Stage-related decrease in natural killer cell activity in untreated patients with mycosis fungoides

Levy, Salomon Mony; Tempé, Jean-Louis; Caussade, P.; Aleksijevic, A.; Grosshans, É; Mayer, S.; Lang, J. M.

doi:10.1007/bf00205749

Cited by 17 publications

(4 citation statements)

References 6 publications

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“…High levels of NKCC covary with a better prognosis and overall survival in many different cancers33–35. Impaired NKCC has been found to correlate with stage of disease36, and NK cell infiltration into primary tumors is associated with less lymphatic invasion, fewer metastases, and better survival37.…”

Section: Discussionmentioning

confidence: 99%

Biobehavioral, Immune, and Health Benefits following Recurrence for Psychological Intervention Participants

Andersen

Thornton

Shapiro

et al. 2010

Clinical Cancer Research

146

107

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Purpose: A clinical trial was designed to test the hypothesis that a psychological intervention could reduce the risk of cancer recurrence. Newly diagnosed regional breast cancer patients (n = 227) were randomized to the intervention-with-assessment or the assessment-only arm. The intervention had positive psychological, social, immune, and health benefits, and after a median of 11 years the intervention arm was found to have reduced the risk of recurrence (hazard ratio, 0.55; P = 0.034). In follow-up, we hypothesized that the intervention arm might also show longer survival after recurrence. If observed, we then would examine potential biobehavioral mechanisms.Experimental Design: All patients were followed; 62 recurred. Survival analyses included all 62. Upon recurrence diagnosis, those available for further biobehavioral study were accrued (n = 41, 23 intervention and 18 assessment). For those 41, psychological, social, adherence, health, and immune (natural killer cell cytotoxicity, T-cell proliferation) data were collected at recurrence diagnosis and 4, 8, and 12 months later.Results: Intent-to-treat analysis revealed reduced risk of death following recurrence for the intervention arm (hazard ratio, 0.41; P = 0.014). Mixed-effects follow-up analyses with biobehavioral data showed that all patients responded with significant psychological distress at recurrence diagnosis, but thereafter only the intervention arm improved (P values < 0.023). Immune indices were significantly higher for the intervention arm at 12 months (P values < 0.017).Conclusions: Hazards analyses augment previous findings in showing improved survival for the intervention arm after recurrence. Follow-up analyses showing biobehavioral advantages for the intervention arm contribute to our understanding of how improved survival was achieved. Clin Cancer Res; 16(12); 3270-8. ©2010 AACR.Meta-analyses suggest that stress-related psychosocial factors (1) and lower health-related quality of life (2) are associated with poorer cancer survival, with a 13% increase in the hazard ratio (HR) in studies of breast cancer patients (1). In 1994 a randomized controlled trial, the Stress and Immunity Breast Cancer Project (SIBCP), was designed to test the hypothesis that newly diagnosed breast cancer patients receiving a psychological intervention would have a reduced risk of recurrence and breast cancer death compared with patients who were only assessed. A conceptual model guided the development of the clinical trial. The Biobehavioral Model of Cancer Stress and Disease Course (3) proposes that psychological stress leads to disruptions in quality of life, health behaviors, and immunity, which in turn contribute to poorer disease outcomes. It was hypothesized that an intervention designed to reduce emotional distress and improve social adjustment, health behaviors, and adherence might also improve immunity and disease course. Analyses showed that positive intervention effects were achieved across the psychological and immune outcomes at 4 months (4)...

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Section: Discussionmentioning

confidence: 99%

Biobehavioral, Immune, and Health Benefits following Recurrence for Psychological Intervention Participants

Andersen

Thornton

Shapiro

et al. 2010

Clinical Cancer Research

146

107

View full text Add to dashboard Cite

show abstract

“…High levels of NKCA in cancer patients correlate with a good prognosis (Gonzales, et al, 1998;Koda, et al, 1997;Liljefors, et al, 2003;Nakamura, et al, 2000;Seo and Tokura, 1999;Taketomi, et al, 1998). Impaired NKCA correlates with invasiveness of human malignancy (Levy, et al, 1984) and reduced NKCA is a significant prognostic indicator of lymphatic involvement, serosal invasion, lymph node metastatic disease and a poorer survival rate (Takeuchi, et al, 2001). NK cell infiltration into primary tumors is associated with fewer metastases to the lymph nodes and less lymphatic invasion (Koda et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer

Witek-Janusek

Albuquerque

Chroniak

et al. 2008

Brain, Behavior, and Immunity

398

324

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This investigation used a non-randomized controlled design to evaluate the effect and feasibility of a mindfulness based stress reduction (MBSR) program on immune function, quality of life (QOL), and coping in women recently diagnosed with breast cancer. Early stage breast cancer patients, who did not receive chemotherapy, self-selected into an 8-week MBSR program or into an assessment only, control group. Outcomes were evaluated over time. The first assessment was at least 10 days after surgery and prior to adjuvant therapy, as well as before the MBSR start-up. Further assessments were mid-MBSR, at completion of MBSR, and at 4-weeks post MBSR completion. Women with breast cancer enrolled in the control group (Non-MBSR) were assessed at similar times. At the first assessment (i.e., before MBSR start), reductions in peripheral blood mononuclear cell NK cell activity (NKCA) and IFN gamma production with increases in IL-4, IL-6, and IL-10 production and plasma cortisol levels were observed for both the MBSR and Non-MBSR groups of breast cancer patients. Over time women in the MBSR group re-established their NKCA and cytokine production levels. In contrast, breast cancer patients in the Non-MBSR group exhibited continued reductions in NKCA and IFN gamma production with increased IL-4, IL-6, and IL-10 production. Moreover, women enrolled in the MBSR program had reduced cortisol levels, improved QOL, and increased coping effectiveness compared to the Non-MBSR group. In summary, MBSR is a program that is feasible for women recently diagnosed with early stage breast cancer and the results provide preliminary evidence of beneficial effects of MBSR on immune function, QOL, and coping effectiveness.

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“…NK cells are relevant to cancer control, protecting against tumor initiation, growth and metastasis in a variety of ways (Vivier et al, 2011). Higher levels of NKCA in cancer patients correlate with a better prognosis (Gonzales et al, 1998; Koda et al, 1997; Liljefors et al, 2003; Nakamura et al, 2000; Seo and Tokura, 1999; Taketomi et al, 1998); while impaired NKCA correlates with increased tumor invasiveness (Ishigami et al, 2000; Konjević et al, 2001; Levy et al, 1984; Takeuchi et al, 2001; Villegas et al, 2002). NK cells are especially important during critical times marked by risk for tumor dissemination, such as after surgery and during the early recovery phase after completion of adjuvant therapy (i.e.…”

Section: Discussionmentioning

confidence: 99%

Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer

Janusek

Tell

Albuquerque

et al. 2013

Brain, Behavior, and Immunity

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Women respond differentially to the stress-associated with breast cancer diagnosis and treatment, with some women experiencing more intense and/or sustained behavioral symptoms and immune dysregulation than others. Childhood adversity has been identified to produce long-term dysregulation of stress response systems, increasing reactivity to stressors encountered during adulthood. This study determined whether childhood adversity increased vulnerability for more intense and sustained behavioral symptoms (fatigue, perceived stress, and depressive symptoms), poorer quality of life, and greater immune dysregulation in women (N=40) with breast cancer. Evaluation was after breast surgery and through early survivorship. Hierarchical linear modeling was used to examine intra-individual and inter-individual differences with respect to initial status and to the pattern of change (i.e. trajectory) of outcomes. At initial assessment, women exposed to childhood emotional neglect/abuse had greater perceived stress, fatigue, depressive symptoms and poorer quality of life, as well as lower natural killer cell activity (NKCA). Although these outcomes improved over time, women with greater childhood emotional neglect/abuse exhibited worse outcomes through early survivorship. No effect was observed on the trajectory for these outcomes. In contrast, childhood physical neglect predicted sustained trajectories of greater perceived stress, worse quality of life, and elevated plasma IL-6; with no effect observed at initial assessment. Thus, childhood adversity leaves an enduring imprint, increasing vulnerability for behavioral symptoms, poor quality of life, and elevations in IL-6 in women with breast cancer. Further, childhood adversity predisposes to lower NKCA at a critical time when this immune-effector mechanism is most effective at halting nascent tumor seeding.

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Stage-related decrease in natural killer cell activity in untreated patients with mycosis fungoides

Cited by 17 publications

References 6 publications

Biobehavioral, Immune, and Health Benefits following Recurrence for Psychological Intervention Participants

Biobehavioral, Immune, and Health Benefits following Recurrence for Psychological Intervention Participants

Effect of mindfulness based stress reduction on immune function, quality of life and coping in women newly diagnosed with early stage breast cancer

Childhood adversity increases vulnerability for behavioral symptoms and immune dysregulation in women with breast cancer

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