Stage IB cervical carcinoma and pregnancy: Report of 49 cases

Nisker, Jeffrey A.; Shubat, Michael

doi:10.1016/0002-9378(83)90492-1

Cited by 72 publications

(25 citation statements)

References 5 publications

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“…Prognosis of early cervical cancer seems to be similar to non-pregnant women [6,7]. However, rapid cancer progression is also reported [1,8,9]. Only operative (laparoscopic) lymphadenectomy provides exact knowledge of lymph node involvement as the most important prognostic factor, but is a surgical challenge in pregnant patients [10,11].…”

Section: Introductionmentioning

confidence: 99%

Cisplatin Application in Pregnancy: First in vivo Analysis of 7 Patients

Marnitz¹,

Köhler²,

Oppelt

et al. 2010

Oncology

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Cervical cancer in pregnancy is an oncologic challenge. Empirical cisplatin is recommended to prevent cancer progression until fetal maturity. Seven patients with cervical cancer in the second trimester decided to delay delivery together with neoadjuvant chemotherapy. After 2–4 cycles, caesarean section and radical hysterectomy were performed above 32 weeks of gestation. Synchronous samples from maternal blood, umbilical cord blood and amniotic fluid were taken. All patients delivered healthy babies. Cisplatin concentrations in umbilical cord and amniotic fluid were 31–65 and 13–42% of the maternal blood, respectively. This is the first series on in vivo cisplatin concentration in the fetomaternal compartment.

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Section: Introductionmentioning

confidence: 99%

Cisplatin Application in Pregnancy: First in vivo Analysis of 7 Patients

Marnitz¹,

Köhler²,

Oppelt

et al. 2010

Oncology

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“…It is reported that the serious complication rate in CRH is lower than that of radiation therapy (6.7 vs. 28.8%) [6]. However, compared to RH for nonpregnant women, heavier blood loss during surgery (1750 vs. 777 ml) and a higher transfusion rate (75 vs. 54%) were also reported [7].…”

Section: Discussionmentioning

confidence: 99%

“…CRH has the benefit of incurring fewer complications than radiation therapy [6], but heavy blood loss during CRH is a major surgical complication [7,8].…”

Section: Introductionmentioning

confidence: 99%

Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy

2010

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“…Retrospective studies with small patient numbers showed that only 5% (4/76) of pregnant patients died of cervical cancer after postponing therapy for an average of 16 weeks, indicating the satisfactory safety profile of postponed therapy, especially for early-stage tumor (Lee et al, 1981;Takushi et al, 2002;Hunter et al, 2008). Postponed therapy for stage IB1 cancer patients did not promote tumor recurrence in cases with no pelvic lymph node metastasis visible by laparoscopy (Nisker and Shubat, 1983;Greer et al, 1989;Alouini et al, 2008;Lee et al, 2008). Furthermore, it has been reported that tumor growth can be well controlled by neoadjuvant chemotherapy with little adverse effects on pregnancy (Marana et al, 2001;Caluwaerts et al, 2006;Boyd et al, 2009;Chun et al, 2010;Favero et al, 2010;Rabaiotti et al, 2010;Smyth et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution

Zhang

Yong-liang

Yang

2015

J. Zhejiang Univ. Sci. B

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Abstract:This study was designed to investigate the therapeutic approaches and prognosis for cervical cancer associated with pregnancy. Clinical information, therapeutic strategies, and follow-up results of 20 patients with cervical cancer associated with pregnancy from Jan. 2000 to June 2009 in the Zhejiang Cancer Hospital were retrospectively analyzed. The International Federation of Gynecology and Obstetrics (FIGO) stages were: in situ (n=1), stage IA1 (n=1), stage IB1 (n=5), stage IB2 (n=1), stage IIA (n=8), stage IIB (n=3), and stage IIIB (n=1). Eight patients were in the first trimester of pregnancy, four in the second, two in the third, and six at postpartum when diagnosed. The therapeutic strategies were either single or combined modalities, including surgery, radiotherapy, and chemotherapy. Fourteen patients survived, five patients died (four of remote metastasis and one of uremia), and one patient was lost to follow-up. One newborn from a patient at stage IIA carcinoma in the third trimester with postponed therapy six weeks after diagnosis survived. Retarded fetal growth was observed in one patient receiving neoadjuvant chemotherapy and cesarean section. Out of the six postpartum patients, three underwent cesarean section and survived, whereas only one out of the three who underwent vaginal delivery survived. The remaining two died of remote metastasis. Therefore, personalized treatment is necessary for cervical cancer associated with pregnancy. Cervical cancer patients in the third trimester of pregnancy can continue the pregnancy for a short period of time. There may be potential risk for the fetus by chemotherapy during pregnancy. Cesarean section is the preferred mode of delivery for pregnant cervical cancer patients.

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Stage IB cervical carcinoma and pregnancy: Report of 49 cases

Cited by 72 publications

References 5 publications

Cisplatin Application in Pregnancy: First in vivo Analysis of 7 Patients

Cisplatin Application in Pregnancy: First in vivo Analysis of 7 Patients

Amputation of uterine corpus as the intraoperative modification during cesarean radical hysterectomy for invasive cervical cancer during pregnancy

Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution

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