Objectives:The aim of the study was to evaluate the curve of Spee (COS) stability in patients treated with continuous archwires with different vertical patterns. Methods: The study sample consisted of 60 patients (28 males, 32 females; mean age 19.8 ± 1.4 years) presenting with COS depth of at least2 mm at baseline. For each subject, lateral cephalograms and dental casts were available before treatment (T1), at the end of orthodontic therapy (T2), and 2 years after the end of treatment (T3). All subjects were divided into three groups according to vertical facial patterns. Cephalometric parameters were used to evaluate the dental movements after treatment. COS depth was measured on digital casts. Mean differences between vertical facial subgroups were contrasted by means of analysis of variance test (P < 0.01). Results: In low-angle subjects, COS levelling occurred through advancement and intrusion of lower incisors, whereas in high-angle patients, the COS was flattened through extrusion and uprighting of lower posterior teeth. In the low-angle group, a significant relapse of lower incisors inclination was observed. Differently, the high-angle group exhibited a greater stability of COS obtained by stable extrusion of posterior teeth. Conclusions: The long-term instability of flared incisors determined the relapse of overbite and COS depth in the low-angle group.