Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol

Abstract

After the age of 55 almost every third woman suffers from conditions of the incapability to retain urine when the intra-abdominal pressure is raised by different causes. So called stress incontinence. It’ s caused by a predisposition in the family, weakness of the tissue, physical strain, deficiency in the metabolism, especially an increasing local estrogen deficiency and a local and systemic vitamin D deficiency. Patients: We evaluated the data of 60 meno- and postmenopausal female patients with a stress incontinence (SIC). All had a SIC in spite of a former local estriol treatment with a treatment of OeKolp® forte (= 0.5 mg estriol/ov), 3 times a week, for 6 weeks and in spite of a regular pelvic floor exercise for 6 weeks in the morning and in the evening, according to the protocol. Thirty were in stage I SIC and 30 were in stage II SIC. Method: We evaluated vitamin-D-levels in serum of our 60 postmenopausal women. Only 20% of this group had good vitamin D-levels. The medical intervention combined estriol (0.5 mg) together with high dosed vitamin D (12.500 I.U.) locally 3 times a week for a period of 6 weeks. The patients also had the instruction to continue their daily exercises in pelvic floor (morning and evening, due to their protocol). After six weeks of treatment the vitamin D level in serum was defined and correlated to the patients condition (symptomatic of stress incontinence, protocol of micturitions, Pad-test). Results: About one-third of women from our test assigned to be now capable of retaining urine. More than one-third of our patients cleared a profit of treatment. They reported mimimum regression about 25% of volume of incontinence. Therefore more than 2-third of our women being incapable of retaining urine improved their body conditions by using a combination of locally administered etriol and high dosed vitamin D. Conclusion: Stress incontinence (being incapable of retaining urine when the intra-abdominal pressure arises) in lower and middle grade, improves their body conditions under a combination of local administered estriol and vitamin D. This small study is not representative. We need much bigger studies with much more dates and with a follow up.

Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial

“…It has also been proposed to lessen or prevent female reproductive disorders [ 6 – 12 ]. Vitamin D3 can be absorbed when applied vaginally, as its receptors are located in the basal and parabasal cellular layers of the vaginal tissue [ 13 ]. Physiologically, vaginal epithelial cell proliferation might be regulated by vitamin D [ 8 , 9 ].…”

Investigating the effect of vitamin D vaginal suppository on sexual function among postmenopausal women: study protocol for a randomized controlled trial

“…Approximately one-third of postmenopausal women have reported painful intercourse (dyspareunia), lack of moisture, and lubrication [11]. Dyspareunia, vaginal dryness, and lack of lubrication are due to vulvovaginal atrophy [9,10].…”

“…Vulvovaginal atrophy lead to vaginal dryness, irritation, soreness, and consequently dyspareunia [9,10]. Approximately one-third of postmenopausal women report painful intercourse (dyspareunia), lack of moisture, and decreased lubrication [11]. Common symptoms of atrophy include vaginal dryness, burning, post-coital bleeding, and pain [12].…”

“…Vitamin D3 can be absorbed in the vagina by applying a vaginal suppository [11]. The results of a clinical trial study by Rad et al (2014) on postmenopausal women in Ahwaz (Iran) showed that vitamin D suppositories could experimentally (according to the results of the participants' Pap smear) improve dryness and cell proliferation of the vaginal mucosa among postmenopausal women [24].…”

Long-Term Effectiveness and Complications of Mid-Urethral Slings: Clinical Case

“…Based on the amount of urine in the pad, the severity can be measured in 3 grades: 1 or mild, when the amount of urine is less than 10 grams per day, 2 or moderate when there is between 11 and 50 grams of urine found. When the patient involuntarily urinates more than 50 grams per day it is recognised as 3 grade or severe urinary incontinence (6). There are more methods, by which severity of urinary incontinence can be measured.…”