Stabilizing Incidence of Hepatitis C Virus Infection Among Men Who Have Sex With Men in Amsterdam

Vanhommerig, Joost W.; Stolte, Ineke G.; Lambers, Femke A.E.; Geskus, Ronald B.; Laar, T.J.W. van de; Bruisten, Sylvia M.; Schinkel, Janke; Prins, Maria

doi:10.1097/qai.0000000000000208

Cited by 42 publications

(62 citation statements)

References 19 publications

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“…[34][35][36][37][38] Similar to crosssectional studies, CAI 32,37,39 and a history of syphilis 32,37 were also reported as risk factors for incident HCV infection. However, the association with CAI was only significant in non-IDU in one Swiss clinic-based study of 1543 HIV-positive men.…”

Section: Other Risk Factors In Addition To Injecting Drug Usementioning

confidence: 63%

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2017

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Abstract.A systematic review was performed on the evidence of sexual transmission of hepatitis C virus (HCV) in gay and bisexual men (GBM). Studies conducted in industrialised countries and published in English from 2000 to 2015 with data on HCV in GBM were included. Pooled estimates of prevalence and incidence of HCV infection were stratified by study settings and participants' HIV status using random effect models. Case-series reports were summarised descriptively. Of the 38 cross-sectional studies, the pooled HCV prevalence was substantially higher in HIV-positive men (8.3%, 95% CI: 6.7-9.9) than in HIV-negative men (1.5%, 95% CI 0.8-2.1), and higher in those who reported injecting drug use (34.8%, 95% CI 26.9-42.7) than in those who did not (3.5%, 95% CI 2.4-4.5). Of the 16 longitudinal studies, the pooled HCV incidence was markedly higher in clinic-based (7.0 per 1000 person-years, 95% CI 4.6-9.5) than in community-based (1.4 per 1000 person-years, 95% CI 0.7-2.1) studies, and in HIV-positive men (6.4 per 1000 person-years, 95% CI 4.6-8.1) than in HIV-negative men (0.4 per 1000 person-years, 95% CI 0-0.9). Since the early 2000s, 15 case-series reports increasingly pointed to the importance of sexual transmission of HCV in mainly HIV-positive men. Injecting drug use remained the major transmission route of HCV in GBM. Receptive condomless intercourse and concurrent ulcerative sexually transmissible infections are likely drivers that facilitated HCV sexual transmission in HIV-positive men. HCV incidence remains very low in HIV-negative GBM.

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Section: Other Risk Factors In Addition To Injecting Drug Usementioning

confidence: 63%

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2017

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“…"chem-sex" party settings) (167,168). Whilst permucosal transmission does account for acquisition in HIV-positive men, data are lacking to support significant permucosal transmission in HIV-negative MSM (169,170).…”

Section: Hepatitis Cmentioning

confidence: 99%

2016 United Kingdom national guideline on the sexual health care of men who have sex with men

et al. 2018

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This guideline is intended for use in UK Genitourinary medicine clinics and sexual health services but is likely to be of relevance in all sexual health settings, including general practice and Contraception and Sexual Health (CASH) services, where men who have sex with men (MSM) seek sexual health care or where addressing the sexual health needs of MSM may have public health benefits. For the purposes of this document, MSM includes all gay, bisexual and all other males who have sex with other males and both cis and trans men. This document does not provide guidance on the treatment of particular conditions where this is covered in other British Association for Sexual Health and HIV (BASHH) Guidelines but outlines best practice in multiple aspects of the sexual health care of MSM. Where prevention of sexually transmitted infections including HIV can be addressed as an integral part of clinical care, this is consistent with the concept of combination prevention and is included. The document is designed primarily to provide guidance on the direct clinical care of MSM but also makes reference to the design and delivery of services with the aim of supporting clinicians and commissioners in providing effective services. Methodology This document was produced in accordance with the guidance set out in the BASHH CEG’s document ‘Framework for guideline development and assessment’ published in 2010 at http://www.bashh.org/guidelines and with reference to the Agree II instrument. Following the production of the updated framework in April 2015, the GRADE system for assessing evidence was adopted and the draft recommendations were regraded. Search strategy (see also Appendix 1) Ovid Medline 1946 to December 2014, Medline daily update, Embase 1974 to December 2014, Pubmed NeLH Guidelines Database, Cochrane library from 2000 to December 2014. Search language English only. The search for Section 3 was conducted on PubMed to December 2014. Priority was given to peer-reviewed papers published in scientific journals, although for many issues evidence includes conference abstracts listed on the Embase database. In addition, for ‘Identification of problematic recreational drug and alcohol use’ section and ‘Sexual problems and dysfunctions in MSM’ section, searches included PsycINFO. Methods Article titles and abstracts were reviewed and if relevant the full text article was obtained. Priority was given to randomised controlled trial and systematic review evidence, and recommendations made and graded on the basis of best available evidence. Piloting and feedback The first draft of the guideline was circulated to the writing group and to a small group of relevant experts, third sector partners and patient representatives who were invited to comment on the whole document and specifically on particular sections. The revised draft was reviewed by the CEG and then reviewed by the BASHH patient/public panel and posted on the BASHH website for public consultation. The final draft was piloted before publication. Guideline update The guidelines will be reviewed and revised in five years’ time, 2022.

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“…136 LGV or in situations of traumatic anal sex, fisting and sharing of sex toys. [138][139][140] . Since September 1991 all donated blood in the UK has been screened for HCV.…”

Section: Screening and Primary Preventionmentioning

confidence: 98%

“…In patients with chronic infection, sexual transmission should be discussed. It seems likely that if condoms are used consistently then sexual transmission will be avoided, but given the very low rates of transmission outside of HIV co-infection[136][137][138][139][140][141][142] (see above), monogamous partners may choose not to use them. Sexual contacts with HIV should be advised of the risk of sexual transmission, with regular testing and condom use encouraged (1D) [136][137][138][139][140][141][142].…”

mentioning

confidence: 96%

United Kingdom National Guideline on the Management of the viral hepatitides A, B and C 2015

et al. 2016

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Stabilizing Incidence of Hepatitis C Virus Infection Among Men Who Have Sex With Men in Amsterdam

Cited by 42 publications

References 19 publications

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

Sexual transmission of hepatitis C virus among gay and bisexual men: a systematic review

2016 United Kingdom national guideline on the sexual health care of men who have sex with men

United Kingdom National Guideline on the Management of the viral hepatitides A, B and C 2015

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