Stabilization of enzymes-antioxidants by complex and conjugate formation with block copolymers: Prospects for CNS treatment

Uglanova, S. V.; Попов, М. В.; Kurova, V. S.; Batrakova, Elena V.; Manickam, Devika S.; Kabanov, Alexander V.; Klyachko, N. L.

doi:10.3103/s0027131410030168

Cited by 3 publications

(1 citation statement)

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“…Hemato-encephalic and hemato-ophthalmic barriers protect nervous system tissues from negative effects, but at the same time prevent the action of natural antioxidants. Under prolonged oxidative stress, it is possible that cells accumulate microgly of inflammatory mediators, which in turn contribute to the production of active oxygen forms, providing a cyclical pathological processes [5][6][7][8][9][10]. At the same time, the functioning of protective barriers is impaired, accompanied by the penetration of neurotoxins that contribute to the development of neurodegenerative diseases [11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Study of changes in catalase activity in rat brain under mechanical influence on hemato-ophthalmic barrier

et al. 2020

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Hemato-ophthalmic barrier protects nervous system tissues from adverse factors. Against the background of inflammatory process caused by mechanical trauma of the eye, large molecules are able to penetrate the eyeball. At present, the mechanism of restoring the homeostatic balance of the body under oxidative stress caused by mechanical trauma of the eye is poorly studied. The aim of the study was to study the dynamics of catalase activity in rat brain tissue under oxidative stress caused by mechanical influence on hemato-ophthalmic barrier. Materials and methods: the study was conducted on white male rats of six months of age in the amount of 150 pieces. The activity of catalase in brain tissue was studied before the experiment, as well as on the 1st, 3rd, 5th, 7th and 14th day of the experiment using the standard Korolyuk M.A. method. The obtained digital material was statistically processed by non-parametric statistical analysis. Conclusion: The activity of catalase in the rat brain under oxidative stress caused by mechanical action on the hemato-ophthalmic barrier is most effectively stabilized in the standard therapy of mechanical eye injury with the addition of quercetin in the form of injections.

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