2013
DOI: 10.1021/ic400384f
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Stable and Highly Fluorescent Europium(III) Chelates for Time-Resolved Immunoassays

Abstract: Derivatives of 4-[2-(4-isothiocyanatophenyl)ethynyl]-2,6,-bis{[N,N-bis(carboxymethyl)-amino]methyl}pyridine europium(III) (1) bearing one (6) or two (7) additional iminodiacetate coordinating arms have been synthesized. 6 and 7 were significantly more stable than 1 as evidenced by competition experiments with ethylenediaminetetraacetic acid (EDTA) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA). While the luminescence quantum yield of 1 remained modest, the other two complexes displayed sub… Show more

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Cited by 34 publications
(31 citation statements)
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“…Alternative equations for q (H 2 O) have been derived from experimental data in the literature by considering the contributions of different oscillators or the quenching effect of unbound water molecules,42, 43 although we reference this simple form of the Horrocks equation. By applying the equation presented by Beeby et al.,43 the number of coordinated water molecules would be 2.2 for 7‐D ,44 3.3 for 6‐D , and 4.2 for 5‐D .…”
Section: Resultsmentioning
confidence: 99%
“…Alternative equations for q (H 2 O) have been derived from experimental data in the literature by considering the contributions of different oscillators or the quenching effect of unbound water molecules,42, 43 although we reference this simple form of the Horrocks equation. By applying the equation presented by Beeby et al.,43 the number of coordinated water molecules would be 2.2 for 7‐D ,44 3.3 for 6‐D , and 4.2 for 5‐D .…”
Section: Resultsmentioning
confidence: 99%
“…Inhibitory peptides, CU-128 (FARKTELKLAF, Raf-S) and CU-129 (ARRFFLDIAD, NF1-S), were purchased from ChinaPeptides Co., Ltd. (Shanghai, China). 16 18,19 PCR reagents and Fab fragment cloning reaction components including enzymes were purchased from Thermo Scientific, Fermentas (Vilnius, Lithuania) and www.Biomers.net GmbH (Ulm, Germany). Antibody selection particles, SA-or avidincoated magnetic C1-MyOne nanoparticles were from Dynal (Oslo, Norway), and self-coated SA-polystyrene particles were from Thermo Scientific, Seradyn (Indianapolis, IN, U.S.A.).…”
Section: ■ Materials and Methodsmentioning
confidence: 99%
“…First, the seven-dentate europium chelate Eu7D provides stable luminescence intensities and lifetimes of the 615 nm peak free from common interferences 26 and is stable in an acidic environment until a pH of 3. 27 Its quantum yield of 0.06 is comparatively high for europium complexes in aqueous solution. S2, ESI †).…”
mentioning
confidence: 99%