared for cancer treatment. We review the methods used for the preparation and characterization of PLGA nanoparticles and their applications in the delivery of a number of active agents. Increasing experience in the field of preparation, characterization, and in vivo application of PLGA nanoparticles has provided the necessary momentum for promising future use of these agents in cancer treatment, with higher efficacy and fewer side effects.

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Stability and freeze-drying of cyclosporine loaded poly(d,l lactide–glycolide) carriers

Cited by 157 publications

References 29 publications

Preparation and initial characterization of biodegradable particles containing gadolinium-DTPA contrast agent for enhanced MRI

Preparation and initial characterization of biodegradable particles containing gadolinium-DTPA contrast agent for enhanced MRI

PLGA-Based Nanoparticles as Cancer Drug Delivery Systems

Polylactide-co-glycolide nanoparticles for controlled delivery of anticancer agents

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