Stability of epidoxorubicin in solid state

Sobczak, Agnieszka; Jelińska, Anna; Lesniewska, Monika A; Firlej, Artur; Oszczapowicz, Irena

doi:10.1016/j.jpba.2010.10.024

Cited by 6 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The influence of temperature and relative air humidity on the stability of EP as well as of doxorubicin and daunorubicin in the solid state was previously reported [4,5]. The degradation of EP in the atmosphere of increased relative air humidity was a first-order reaction depending on the substrate concentration, and in dry, hot air (RH 0%; 393 K) a reversible first-order reaction relative to the substrate concentration.…”

Section: Introductionmentioning

confidence: 74%

“…Thus, the aim of this study was to evaluate the degradation of EP under the influence of pH and temperature and to develop equations permitting the estimation of kinetic and thermodynamic parameters. To separate EP and its degradation products, our previously designed HPLC method was used [4]. The geometric structure of EP molecule, FMOs orbitals (HOMO-LUMO; Highest Occupied Molecular Orbital; Lowest Unoccupied Molecular Orbital), and molecular electrostatic potential were also determined.…”

Section: Journal Of Chemistrymentioning

confidence: 99%

“…Chromatographic separation and quantitative analysis were performed by using the HPLC method [4]. The analytical system consisted of a Shimadzu SPD-20A Prominence UV/VIS detector, a Rheodyne with a 50 L loop.…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

“…The flow rate was 1.0 mL/min and UV detection was performed at 254 nm. As the HPLC method was previously evaluated and validated for a stability study of epidoxorubicin in the solid state [4], selectivity was examined during stability studies in aqueous solutions in this work. Papaverine hydrochloride was used as an internal standard at a concentration of 0.05 mg/mL.…”

Section: Chromatographic Conditionsmentioning

confidence: 99%

“…The degradation of EP in the atmosphere of increased relative air humidity was a first-order reaction depending on the substrate concentration, and in dry, hot air (RH 0%; 393 K) a reversible first-order reaction relative to the substrate concentration. The dependences ln = (1/ ) and ln = (RH%) were described by the equations ln = (35.1±10.9)− (16250 ± 3823)(1/ ) and ln = (3.79 ± 3.34) × 10 −2 (RH%) − (12.9 ± 2.4), respectively, and the kinetic and thermodynamic parameters of the above processes were calculated [4].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

Sobczak

Lesniewska-Kowiel

Muszalska

et al. 2017

Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

The first-order degradation kinetics of epidoxorubicin were investigated as a function of pH, temperature, and buffers concentrations. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles were obtained at 333, 343, 353, and 363 K. The pH-rate expression was pHwhere 1 , 4 , and 5 are the second-order rate constants (mol −1 L s −1 ) for hydrogen ion activity and for hydroxyl ion activity, respectively, and 2 and 3 are the first-order constants (s −1 ) for spontaneous reaction under the influence of water. Epidoxorubicin demonstrates the greatest stability in the pH range 3-5. The electrostatic molecular potential orbitals HOMO-LUMO were also defined in order to determine the cause of the reactivity of particular epidoxorubicin molecule domains in solutions with various pH values.

show abstract

Section: Introductionmentioning

confidence: 74%

Section: Journal Of Chemistrymentioning

confidence: 99%

Section: Chromatographic Conditionsmentioning

confidence: 99%

Section: Chromatographic Conditionsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

Sobczak

Lesniewska-Kowiel

Muszalska

et al. 2017

Journal of Chemistry

Self Cite

View full text Add to dashboard Cite

show abstract

Analysis of anticancer drugs: A review

Nussbaumer

Bonnabry

Veuthey

et al. 2011

Talanta

474

236

View full text Add to dashboard Cite

Antineoplastic drugs and their analysis: a state of the art review

Guichard

Guillarme

Bonnabry

et al. 2017

Analyst

View full text Add to dashboard Cite

The number of patients suffering from cancer is constantly increasing and, consequently, the number of different chemotherapy treatments administered is increasing. Given the high reactivity and toxicity of antineoplastic drugs, analytical methods are required in all pharmaceutical fields, from drug development to their elimination in wastewater; including formulation quality control, environment and human exposure and therapeutic drug monitoring. The aim of this paper is to provide an overview of the analytical methods available for the determination of antineoplastic drugs in different matrices such as pharmaceutical formulations, biological and environmental samples. The applicability and performance of the reported methods will be critically discussed, with focus on the most commonly used antineoplastic drugs. Only conventional compounds and small molecules for targeted therapy will be considered in the present review.

show abstract

Stability of epidoxorubicin in solid state

Cited by 6 publications

References 7 publications

Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

Stability of Epidoxorubicin Hydrochloride in Aqueous Solutions: Experimental and Theoretical Studies

Analysis of anticancer drugs: A review

Antineoplastic drugs and their analysis: a state of the art review

Contact Info

Product

Resources

About