Stability of eosinophilic inflammation in COPD bronchial biopsies

Higham, Andrew; Leow-Dyke, Sophie; Jackson, Natalie; Singh, Dave

doi:10.1183/13993003.00622-2020

Cited by 18 publications

(13 citation statements)

References 12 publications

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“…In contrast, there is greater variation at higher BEC. A small study ( n = 14) reported that lower submucosal eosinophil counts in COPD bronchoscopic biopsies were relatively stable over time, while higher eosinophil counts show greater variation over time, with increased heterogeneity throughout the bronchial tree [ 18 ]. Chronic inflammation is a dynamic process, influenced by the interaction between external stimuli and internal homeostatic regulatory mechanisms [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts

2022

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Higher blood and sputum eosinophil counts are associated with a greater response to corticosteroids in COPD. Low blood eosinophil counts exhibit greater stability over time whereas higher counts demonstrate more variability. Stability of airway eosinophil levels is less well understood. We have studied the stability of sputum eosinophil counts. Differential cell count data for COPD patients (n = 100) were analysed. Subjects with two sputum eosinophil counts, 6 months apart, were included in the analysis. Patients were stratified based on baseline sputum eosinophil count into ‘low’, ‘intermediate’ and ‘high’ groups: eosinophilLOW (<1%), eosinophilINT (1–3%) and eosinophilHIGH (≥3%). Sputum eosinophil counts showed good stability (rho = 0.61, p < 0.0001, ICC of 0.77), with 67.4% of eosinophilLOW patients remaining in the same category on repeat sampling. Bland–Altman analysis of the whole cohort (median difference between measurements = 0.00%, 90th percentile = −1.4 and 4.7%) showed greater variation at higher counts. This was confirmed by the wider 90th centiles in the eosinophilINT (−1.50 to 5.65) and eosinophilHIGH groups (−5.33 to 9.80) compared to the eosinophilLOW group (−0.40 to 1.40). The repeatability of sputum eosinophil counts was related to the baseline eosinophil count; sputum eosinophilLOW COPD patients were relatively stable over time, while the eosinophilHIGH group showed greater variability. These results can facilitate the identification of COPD endotypes with differential responses to treatment.

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Section: Introductionmentioning

confidence: 99%

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts

2022

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“…An intraclass correlation coefficient (ICC) was used to estimate measurement repeatability [ 13 ]. Several studies chose ICC to evaluate the stability of BEC [ 2 , 6 , 14 – 17 ]. Many of these studies produced reassuring results of fair to good (0.40–0.75) or excellent (>0.75), which indicates that BEC stability was good ( Figure 4 ).…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing the Stability of Blood Eosinophils Counts in Chronic Obstructive Pulmonary Disease Patients

Cai

Wang

2022

Canadian Respiratory Journal

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Blood eosinophil (EOS) has recently been recognized as a biomarker for chronic obstructive pulmonary disease (COPD) patients. However, few studies have concentrated on the stability of blood eosinophil counts (BEC), and those studies have produced varying results. With further research, we have found minor drawbacks and vulnerabilities that lead to the variability of the results. This paper enumerates several areas of relevant research with varying conclusions to further investigate the stability of BEC in COPD patients.

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“…37 Nevertheless, a recent study has documented that low levels of submucosal eosinophilic airway inflammation in patients with COPD are highly stable over time, whereas high levels show increased biological variability over time. 38 An analysis of the COPDMAP observational cohort showed that approximately 70% of blood eosinophil measurements remained in the same category over 1 year using the GOLD 2019 thresholds (<100, 100-299 or ≥300 cells/μL), and 85.3% of patients with eosinophils <100 cells/μL had stable counts. 39 Also, the analysis of the German COPD and Systemic Consequences-Comorbidities Network (COSYCO-NET) cohort demonstrated that in COPD, non-eosinophilia (<150 eosinophils/µL) in blood is more robust over time than eosinophilia defined as a count of ≥300 cells/µL.…”

Section: The Stability Of Blood Eosinophil Countsmentioning

confidence: 99%

Blood Eosinophils in Chronic Obstructive Pulmonary Disease: Is There Enough Evidence?

Cazzola¹,

Matera²,

Rogliani³

2021

US Respiratory &Amp; Pulmonary Diseases

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Stability of eosinophilic inflammation in COPD bronchial biopsies

Cited by 18 publications

References 12 publications

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts

Identification of COPD Inflammatory Endotypes Using Repeated Sputum Eosinophil Counts

Factors Influencing the Stability of Blood Eosinophils Counts in Chronic Obstructive Pulmonary Disease Patients

Blood Eosinophils in Chronic Obstructive Pulmonary Disease: Is There Enough Evidence?

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