Staging computed tomography of the thorax for nasopharyngeal carcinoma

Leung, Sing Fai; Cheung, H. T. Andrew; Teo, Peter M.L.; Lam, Wynnie W. M.

doi:10.1002/1097-0347(200007)22:4<369::aid-hed9>3.0.co;2-2

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Conventional work-up (CWU) with chest radiography, abdominal ultrasonography, and skeletal scintigraphy is routinely performed for detecting distant metastases (4). On the other hand, CT of the thorax is not generally recommended because of its very low yield (5). Although widely available and affordable, these techniques have important limitations (6).…”

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confidence: 99%

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Liu¹,

Lin²,

Chang³

et al. 2007

Journal of Nuclear Medicine

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Conventional work-up (CWU) with chest radiography, abdominal ultrasonography, and skeletal scintigraphy has limited value in M staging of nonkeratinizing nasopharyngeal carcinoma (NPC). Our aim was to evaluate whether 18 F-FDG PET could replace CWU by comparing their diagnostic efficacies. Methods: Patients with histologically proven nonkeratinizing NPC and no prior treatment were prospectively enrolled. All study participants underwent CWU and 18 F-FDG PET for primary M staging. Distant metastasis was considered to be present if there was any reliable evidence identified within 1 y after diagnosis. The comparative diagnostic efficacies of 18 F-FDG PET, CWU, and the combination of 18 F-FDG PET and CWU (PET1CWU) were evaluated using the areas under the receiver-operating-characteristic (ROC) curves. Results: Sixty-one (20.3%) of 300 eligible patients were found to have distant metastases. On a patient-based analysis, 18 F-FDG PET was found to be more effective than CWU (P , 0.001), whereas it was equally effective with PET1CWU (P 5 0.130). On region-based analyses, 18 F-FDG PET was more effective than skeletal scintigraphy and chest radiography for detecting bone metastases (P , 0.001) and chest metastases (P , 0.001), respectively. 18 F-FDG PET and abdominal ultrasound were equally effective for detecting hepatic metastases (P 5 0.127). On region-based analyses, the combination of 18 F-FDG PET and CWU did not yield any noticeable increase in diagnostic efficacy. Conclusion: 18 F-FDG PET can replace CWU in primary M staging of nonkeratinizing NPC.

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confidence: 99%

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Liu¹,

Lin²,

Chang³

et al. 2007

Journal of Nuclear Medicine

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“…The skeletal system, the thorax and the liver are the most frequent sites of distant metastatic spread in NPC [11]. The orderly spread of nodal metastases in the cephalad-caudal direction in NPC [12] suggests the possibility that the superior mediastinal and axillary nodes could be the next station for lymphatic spread after supraclavicular nodal metastases [13]. Recurrence and metastasis are commonly seen after the initial treatment of advanced NPC, which can lead to the failure of first-cycle radiotherapy in up to 25% of cases.…”

Section: Discussionmentioning

confidence: 99%

Unsuspected axillary lymph node metastasis of nasopharyngeal and cervical cancer on 18FDG PET/CT: a case report

Kang

2016

Nucl. Med. Rev.

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Axillary lymph node metastasis (ALNM) from cancer except breast cancer is rare. Whole body 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) that simultaneously offers anatomic and metabolic information is widely used and has become an effective modality in many clinical fields, especially oncology, and also may detect an unexpected metastasis. We report two cases of ALMN of nasopharyngeal and cervical cancer that was detected on whole body PET/CT.

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“…In both cases, the lesions were identified on chest X-ray prior to scanning. Another study reported that staging CT of the thorax had a very low yield in 44 nasopharyngeal carcinoma patients with neck metastases 15 …”

Section: Discussionmentioning

confidence: 99%

Initial staging examinations for head and neck squamous cell carcinoma: are they appropriate?

et al. 2009

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Staging computed tomography of the thorax for nasopharyngeal carcinoma

Cited by 8 publications

References 23 publications

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

18F-FDG PET Can Replace Conventional Work-up in Primary M Staging of Nonkeratinizing Nasopharyngeal Carcinoma

Unsuspected axillary lymph node metastasis of nasopharyngeal and cervical cancer on 18FDG PET/CT: a case report

Initial staging examinations for head and neck squamous cell carcinoma: are they appropriate?

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