Stability, Growth, and Decline in Adult Life Span Development of Declarative Memory: Cross-Sectional and Longitudinal Data From a Population-Based Study.

Rönnlund, Michael; Nyberg, Lars; Bäckman, Lars; Nilsson, Lars‐Göran

doi:10.1037/0882-7974.20.1.3

Cited by 747 publications

(679 citation statements)

References 96 publications

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“…The relationships between age and the cognitive variables seem to be in line with previous findings from Western samples (e.g., Nyberg, et al, 2003;Rönnlund, Nyberg, Bäckman, & Nilsson, 2005). Similar to such studies, semantic knowledge was the least age sensitive and recall was the most age sensitive.…”

Section: Discussionsupporting

confidence: 89%

Different Context but Similar Cognitive Structures: Older Adults in Rural Bangladesh

Sternäng

Lövdén

Kabir

et al. 2016

J Cross Cult Gerontol

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Most research in cognitive aging is based on literate participants from high-income and Western populations. The extent to which findings generalize to low-income and illiterate populations is unknown. The main aim was to examine the structure of between-person differences in cognitive functions among elderly from rural Bangladesh. We used data from the Poverty and Health in Aging (PHA) project in Bangladesh. The participants (n = 452) were in the age range 60-92 years. Structural equation modeling was used to estimate the fit of a five-factor model (episodic recall, episodic recognition, verbal fluency, semantic knowledge, processing speed) and to examine whether the model generalized across age, sex, and literacy. This study demonstrates that an established model of cognition is valid also among older persons from rural Bangladesh. The model demonstrated strong (or scalar) invariance for age, and partial strong invariance for sex and literacy. Semantic knowledge and processing speed showed weak (or metric) sex invariance, and semantic knowledge demonstrated also sensitivity to illiteracy. In general, women performed poorer on all abilities.The structure of individual cognitive differences established in Western populations also fits a population in rural Bangladesh well. This is an important prerequisite for comparisons of cognitive functioning (e.g. declarative memory) across cultures. It is also worth noting that absolute sex differences in cognitive performance among rural elderly in Bangladesh differ from those usually found in Western samples.

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Section: Discussionsupporting

confidence: 89%

Different Context but Similar Cognitive Structures: Older Adults in Rural Bangladesh

Sternäng

Lövdén

Kabir

et al. 2016

J Cross Cult Gerontol

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“…In conclusion, we report that the DRD2 and NR3A genes exert interactive effects on episodic memory performance in older adults, contributing to the commonly observed increased interindividual cognitive variation in old age (de Frias et al, 2007;Rönnlund et al, 2005). To our knowledge, this is the first evidence of interactive effects between genes related to the DA and glutamate systems on human episodic memory.…”

Section: Discussionsupporting

confidence: 51%

Dopamine and glutamate receptor genes interactively influence episodic memory in old age

Papenberg¹,

Li²,

Nagel³

et al. 2014

Neurobiology of Aging

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a b s t r a c tBoth the dopaminergic and glutamatergic systems modulate episodic memory consolidation. Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance. Given that individual differences in episodic memory are heritable, we investigated whether variations of the dopamine D2 receptor gene (rs6277, C957T) and the N-methyl-D-aspartate 3A (NR3A) gene, coding for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor (rs10989591, Val362Met), interactively modulate episodic memory in large samples of younger (20e31 years; n ¼ 670) and older (59e71 years; n ¼ 832) adults. We found a reliable gene-gene interaction, which was observed in older adults only: older individuals carrying genotypes associated with greater D2 and N-methyl-D-aspartate receptor efficacy showed better episodic performance. These results are in line with findings showing magnification of genetic effects on memory in old age, presumably as a consequence of reduced brain resources. Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory.

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“…It is becoming widely recognized that medial temporal lobe dependent (declarative) memory declines progressively across the lifespan, generally reaching the detection threshold at middleage [1,35,43]. Few rodent models have successfully modeled the typical human onset of cognitive dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Spatial reference and working memory across the lifespan of male Fischer 344 rats

Bizon

LaSarge

Montgomery

et al. 2009

Neurobiology of Aging

134

183

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Loss of mnemonic function is among the earliest and most disconcerting consequences of the aging process. This study was designed to provide a comprehensive profile of spatial mnemonic abilities in male Fischer 344 (F344) rats across the lifespan. Young, middle-aged, and aged F344 rats were trained in spatial reference and working memory versions of the water maze task. There was a progressive age-related decline in spatial reference memory across the lifespan. Reliable individual differences were observed among aged rats, with some aged rats performing as well as young cohorts and other performing outside this range. An age-related delay-dependent decline was observed on a working memory version of the water maze task although no relationship between performance on reference and working memory tasks was present. Notably, middle-aged rats were impaired relative to young on both tasks. Together these data demonstrate that individual differences in spatial reference memory exist among aged F344 rats and provide novel data demonstrating an unrelated decline in working memory across the lifespan, suggesting that age-related mnemonic dysfunction may occur across multiple brain systems.

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Stability, Growth, and Decline in Adult Life Span Development of Declarative Memory: Cross-Sectional and Longitudinal Data From a Population-Based Study.

Cited by 747 publications

References 96 publications

Different Context but Similar Cognitive Structures: Older Adults in Rural Bangladesh

Different Context but Similar Cognitive Structures: Older Adults in Rural Bangladesh

Dopamine and glutamate receptor genes interactively influence episodic memory in old age

Spatial reference and working memory across the lifespan of male Fischer 344 rats

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