In the last few years the current density of Bi-2212 wires has been greatly improved by filament densify technologies. One further step toward applications in fusion magnets is to design a high current cable, which must overcome the drawbacks of Bi-2212 wire: brittleness and complex heat treatment process. In this paper, React-and-Wind flat cables are proposed. With react-and-wind technique, a larger choice of jacket and stabilizer materials are available including stainless steel and copper, which are widely used for superconducting cables but are not directly usable for Wind-and-React Bi-2212 cables due to their reaction during heat treatment. Two wires, representing respectively bottom and top performance of state-of-art wires, are considered. Several cable layouts are studied considering dimension, compaction rate and transverse mechanical pressure. Materials for quench protection and jacket materials are also discussed.