Stability indicating spectrophotometric methods for determination of glafenine using first derivative of ratio spectra and chemometric techniques

El‐Ragehy, Nariman A.; Abbas, Samah S.; El-khateeb, Sonia Z.

doi:10.1016/s0003-2670(02)00232-5

Cited by 11 publications

(4 citation statements)

References 24 publications

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“…The evaluation of the predictive abilities of the models was performed by plotting the actual known concentrations against the predicted concentrations [20]. The results are obtained in Table 1.…”

Section: Pcr and Pls-1 Methodsmentioning

confidence: 99%

HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid

El‐Gindy

El-Yazby

Mostafa

et al. 2004

Journal of Pharmaceutical and Biomedical Analysis

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Section: Pcr and Pls-1 Methodsmentioning

confidence: 99%

HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid

El‐Gindy

El-Yazby

Mostafa

et al. 2004

Journal of Pharmaceutical and Biomedical Analysis

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“…The first derivatives of the absorption spectra were obtained to allow quantitative determination of oxfendazole in the presence of its degradation product, where the amplitudes at 298.9 nm are proportional to the concentrations of oxfendazole without interference from its degradation product, as shown in Figures 6, 7. First derivative of ratio spectra 20,21 First derivative of ratio spectra method is a simple method, capable of determining oxfendazole in presence of its alkali-induced degradation product with minimal data processing. In this method, the absorption spectra of the drug were divided by the absorption spectrum of the degradation product (10 μg mL -1 ), as a divisor, to get the ratio spectra, as shown in Figure 8.…”

Section: Spectral Characteristicsmentioning

confidence: 99%

Development and Validation of Spectrophotometric Methods for Quantitative Estimation of Oxfendazole in Presence of Its Alkali-induced Degradation Product: A Comparative Study

Salama

Attia

Mohamad

et al. 2017

Journal of Advanced Pharmacy Research

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Objectives: This study aimed to develop and validate three simple, accurate, selective, reproducible and sensitive spectrophotometric methods for the determination of oxfendazole in the presence of its alkali-induced degradation product without preliminary separation. Methods: (A) first derivative spectrophotometry ( 1 D) method at 298.9 nm, (B) first derivative of ratio spectra ( 1 DD) method at 295.4 nm and (C) area under the curve (AUC) method at wavelength ranges of (290-294 nm) and (297-301 nm). All methods were applied in the range of (1-10µg mL -1 ). Results: These methods were validated and successfully applied for determination of oxfendazole in Unifendazole® suspension. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95% confidence level and no significant difference was observed regarding accuracy and precision. Conclusion: The proposed methods are simple, rapid, economic, accurate and precise to determine oxfendazole in the presence of its alkali-induced degradation product without previous separation steps.

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“…The aim of this work is to develop and validate simple, sensitive, selective and cost effective spectrophotometric methods for the determination of tetramisole hydrochloride in the presence of its alkali-induced degradation product without preliminary separation. These methods namely ratio difference [11,12], derivative ratio [13,14], mean centering [15,16] and continuous wavelet transform [17,18].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Spectrophotometric Methods Manipulating Ratio Spectra for Determination of Tetramisole Hydrochloride in the Presence of its Alkali-Induced Degradation Product

Nassar¹,

Attia²,

Mohamad³

et al. 2018

JAPLR

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Tokyo, Japan), equipped with 10 mm matched quartz cells. The bundled software, UV-Probe personal spectroscopy software version 2.21 (SHIMADZU). Mean centering and continuous wavelet transform were implemented in MATLAB 8.2.0.701 (R2013b) using PLS toolbox version 2.1. The t-test and F-test were performed using Microsoft Excel. Samples Both pure tetramisole hydrochloride (99.8%) (B. NO.20160920) and Anthimizole ® 10% veterinary powder (B. NO. 150632) were kindly supplied by Pharma-Swede, Egypt. 10 th of Ramadan city, Egypt. Chemicals and solvents Hydrochloric acid, sodium hydroxide and methanol (El-Nasr Co., Egypt). Solvent used throughout the work was distilled water. Standard solution A stock solution of tetramisole hydrochloride (100µg/ml) was prepared by dissolving 10mg of tetramisole hydrochloride in 50ml of distilled water and complete to 100ml with the same solvent. Degraded sample Accelerated alkali-induced degradation was performed by refluxing 100mg of pure tetramisole hydrochloride with 50mL of 1N sodium hydroxide solution for 2 hours. The solution was cooled to room temperature then neutralized to pH 7 by addition of 1N hydrochloric acid solution, and then evaporated to dryness under vacuum. The obtained residue was extracted with methanol Volume 7 Issue 1-2018

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Stability indicating spectrophotometric methods for determination of glafenine using first derivative of ratio spectra and chemometric techniques

Cited by 11 publications

References 24 publications

HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid

HPLC and chemometric methods for the simultaneous determination of cyproheptadine hydrochloride, multivitamins, and sorbic acid

Development and Validation of Spectrophotometric Methods for Quantitative Estimation of Oxfendazole in Presence of Its Alkali-induced Degradation Product: A Comparative Study

Development and Validation of Spectrophotometric Methods Manipulating Ratio Spectra for Determination of Tetramisole Hydrochloride in the Presence of its Alkali-Induced Degradation Product

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