Stable Gastric Pentadecapeptide BPC 157 and Wound Healing

Abstract

Significance: The antiulcer peptide, stable gastric pentadecapeptide BPC 157 (previously employed in ulcerative colitis and multiple sclerosis trials, no reported toxicity (LD1 not achieved)), is reviewed, focusing on the particular skin wound therapy, incisional/excisional wound, deep burns, diabetic ulcers, and alkali burns, which may be generalized to the other tissues healing.Recent Advances: BPC 157 has practical applicability (given alone, with the same dose range, and same equipotent routes of application, regardless the injury tested).Critical Issues: By simultaneously curing cutaneous and other tissue wounds (colocutaneous, gastrocutaneous, esophagocutaneous, duodenocutaneous, vesicovaginal, and rectovaginal) in rats, the potency of BPC 157 is evident. Healing of the wounds is accomplished by resolution of vessel constriction, the primary platelet plug, the fibrin mesh which acts to stabilize the platelet plug, and resolution of the clot. Thereby, BPC 157 is effective in wound healing much like it is effective in counteracting bleeding disorders, produced by amputation, and/or anticoagulants application. Likewise, BPC 157 may prevent and/or attenuate or eliminate, thus, counteract both arterial and venous thrombosis. Then, confronted with obstructed vessels, there is circumvention of the occlusion, which may be the particular action of BPC 157 in ischemia/reperfusion.Future Directions: BPC 157 rapidly increases various genes expression in rat excision skin wound. This would define the healing in the other tissues, that is, gastrointestinal tract, tendon, ligament, muscle, bone, nerve, spinal cord, cornea (maintained transparency), and blood vessels, seen with BPC 157 therapy.

Stable Gastric Pentadecapeptide BPC 157 Heals Established Vesicovaginal Fistula and Counteracts Stone Formation in Rats

“…Of note, this was not especially investigated in the present study. However, considering the proposed essential role of the ischemia in the falling course of the vesicovaginal fistulas [14], it may be stated that BPC 157 exhibits a particular effect on blood vessels [1][2][3][4], and may rapidly activate collateral pathways to circumvent major vessel occlusion, and reestablish blood flow and compensate otherwise imminent ischemic consequences. There is rapid counteracting effect noted in various severe permanent occlusion of major vessels-induced occlusive syndromes [47][48][49][50][51][52].…”

“…With the stable gastric pentadecapeptide BPC 157 therapy (for review, see, i.e., [1][2][3][4]), known to heal various both external [5][6][7][8] and internal [9,10] rat fistulas, we attempt to approach vesicovaginal fistula, continuous urine leaking through vagina, and bladder stones [11][12][13][14], as well as a possible therapy solution. Patients with a vesicovaginal fistula, the most common form of genitourinary fistula [11,14], typically present with continuous vaginal urine drainage [14], and smell of urine [15], and the degree of urinary incontinence is typically proportional to the size of the fistula tract [16], and likely presentation of the bladder stone that may further erode fistula as well.…”

“…Of note, as an especial point, the proposed BPC 157 effectiveness in the resistant vesicovaginal fistulas goes with its wound healing potential, recently reviewed (i.e., skin, muscle, tendon, ligament, bone; ulcers in the entire gastrointestinal tract; corneal ulcer; lethal dose (LD1) is not achieved) [4,17], and molecular pathways implicated in the healing [18][19][20][21][22][23][24][25][26][27], in the fistulas curing in particular [3]. Thereby, there is the assumption that the healing of the various wounds is equally essential for both gastrointestinal fistulas and urogenital fistulas healing [3,4].…”

“…Of note, as an especial point, the proposed BPC 157 effectiveness in the resistant vesicovaginal fistulas goes with its wound healing potential, recently reviewed (i.e., skin, muscle, tendon, ligament, bone; ulcers in the entire gastrointestinal tract; corneal ulcer; lethal dose (LD1) is not achieved) [4,17], and molecular pathways implicated in the healing [18][19][20][21][22][23][24][25][26][27], in the fistulas curing in particular [3]. Thereby, there is the assumption that the healing of the various wounds is equally essential for both gastrointestinal fistulas and urogenital fistulas healing [3,4]. Documented consistent healing of the various gastrointestinal fistulas, external (esophagocutaneous, gastrocutaneous, duodenocutaneous, and colocutaneous) [5][6][7][8] and internal (colovesical, rectovaginal) [9,10], was ascribed to its original healing capacity as a peptide native and stable in human gastric juice, and its possible role as novel mediator of Robert's cytoprotection maintaining gastrointestinal mucosal integrity [3], as it is effective in the whole gastrointestinal tract and used in ulcerative colitis clinical trials [1][2][3][4].…”

“…Thereby, there is the assumption that the healing of the various wounds is equally essential for both gastrointestinal fistulas and urogenital fistulas healing [3,4]. Documented consistent healing of the various gastrointestinal fistulas, external (esophagocutaneous, gastrocutaneous, duodenocutaneous, and colocutaneous) [5][6][7][8] and internal (colovesical, rectovaginal) [9,10], was ascribed to its original healing capacity as a peptide native and stable in human gastric juice, and its possible role as novel mediator of Robert's cytoprotection maintaining gastrointestinal mucosal integrity [3], as it is effective in the whole gastrointestinal tract and used in ulcerative colitis clinical trials [1][2][3][4]. Taking fistulas as a pathological connection, and BPC 157 to reestablish original organ function [3], this particular rescue is verified with the beneficial effects in the rats with the various gastrointestinal anastomoses (i.e., esophagogastric [28], jejunoileal [29,30], colo-colonic [31], ileoileal [32], esophagojejunal [33], esophagoduodenal [34], and gastrojejunal [35]) as well as vessel [36] and nerve [37] anastomoses.…”