Stage-dependent reactivity of thymocytes to self-peptide–MHC complexes

Abstract

antigen recognition degeneracy ͉ development ͉ lineage ͉ positive and negative selection ͉ T cell antigen receptor

A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling

“…59 The presence of an ␣␤TCR is associated with impaired transition from DN to DP thymocytes. 60,61 Thus, the alterations in T-cell development at the DN/DP stages common to all these backgrounds may account for the acceleration of Stat5b-mediated lymphomagenesis in these mice.…”

Implication of the CD47 pathway in autoimmune diabetes

“…6a). We performed additional phenotypic characterization and demonstrate that 3A9 TCR transgenic DN T cells express many naïve T cell markers such as CD3, CD62L and CD45RB at levels comparable to CD4 T cells from TCR transgenic mice and low levels of CD5 [46,52] (Fig. 6b).…”

Peptide-Specific, TCR-α–Driven, Coreceptor-Independent Negative Selection in TCR α-Chain Transgenic Mice

“…The impact of MHC-peptide recognition on thymocytes prematurely expressing TCR has been investigated in the MHC class I-restricted, 2C TCR Tg strain (17). Somewhat surprisingly, the K b class I molecule, which directs conventional positive selection of DP to SP8 thymocytes, also mediates the negative selection of a proportion of DN 2C + thymocytes.…”

“…In the absence of K b expression in TAP 2/2 mice, the A b class II molecule acts to promote the selection of DP 2C thymocytes. Immature thymocytes are thus uniquely MHCpeptide sensitive, as those K b /self-peptide complexes mediating positive selection of DP thymocytes can also deliver a coreceptorindependent, negatively selecting signal at the DN stage (17).…”