Stability-Indicating Quantification of Ciprofloxacin in the Presence of Its Main Photo-Degradation Product by CZE and UPLC: A Comparative Study

Alabbas, Alhumaidi B.; Abdel-Gawad, Sherif A.

doi:10.3390/separations10070391

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Ciprofloxacin is a popular antibiotic used in human and veterinary medicine, and it can be found in various concentrations in wastewater, hospitals, and pharmaceutical industries. Although some of it is metabolized, much is excreted into the environment and can be detected in different environmental samples 3 , 4 . Unfortunately, most sewage treatment plants cannot remove it, prompting the need for effective new strategies 5 , 6 .…”

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confidence: 99%

Fabrication of new composite NCuTiO2/CQD for photocatalytic degradation of ciprofloxacin and pharmaceutical wastewater treatment: degradation pathway, toxicity assessment

Noroozi,

Gholami,

Oskoei

et al. 2023

Sci Rep

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In this research, the photocatalytic degradation of CIP from aqueous solutions using CQD decorated on N-Cu co-doped titania (NCuTCQD) was made during two synthesis steps by sol–gel and hydrothermal methods. The fabricated catalysts were analyzed using various techniques, including XRD, FT-IR, BET, FESEM, EDX, and DRS. The results showed that N and Cu atoms were doped on TiO2 and CQD was well deposited on NCuT. The investigation of effective operational parameters demonstrated that the complete removal of ciprofloxacin (CIP: 20 mg/L) could be achieved at pH 7.0, NCuTCQD4wt%: 0.8 g/L, and light intensity: 100 mW/cm2 over 60 min reaction time. The O2•– and OH˙ radicals were identified as the primary reactive species during the decontamination process. The synthesized photocatalyst could be recycled after six consecutive cycles of CIP decomposition with an insignificant decrease in performance. Pharmaceutical wastewater was treated through the optimum degradation conditions which showed the photocatalytic degradation eliminated 89% of COD and 75% of TOC within 180 min. In the effluent toxicity evaluation, the EC50 values for treated and untreated pharmaceutical wastewater increased from 62.50% to 140%, indicating that the NCuTCQD4wt%/Vis system can effectively reduce the toxic effects of pharmaceutical wastewater on aquatic environments.

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Section: Introductionmentioning

confidence: 99%

Fabrication of new composite NCuTiO2/CQD for photocatalytic degradation of ciprofloxacin and pharmaceutical wastewater treatment: degradation pathway, toxicity assessment

Noroozi,

Gholami,

Oskoei

et al. 2023

Sci Rep

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Antibiotic Removal by Three Promising Microalgae Strains: Biotic, Abiotic Routes, and Response Mechanisms

Frascaroli,

Hunter,

Roberts

et al. 2024

Water Air Soil Pollut

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Microalgae represent an alternative to conventional wastewater treatment, potentially improving antibiotic removal and offering a solution to combat the spread of antimicrobial resistance. Through batch assays, this study investigates the routes for antibiotic removal using three strains (Chlamydomonas acidophila, Auxhenochlorella protothecoides and Tetradesmus obliquus). Using mixtures of ciprofloxacin, clarithromycin, erythromycin, metronidazole, ofloxacin, sulfamethoxazole, and trimethoprim at concentrations simulating wastewater composition, it also assesses antibiotic effects on microalgae physiology. The three strains primarily removed antibiotics through rapid biosorption, achieving up to 91.5% removal for specific ones like ciprofloxacin. T. obliquus and C. acidophila showed efficacy, with total removals of 37.2% and 49.3%, respectively. Over time, A. protothecoides demonstrated the highest active removal efficiency, eliminating 22.1% of total antibiotics, with a notable 67.6% removal for sulfamethoxazole. Abiotic degradation through hydrolysis and photolysis contributed to ciprofloxacin, ofloxacin, clarithromycin, and erythromycin removal (34.7% to 96.7%), showing pH-dependent photolysis. However, algae induced a shading effect, reducing the photolytic and hydrolytic degradation of specific antibiotics. T. obliquus and C. acidophila were inhibited by antibiotics, whereas A. protothecoides showed a 30.6% growth rate increase. The stimulatory effect was also observed for the nutrient removal, with A. protothecoides showing a 46.6% increase in ammonium removal and a 44.8% increase in phosphate removal with antibiotics. Additionally, antioxidant activities remained stable, except for a notable increase in peroxidase activity for A. protothecoides and T. obliquus. The study confirms efficient antibiotic removal and stimulatory responses in the three algal strains, indicating their potential for wastewater treatment and combating antimicrobial resistance.

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Stability-Indicating Quantification of Ciprofloxacin in the Presence of Its Main Photo-Degradation Product by CZE and UPLC: A Comparative Study

Cited by 2 publications

References 24 publications

Fabrication of new composite NCuTiO2/CQD for photocatalytic degradation of ciprofloxacin and pharmaceutical wastewater treatment: degradation pathway, toxicity assessment

Fabrication of new composite NCuTiO2/CQD for photocatalytic degradation of ciprofloxacin and pharmaceutical wastewater treatment: degradation pathway, toxicity assessment

Antibiotic Removal by Three Promising Microalgae Strains: Biotic, Abiotic Routes, and Response Mechanisms

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