2013
DOI: 10.1016/j.canlet.2013.02.055
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Stabilization of MDA-7/IL-24 for colon cancer therapy

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Cited by 32 publications
(36 citation statements)
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“…In contrast, high concentration of IL-24 strongly induces apoptosis of cancer cells (12,14). IL-24 expression was remarkably correlated with histological differentiation, but inversely correlated with the degree of lymph node involvement in rectal cancer (15), which played an important anti-tumor role for colon cancer therapy (16,17) and even reversed multidrug resistance to chemotherapy in human colorectal cancer cells (18). However, few studies focused on the regulatory activity of IL-24 to immune cell function in colorectal cancers.…”
Section: Introductionmentioning
confidence: 99%
“…In contrast, high concentration of IL-24 strongly induces apoptosis of cancer cells (12,14). IL-24 expression was remarkably correlated with histological differentiation, but inversely correlated with the degree of lymph node involvement in rectal cancer (15), which played an important anti-tumor role for colon cancer therapy (16,17) and even reversed multidrug resistance to chemotherapy in human colorectal cancer cells (18). However, few studies focused on the regulatory activity of IL-24 to immune cell function in colorectal cancers.…”
Section: Introductionmentioning
confidence: 99%
“…14,15 Because recombinant IL-24 shows selective cytotoxicity against cancer cells, clinical trials have investigated the use of IL-24 for the treatment of solid tumors. 16,17 Another example is IL-37, whose intracellular mature form markedly inhibits the migration of multiple types of tumor cells by inhibiting Rac1 activation. 18 Moreover, certain cytokines, such as IL-6, exert tumorpromoting effects.…”
Section: Introductionmentioning
confidence: 99%
“…Low expression of mda/IL-24 has been associated with increased nodal involvement in human breast cancer [44] and reduced survival of colorectal cancer patients [45]. One mechanism by which mda/IL-24 has anticancer effects is by the promotion of cell death, such as the generation of ceramide, the production of reactive oxygen species and increased ER stress and mda-7 gene transfer via vectors such as adenovirus is currently being investigated [46].…”
Section: Expanding DC Populations In Vivo As a Mechanism For Increasementioning
confidence: 99%