2016
DOI: 10.1016/j.msec.2015.11.080
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Stabilization of porous chitosan improves the performance of its association with platelet-rich plasma as a composite scaffold

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Cited by 25 publications
(14 citation statements)
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“…In practice, we envisage that PRP could be easily obtained at bedside and incorporated into the scaffolds intraoperatively using our strategy, prior to implantation. Similar approaches taking advantage of endogenous fibrinogen polymerization in PRP had been attempted with PLA scaffolds for tendon repair (Visser et al, 2010), PLGA (Lei et al, 2009), PCL (Berner et al, 2012), and chitosan (Shimojo et al, 2016) scaffolds for bone regeneration. However, to our knowledge, this work represent the first time that PRP has been incorporated into a proven and commercially available porous regenerative template, the collagen-GAG scaffolds, for skin tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
“…In practice, we envisage that PRP could be easily obtained at bedside and incorporated into the scaffolds intraoperatively using our strategy, prior to implantation. Similar approaches taking advantage of endogenous fibrinogen polymerization in PRP had been attempted with PLA scaffolds for tendon repair (Visser et al, 2010), PLGA (Lei et al, 2009), PCL (Berner et al, 2012), and chitosan (Shimojo et al, 2016) scaffolds for bone regeneration. However, to our knowledge, this work represent the first time that PRP has been incorporated into a proven and commercially available porous regenerative template, the collagen-GAG scaffolds, for skin tissue engineering.…”
Section: Discussionmentioning
confidence: 99%
“…Terminal sterilization of the freeze-dried cakes may be another option when large-scale production becomes required. Other authors have described lyophilized scaffolds composed of chitosan and PRP (Kutlu et al, 2013;Shimojo et al, 2015;Shimojo et al, 2016). These formulations were solid and it is our understanding that they were designed to remain so for implantation.…”
Section: Discussionmentioning
confidence: 99%
“…The weight ( W t ) of sponges was measured and recorded. 18,19 The degradation ratio (DR) of all samples is calculated as follows…”
Section: Physical Property Testmentioning
confidence: 99%