2020
DOI: 10.1038/s41388-020-1183-x
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Stabilization of β-catenin upon B-cell receptor signaling promotes NF-kB target genes transcription in mantle cell lymphoma

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Cited by 17 publications
(10 citation statements)
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“…Similar β-catenin expression patterns were also found in initiating cells of mantle cell lymphoma (MCL) ( Mathur et al., 2015 ). There are several ways of cross talk between Wnt/β-catenin and NF-κB pathways during inflammation ( Aghajanpour-Mir et al., 2016 ) and MCL lymphomagenesis ( Lazarian et al., 2020 ). The NFKB1 gene encodes canonical NF-κB subunit p105, which is processed by the proteasome into p50 to form a p65/p50 heterodimer transcription factor, and is considered a regulator of innate immunity.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Similar β-catenin expression patterns were also found in initiating cells of mantle cell lymphoma (MCL) ( Mathur et al., 2015 ). There are several ways of cross talk between Wnt/β-catenin and NF-κB pathways during inflammation ( Aghajanpour-Mir et al., 2016 ) and MCL lymphomagenesis ( Lazarian et al., 2020 ). The NFKB1 gene encodes canonical NF-κB subunit p105, which is processed by the proteasome into p50 to form a p65/p50 heterodimer transcription factor, and is considered a regulator of innate immunity.…”
Section: Discussionmentioning
confidence: 99%
“…The NFKB1 gene encodes canonical NF-κB subunit p105, which is processed by the proteasome into p50 to form a p65/p50 heterodimer transcription factor, and is considered a regulator of innate immunity. Canonical NF-κB signals are connected to pathological pathways in low-grade Mucosa-associated lymphoid tissue (MALT) lymphoma ( Hamoudi et al., 2010 ; Nagel et al., 2014 ), high-grade MCL ( Aghajanpour-Mir et al., 2016 ; Lazarian et al., 2020 ), as well as DLBCL of ABC type ( Compagno et al., 2009 ; Davis et al., 2001 ; Nagel et al., 2014 ). AR (androgen receptor) interplay with NF-κB has been linked in prostate cancer ( Malinen et al., 2017 ; Zhang et al., 2009 ).…”
Section: Discussionmentioning
confidence: 99%
“… 34 , 35 The dysregulation of the Wnt/β-catenin signaling pathway modulates crucial cancer biological processes, such as proliferation, metastasis, metabolism, and cancer cells’ stemness. 36 - 38 As is well known, Wnt/β-catenin signaling pathway is thought to act key influences on LUAD. 39 For instance, it has demonstrated that Wnt/β-catenin signaling pathway could regulate the LUAD cell proliferation, migration and apoptosis.…”
Section: Discussionmentioning
confidence: 99%
“…29,30 There are several studies of this polymorphism in cancer and other diseases. [31][32][33] These studies found that NFκB-94 ins/del polymorphism may influence the risk of cancer in Asian population. The variant allele of NFκB-94 ins/del ATTG (rs28362491) polymorphism was shown to be associated with higher risk of sporadic CRC in Malaysian population, and functional NFκB-94 ins/del ATTG polymorphism is associated with CSCC.…”
mentioning
confidence: 91%