Stability of ciprofloxacin in peritoneal dialysis solution

Mawhinney, W. M.; Adair, Colin G.; Gorman, S. P.; McClurg, B

doi:10.1093/ajhp/49.12.2956

Cited by 4 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tobramycin, however, was shown to be stable at 37°C for at least 8 hours in glucose-containing PDFs, for 24 hours in icodextrin-containing PDFs, and for 4 hours in amino acid-containing PDFs (19)(20)(21). Ciprofloxacin was shown to be stable at body temperature for several weeks in a glucose-based PDF, but no stability data are available for icodextrin-or amino acid-containing PDFs (22). In addition, a very recent study compared the stability of meropenem in different commercial PDFs and revealed that meropenem is markedly more stable in Extraneal than in Physioneal 40 (unpublished data).…”

Section: Discussionmentioning

confidence: 99%

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin against Escherichia Coli

et al. 2016

View full text Add to dashboard Cite

♦ BACKGROUND: Peritonitis is a major problem among patients on peritoneal dialysis (PD). The influence of diverse PD fluids on the activity of frequently used antibiotics has been insufficiently investigated. Thus, the present study set out to investigate the impact of different PD fluids on the activity of cefepime, ciprofloxacin, ertapenem, meropenem, and tobramycin against Escherichia coli. ♦ METHODS: Time-kill curves in 4 different PD fluids (Dianeal PDG4, Extraneal, Nutrineal PD4 and Physioneal 40, all Baxter Healthcare Corp., Deerfield, IL, USA) were performed over 24 hours with 4 different concentrations (1 × minimum inhibitory concentration [MIC], 4 × MIC, 8 × MIC, 30 × MIC) of each antibiotic evaluated and without antibiotics as control. Cation-adjusted Mueller Hinton broth (CA-MHB) was used as comparator solution. ♦ RESULTS: In all PD fluids investigated, bacterial growth and antimicrobial activity of all antibiotics tested was significantly reduced compared with the CA-MHB comparator solution. Except at high concentrations of 30 × MIC, cefepime, ertapenem and meropenem demonstrated a strongly reduced activity in all PD fluids investigated. Ciprofloxacin and tobramycin were highly active and bactericidal in all PD fluids and demonstrated dose-dependent activity. ♦ CONCLUSION: The antimicrobial activity of cefepime, ertapenem and meropenem is limited or even nullified in certain PD fluids in vitro, whereas ciprofloxacin and tobramycin show excellent activity. The choice of PD fluids can impact the activity of antimicrobial agents and might influence microbiological outcome. Further studies are required to verify the clinical relevance of our findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin against Escherichia Coli

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Mawhinney et al . investigated the stability of ciprofloxacin 25 mg/L in 1.36% glucose-containing PDFs over 42 days at 4 °C, 20 °C and 37 °C 21 . In that study, ciprofloxacin was stable at each storage condition over the whole study period 21 .…”

Section: Discussionmentioning

confidence: 99%

Compatibility of ciprofloxacin with commercial peritoneal dialysis solutions

Kussmann

Ferth

Obermüller

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Intraperitoneal administration of antibiotics together with peritoneal dialysis fluids (PDFs) remains the preferable route for treatment of peritoneal dialysis-related peritonitis. For home based therapy, antibiotic-containing PDFs are stored for up to two weeks and warmed up to body-temperature before administration. The present study investigated the compatibility of ciprofloxacin with five commercial PDFs at refrigeration-temperature, room-temperature and body-temperature. Ciprofloxacin concentrations were determined using high-performance liquid chromatography. Drug-diluent stability was evaluated by measurement of pH-values and visual inspection at each sampling point. The antimicrobial activity of ciprofloxacin was assessed by an E. coli disk diffusion method. Ciprofloxacin was stable at refrigeration-temperature and body-temperature in all PDFs evaluated over the whole study period of 14 days and 24 hours, respectively. At room-temperature, in contrast, ciprofloxacin demonstrated only limited stability in particular when tested in mixed Physioneal. Except for Physioneal 1.36%, no relevant drug adsorption was observed and the antimicrobial activity of ciprofloxacin was found to be preserved in each PDF at each storage condition investigated. Intraperitoneal ciprofloxacin might be used for inpatient and home based therapy of peritoneal dialysis-related peritonitis and no compensatory dose adjustment is needed when stored for up to two weeks at refrigeration-temperature before use.

show abstract

“…The dialysis solutions used in this work contains 514 mg of calcium chloride (approximately 7 mEq of calcium) and 304 mg of magnesium chloride (approximately 3 mEq of magnesium) per 2‐L bag. In dialysis solutions with 1·36% glucoseciprofloxacin does not form complexes with calcium or magnesium (9). Absence of significant drop in moxifloxacin concentration and absence of precipitation suggest that moxifloxacin like ciprofloxacin does not produce complexes with the metal cations.…”

Section: Methodsmentioning

confidence: 99%

“…Antibiotic stability studies in PD solutions for intraperitoneal treatment of peritonitis are scant. Some authors have reported stability of quinolones in PD solutions (8–10), but the stability of the newer fluorquinolones in PD solutions has yet to be shown.…”

Section: Introductionmentioning

confidence: 99%

Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%^®and Dianeal PD1 3·86%^®)

Fernández-Varón

Marı́n

Espuny

et al. 2006

Journal of Clinical Pharmacy and Therapeutics

View full text Add to dashboard Cite

show abstract

Stability of ciprofloxacin in peritoneal dialysis solution

Cited by 4 publications

References 0 publications

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin against Escherichia Coli

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin against Escherichia Coli

Compatibility of ciprofloxacin with commercial peritoneal dialysis solutions

Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%^®and Dianeal PD1 3·86%^®)

Contact Info

Product

Resources

About

Stability of ciprofloxacin in peritoneal dialysis solution

Cited by 4 publications

References 0 publications

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin against Escherichia Coli

Influence of Different Peritoneal Dialysis Fluids on the In Vitro Activity of Cefepime, Ciprofloxacin, Ertapenem, Meropenem and Tobramycin against Escherichia Coli

Compatibility of ciprofloxacin with commercial peritoneal dialysis solutions

Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%®and Dianeal PD1 3·86%®)

Contact Info

Product

Resources

About

Stability of moxifloxacin injection in peritoneal dialysis solution bags (Dianeal PD1 1·36%^®and Dianeal PD1 3·86%^®)