Stability of cefazolin sodium in icodextrin-containing peritoneal dialysis solution

Lin, Yuh Feng; Wu, Chia‐Chao; Lin, Shih Hua; Wang, Da Peng; Wang, Chao Nin

doi:10.1093/ajhp/59.23.2362

Cited by 8 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The stability of cephazolin or ceftazidime in different types of PD fluids has been investigated before (11)(12)(13)(14)(15). Cephazolin (500 mg/L) is reported to be stable in icodextrin or dextrose PD fluid for at least 336 and 24 hours at 4 and 37°C respectively.…”

Section: Discussionmentioning

confidence: 99%

Stability of the Combination of Ceftazidime and Cephazolin in Icodextrin or PH Neutral Peritoneal Dialysis Solution

et al. 2013

View full text Add to dashboard Cite

♦ Introduction: The objective of this study was to inves ti gate the stability of ceftazidime and cephazolin in a 7.5% icodextrin or pH neutral peritoneal dialysis (PD) solution. ♦ Methods: Ceftazidime and cephazolin were injected into either a 7.5% icodextrin or pH neutral PD bag to obtain the concentration of 125 mg/L of each antibiotic. A total of nine 7.5% icodextrin or pH neutral PD bags containing ceftazidime and cephazolin were prepared and stored at 1 of 3 different temperatures: 4°C in a domestic refrigerator; 25°C at room temperature; or 37°C (body temperature) in an incubator. An aliquot was withdrawn immediately before (0 hour) or after 12, 24, 48, 96, 120, 144, 168 and 336 hours of storage. Each sample was analyzed in duplicate for the concentration of ceftazidime and cephazolin using a stabilityindicating highperformance liquid chromatography technique. Ceftazidime and cephazolin were considered stable if they retained more than 90% of their initial concentration. Samples were also assessed for pH, colour changes and evidence of precipitation immediately after preparation and on each day of analysis. ♦ Results: Ceftazidime and cephazolin in both types of PD solution retained more than 90% of their initial concentration for 168 and 336 hours respectively when stored at 4°C. Both of the antibiotics lost more than 10% of the initial concentration after 24 hours of storage at 25 or 37°C. There was no evidence of precipitation at any time under the tested storage conditions. Change in the pH and color was observed at 25 and 37°C, but not at 4°C. ♦ Conclusion: Premixed ceftazidime and cephazolin in a 7.5% icodextrin or pH neutral PD solution is stable for at least 168 hours when refrigerated. This allows the prepa ration of PD bags in advance, avoiding the necessity for daily preparation. Both the antibiotics are stable for at least 24 hours at 25 and 37°C, permitting storage at room temperature and prewarming of PD bags to body tempera ture prior to its administration.

show abstract

Section: Discussionmentioning

confidence: 99%

Stability of the Combination of Ceftazidime and Cephazolin in Icodextrin or PH Neutral Peritoneal Dialysis Solution

et al. 2013

View full text Add to dashboard Cite

show abstract

“…To reflect the recommendations given in the SPCs, stability testing was performed for 24 hours at 25°C and for a further 4 hours at 37°C. The compatibility of several drugs in different PD solutions contained in polyvinyl chloride (PVC) material has been reported in the literature (3-7). The PD solutions evaluated in this study are contained in single- and double-chambered bags made of Clear-Flex, which comprises five co-extruded layers of different polyolefins.…”

mentioning

confidence: 99%

Stability of Drug Additives in Peritoneal Dialysis Solutions in a New Container

et al. 2004

View full text Add to dashboard Cite

Objective To evaluate the stability of gentamicin, tobramycin, netilmycin, vancomycin, cefazolin, unfractionated heparin, and low molecular weight heparin when added to four different peritoneal dialysis (PD) solutions [Extraneal (Baxter Healthcare, Castlebar, Ireland); Physioneal, Nutrineal, and Dianeal (Baxter Healthcare, Grosotto, Italy)] in new, non-PVC Clear-Flex containers. Measurements Gentamicin, tobramycin, netilmycin, vancomycin, cefazolin, unfractionated heparin, and low molecular weight heparin were injected into separate bags of PD solution. Samples were withdrawn at predefined sampling times and the concentration of each drug was analyzed using high-performance liquid chromatography (for gentamicin, tobramycin, vancomycin, and cefazolin), or bioassay (for netilmycin, gentamicin, and tobramycin in Nutrineal), or coagulation methods (heparins). Results Netilmycin, vancomycin, cefazolin, and heparin in Physioneal, Nutrineal, Extraneal, and Dianeal were stable for at least 24 hours at 25°C and for an additional 4 hours at 37°C. Gentamicin in Nutrineal, Extraneal, and Dianeal was stable for at least 24 hours at 25°C and for an additional 4 hours at 37°C; gentamicin in Physioneal was stable for less than 24 hours at 25°C. Tobramycin in Nutrineal and Extraneal was stable for at least 24 hours at 25°C and for an additional 4 hours at 37°C; tobramycin in Physioneal and Dianeal was stable for less than 24 hours at 25°C.

show abstract

“…Robinson et al studied the stability of cefazolin (125 mg/L and 500 mg/L) in icodextrin at 38°C only for 4 days and found it to be stable for at least 48 hours (8). Lin et al determined stability of cefazolin (500 mg/L) only in icodextrin solution at 4°C and 25°C for 30 days and at 37°C for 24 hours and found cefazolin to be stable for 30 days at 4°C, 7 days at 25°C, and 24 hours at 37°C (11).These studies did not address the stability of combinations of antibiotics in icodextrin solution. Patel et al found that premixed ceftazidime (125 mg/L) and cefazolin (125 mg/L) in 7.5% icodextrin and pH neutral PD solution is stable for at least 7 days when refrigerated (10).…”

Section: Discussionmentioning

confidence: 99%

“…Whilst some antibiotics have demonstrated in vitro compatibility with icodextrin (3), data on drug stability are sparse. Previous studies on the stability of some antibiotics in icodextrin provide only minimal information because they do not fully cover the entire range of temperature storage conditions and likely storage time periods encountered in clinical practice (4)(5)(6)(7)(8)(9). Patel et al examined the stability of the combination of cefazolin and ceftazidime in icodextrin but did not study the combination of either cefazolin and gentamicin, vancomycin and ceftazidime, or gentamicin in icodextrin (10).…”

mentioning

confidence: 99%

Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (Stab Study)

et al. 2016

View full text Add to dashboard Cite

show abstract

Stability of cefazolin sodium in icodextrin-containing peritoneal dialysis solution

Cited by 8 publications

References 0 publications

Stability of the Combination of Ceftazidime and Cephazolin in Icodextrin or PH Neutral Peritoneal Dialysis Solution

Stability of the Combination of Ceftazidime and Cephazolin in Icodextrin or PH Neutral Peritoneal Dialysis Solution

Stability of Drug Additives in Peritoneal Dialysis Solutions in a New Container

Stability of Antibiotics for Intraperitoneal Administration in Extraneal 7.5% Icodextrin Peritoneal Dialysis Bags (Stab Study)

Contact Info

Product

Resources

About