Stability of flowing open fluidic channels

Tan, Jue Nee; Alan, Tuncay; Neild, Adrian

doi:10.1063/1.4792940

Cited by 11 publications

(13 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[69] Combination of different wettability states on the same surface could lead to new surface properties, such as discontinuous dewetting, [70] which could lead to a number of new surface related applications. Up to now, such patterned surfaces have been used for water collection, [71] patterning of droplets, biomolecules, hydrogels and cells, [72] manipulation of liquid flow, [73,74] control of bioadhesion, [69b,75] miniaturized separation and diagnostics. [76,77] Superhydrophobic-hydrophilic micropatterns are often used for the aforementioned applications.…”

Section: Patterned Slipsmentioning

confidence: 99%

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Ueda

Paulssen

et al. 2018

Adv Funct Materials

192

138

View full text Add to dashboard Cite

Bioinspired lubricant-infused surfaces exhibit various unique properties attributed to their liquid-like and molecularly smooth nature. Excellent liquid repellency and "slippery" properties, self-healing, antiicing, anticorrosion characteristics, enhanced heat transfer, antibiofouling, and cell-repellent properties have been already demonstrated. This progress report highlights some of the recent developments in this rapidly growing area, focusing on properties of lubricant-infused surfaces, and their emerging applications as well as some future challenges.coatings. [8] In order to solve the abovementioned limitations of traditional superhydrophobic and superoleophobic surfaces, Quéré, Aizenberg, and Varanasi proposed bioinspired slippery liquidinfused porous surface (SLIPS) or lubricant-impregnated surfaces combining the mechanical stability of a solid substrate with the liquid-like properties and molecularly smoothness of the lubricant interface. [9a-d] It should be noted that stabilization of a lubricant layer on solid surfaces by forming a thin polymer film that can be swollen in the lubricant was introduced in 1988 by Karakelle and Zdrahala from Bekton, Dickinson and Company.[9e] They also demonstrated excellent long-term stability, liquid repellency, and proposed various medical applications of lubricant-impregnated surfaces. SLIPSs mimic the Nepenthes pitcher plant surface, [10] which is textured and can be lubricated with an aqueous solution. [11] The unique slippery character of the [9a] Nepenthes pitcher plant's surface resulting from water lubrication helps it capture insects sliding into its interior. To mimic the Nepenthes pitcher plant surface, a lubricating hydrophobic liquid can be infused into different hydrophobic porous or rough substrates to form SLIPS. [9] By matching the surface energy of the underlying porous substrate and the hydrophobic lubricant, the liquid can be stabilized on the surface of the substrate to form SLIPS. [9a] Depending on the impregnated lubricant, SLIPSs possess excellent repellency and drop mobility to a broad range of liquids including low surface tension liquids, and complex fluids such as blood or cell medium. [9a] This liquid repellency as well as SLIPS′ self-healing properties are due to the mobility of the lubricant trapped inside the porous surface structures. [12] Lubricant-infused surfaces demonstrated icephobic, stainresistant, biofilm-or cell-repellent or marine antibiofouling properties as well as tolerance to high pressure and transparency. [9,13] All of these unique properties make SLIPS interesting for the development of novel functional materials and various practical applications.The goal of this progress report is not to comprehensively review this broad and dynamic research field but rather highlight selected important aspects that have been less reviewed so far despite their potential. Some important and related papers could not be cited due to the length limitations. We also refer readers to several excellent reviews covering applications of ...

show abstract

Section: Patterned Slipsmentioning

confidence: 99%

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Ueda

Paulssen

et al. 2018

Adv Funct Materials

192

138

View full text Add to dashboard Cite

show abstract

“…Cell culture medium was fed and extracted to the chip by glass needles (Figure B). The use of hydrophilic needles was crucial to maintain the liquid rivulet stable, by preventing the occurrence of the dewetting phenomenon . Other important step on chip optimization it was increasing the paths hydrophilicity by air plasma treatment, using a stencil mask to expose only the channels area to plasma (Figure C).…”

Section: Resultsmentioning

confidence: 99%

Open Fluidics: A Cell Culture Flow System Developed Over Wettability Contrast‐Based Chips

Oliveira

Reis

Mano

2017

Adv Healthcare Materials

View full text Add to dashboard Cite

Biological tissues are recurrently exposed to several dynamic mechanical forces that influence cell behavior. On this work, the focus is on the shear stress forces induced by fluid flow. The study of flow-induced effects on cells leads to important advances in cardiovascular, cancer, stem cell, and bone biology understanding. These studies are performed using cell culture flow (CCF) systems, mainly parallel plate flow chambers (PPFC), and microfluidic systems. Here, it is proposed an original CCF system based on the open fluidics concept. The system is developed using a planar superhydrophobic platform with hydrophilic paths. The paths work as channels to drive cell culture medium flows without using walls for liquid confinement. The liquid streams are controlled just based on the wettability contrast. To validate the concept, the effect of the shear stress stimulus in the osteogenic differentiation of C2C12 myoblast cells is studied. Combining bone morphogenic protein (specifically BMP-2) stimulation with this mechanical stimulus, a synergistic effect is found on osteoblast differentiation. This effect is confirmed by the enhancement of alkaline phosphatase activity, a well-known early marker of osteogenic differentiation. The suggested CCF system combines characteristics and advantages of both the PPFC and microfluidic systems.

show abstract

“…Pressure-driven flows in open channels are accompanied by a varying interface profile along the channel length to compensate for the pressure drop between the inlet and the outlet [75]. The difference between the curvatures at the inlet and the outlet generates the required pressure difference to allow a stable flow, as the Young-Laplace pressure caused by surface tension is curvature dependent.…”

Section: Three-dimensional Steady Flowmentioning

confidence: 99%

“…This ensures that the inlet and outlet ports are connected by the liquid volume and remain so throughout the experiment run time (about 12-15 min). In the absence of this prewetting procedure, the liquid forms a bulge at the inlet which grows radially, rather than advancing along the channel length, eventually spilling over the sides of the open sunken channel, while the outlet takes in air [75]. Further, the volume of water used for prefilling allows other factors to be accounted for, as follows.…”

Section: Setup and Operationmentioning

confidence: 99%

Continuous Focusing of Microparticles in Horizontally Actuated Rectangular Channels

2018

Self Cite

View full text Add to dashboard Cite

We present a device to continuously focus microparticles in a liquid-filled open channel subjected to lateral vibration at frequencies of the order of 10 Hz. The vibration generates a capillary wave at the liquid-air interface. This capillary wave leads to a net motion of microparticles over multiple cycles, causing collection under the displacement nodes of the capillary wave. These accumulated particles are observed as a concentrated stream in the presence of a continuous flow along the open channel, which means that the channel can be designed such that the focused particle stream exits through one outlet, while the filtrate is removed via interspaced outlets on each side of the particle stream. A numerical model is proposed, which superimposes the periodic flow field due to the capillary wave and the inlet-induced transverse flow field between the inlet and the outlet. The model is utilized to predict the smallest distance from the inlet at which the focused stream of particles is obtained, termed here the collection length. In addition, experiments are performed for different channel and inlet sizes, vibration actuation amplitudes, flow rates, and particle sizes. By considering the design factors extracted from the modeling data, we demonstrate that the resulting device is capable of continuous particle collection down to 1 μm diameter, at flow rates of up to 1.2 ml/min.

show abstract

Stability of flowing open fluidic channels

Cited by 11 publications

References 37 publications

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Open Fluidics: A Cell Culture Flow System Developed Over Wettability Contrast‐Based Chips

Continuous Focusing of Microparticles in Horizontally Actuated Rectangular Channels

Contact Info

Product

Resources

About