Stage at Diagnosis of Cancer Varies With the Age of the Patient

Goodwin, James S.; Samet, Jonathan M.; Key, Charles R.; Humble, Charles G.; Kutvirt, Daniel M.; Hunt, C R

doi:10.1111/j.1532-5415.1986.tb06335.x

Cited by 150 publications

(48 citation statements)

References 18 publications

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“…We observed that patients' characteristics associated with delay comprise older age, history of benign mastopathy, obesity, not Older women are more prone to procrastinate early detection of breast cancer resulting in more advanced disease and fewer asymptomatic cases (Holmes and Hearne, 1981;Goodwin et al, 1986;Lickley, 1997). Similar findings have been reported from various countries (Polednak, 1986;Yancik et al, 1989;Coates et al, 1992;Afzelius et al, 1994;Fowble et al, 1994;Ramirez et al, 1999).…”

Section: Discussionmentioning

confidence: 89%

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Patient delay and stage of diagnosis among breast cancer patients in Germany – a population based study

et al. 2002

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Early diagnosis is a tenet in oncology and should enable early treatment with the expectation of improved outcome. Extent and determinants of patient delay of diagnosis in breast cancer patients and its impact on stage of disease were examined in a population based study among female breast cancer patients in Germany. Two hundred and eighty-seven women, aged 18 to 80 years with newly diagnosed invasive symptomatic breast cancer, were interviewed with respect to the diagnostic process. Patient delay was defined as time from onset of first symptoms to first consultation of a doctor. Median patient delay was 16 days among symptomatic patients. Eighteen per cent of all breast cancer patients waited longer than 3 months before consulting a physician. Long patient delay was associated with old age, history of a benign mastopathy, obesity, and indices of health behaviour such as not knowing a gynaecologist for out-patient care and non-participation in general health screening examinations. A strong association between patient delay and stage at diagnosis was observed for poorly differentiated tumours. These results suggest that at risk groups for delaying consultation can be identified and that a substantial proportion of late stage diagnoses of poorly differentiated breast cancer cases could be avoided if all patients with breast cancer symptoms would present to a doctor within 1 month.

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Section: Discussionmentioning

confidence: 89%

“…Fatalism, e.g. a sense that one has lived long enough, might be another reason for the higher proportion of patient delay among older breast cancer patients (Facione, 1993;Goodwin et al, 1986;Lierman, 1988). …”

Section: Discussionmentioning

confidence: 99%

Patient delay and stage of diagnosis among breast cancer patients in Germany – a population based study

et al. 2002

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“…28 In another analysis, the percentage of patients with local stage disease was higher among those aged 75 to 84 years compared with those aged 55 years (39% vs 26%). 29 This was associated with a decline in the rate of advanced disease in the older patients (41% vs 46%).…”

Section: Discussionmentioning

confidence: 99%

Effect of age on the efficacy of adjuvant chemotherapy for resected non–small cell lung cancer

Ganti¹,

Williams

Gajra

et al. 2015

Cancer

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BACKGROUND: Adjuvant chemotherapy after surgical resection improves outcomes for patients with early-stage non-small cell lung cancer (NSCLC). To the authors' knowledge, there are no published prospective trials to date of adjuvant chemotherapy after surgical resection administered exclusively in older patients. In the current study, the authors sought to evaluate the efficacy of adjuvant chemotherapy in older patients in a Veterans Health Administration cohort. METHODS: Patients who underwent surgical resection for American Joint Committee on Cancer stages IB to III NSCLC between 2001 and 2011 were analyzed. Data regarding patient demographics and comorbidities, tumor characteristics, and primary treatment were collected. Patients were divided into 2 groups based on age at diagnosis: those aged <70 years and those aged 70 years. The primary exposure was use of adjuvant chemotherapy. A Cox proportional hazards model was used to estimate the significance of patient characteristics. Survival curves were estimated using the Kaplan-Meier method and group comparisons were performed using the log-rank test. RESULTS: The analysis included 7593 patients who underwent surgical resection for stage IB to stage III NSCLC. Among these, 2897 patients (38%) were aged 70 years. The percentage of older patients who received adjuvant chemotherapy was approximately one-half that of younger patients who did so (15.3% vs 31.6%; P<.0001). Carboplatin-based doublets were used most often in all patients (64.6%). Both younger patients (hazard ratio, 0.79; 95% confidence interval, 0.72-0.86) and older patients (hazard ratio, 0.81; 95% confidence interval, 0.71-0.92) were found to have a lower risk of death with receipt of adjuvant chemotherapy. CONCLUSIONS: Older patients derive a similar magnitude of benefit from adjuvant chemotherapy as younger patients and therefore adjuvant chemotherapy should not be withheld based on age alone. Cancer 2015;121:2578-85. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.

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“…Differences Finally, both delay and extent of disease at diagnosis may be related to age (Goodwin et al, 1986) (Hisserich et al, 1975;Mack, 1977). The method of case identification has been described elsewhere (Mack, 1977 (Breslow & Day, 1980).…”

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confidence: 99%

Stage and delay in breast cancer diagnosis by race, socioeconomic status, age and year

Richardson

Langholz²,

Bernstein³

et al. 1992

Br J Cancer

170

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Stage at Diagnosis of Cancer Varies With the Age of the Patient

Cited by 150 publications

References 18 publications

Patient delay and stage of diagnosis among breast cancer patients in Germany – a population based study

Patient delay and stage of diagnosis among breast cancer patients in Germany – a population based study

Effect of age on the efficacy of adjuvant chemotherapy for resected non–small cell lung cancer

Stage and delay in breast cancer diagnosis by race, socioeconomic status, age and year

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