Stability of Antibacterial Preservatives in Parenteral Solutions I

Introduction

“…As a result, the percent solids in the formulation may be significantly < 2%. mannitol becomes crystalline [24][25][26][27][28]. This figure shows that during the drying process, the poor structural properties of the cake resulted in some of the product being carried out of the container as a result of the gas flow during the dry ing process.…”

“…Perhaps the most common bulking agent used in formulations is mannitol[24][25][26], An important advantage of mannitol is that if the formulation is frozen slowly, the Downloaded by [University of Cincinnati] at 05:53 04 June 2016…”

Elastomeric Closures for Pharmaceutical Packaging

“…In fact, Jones (53) reports that a recent postgraduate school for English pharmacists on "the stability of pharmaceutical preparations" lasted 1 week without covering the subject. Garrett (54) and Lachman (19,20) are two of the most prolific contributors in recent years.…”

Ultraviolet Spectrometry

“…A method was developed for analysis of ternary mixtures (82), and the prediction of drug and formulation stabilities from measurements at elevated temperatures was reviewed (38). The factors involved in preparation of clear injectable solutions of Warfarin were examined in one study (50), and the effects of various types of vial closures on selfsterilizing agents in another (62). scintillation detector with a gold cathode.…”