Stable SERS substrate based on highly reflective metal liquid-like films wrapped hydrogels for direct determination of small molecules in a high protein matrix

Huo, Chengcheng; Han, Wanying; Tang, Wei; Duan, Xinrui

doi:10.1016/j.talanta.2021.122678

Cited by 11 publications

(2 citation statements)

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“…The poly(acrylic acid) was used as a surface-capping agent that binds on the surface of Ag nanostructures to prevent their uncontrolled aggregation. It is worth noting that the polymeric modifiers also acted as a steric barrier, hindering access of the analyte to the SERS-active substrate, thus negatively impacting the sensitivity of the SERS measurement [54][55][56]. Additionally, the polymeric modifiers on the surface of metal nanostructures generate obvious background signals in the Raman spectrum.…”

Section: Characterization Of Ag Nanoparticlesmentioning

confidence: 99%

“…Additionally, the polymeric modifiers on the surface of metal nanostructures generate obvious background signals in the Raman spectrum. The background depends dramatically on carbon chain length, influencing the specificity of SERS measurement [55,57,58]. Thus, the selectivity and amount of capping agents have important roles in the SERS analysis.…”

Section: Characterization Of Ag Nanoparticlesmentioning

confidence: 99%

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Versatile Silver Nanoparticles-Based SERS Substrate with High Sensitivity and Stability

et al. 2021

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Surface-enhanced Raman scattering has developed into a mature analytical technique useful in various applications; however, the reproducible fabrication of a portable SERS substrate with high sensitivity and good uniformity is still an ongoing pursuit. Reported herein is a rapid fabrication method of an inexpensive SERS substrate that enables sub-nanomolar detection of molecular analytes. The SERS substrate is obtained by application of silver nanoparticles (Ag NPs)-based ink in precisely design patterns with the aid of an in-house assembled printer equipped with a user-fillable pen. Finite-difference time-domain (FDTD) simulations show a 155-times Ag NP electric field enhancement for Ag nanoparticle pairs with particle spacing of 2 nm. By comparing the SERS performance of SERS substrate made with different support matrices and fabrication methods, the PET-printed substrate shows optimal performance, with an estimated sensitivity enhancement factor of 107. The quantitative analysis of rhodamine 6G absorbed on optimized SERS substrate exhibits a good linear relationship, with a correlation coefficient (R2) of 0.9998, between the SERS intensity at 610 cm−1 and the concentration in the range of 0.1 nM—1μM. The practical low limit detection of R6G is 10 pM. The optimized SERS substrates show good stability (at least one month) and have been effectively tested in the detection of cancer drugs, including doxorubicin and metvan.

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Section: Characterization Of Ag Nanoparticlesmentioning

confidence: 99%

Section: Characterization Of Ag Nanoparticlesmentioning

confidence: 99%