We prove large deviation principles (LDPs) for random matrices in the orthogonal group and Stiefel manifold, determining both the speed and good convex rate functions that are explicitly given in terms of certain log-determinants of trace-class operators and are finite on the set of Hilbert-Schmidt operators M satisfying M M * < 1. As an application of those LDPs, we determine the precise large deviation behavior of k-dimensional random projections of highdimensional product distributions using an appropriate interpretation in terms of point processes, also characterizing the space of all possible deviations. The case of uniform distributions on ℓ p -balls, 1 ≤ p ≤ ∞, is then considered and reduced to appropriate product measures. Those applications generalize considerably the recent work [Johnston, Kabluchko, Prochno: Projections of the uniform distribution on the cube -a large deviation perspective, Studia Mathematica (2021+)].