Staging of Pelvic Lymph Nodes in Neoplasms of the Bladder and Prostate by Positron Emission Tomography with 2-[&lt;sup&gt;18&lt;/sup&gt;F]-2-Deoxy-&lt;i&gt;D&lt;/i&gt;-Glucose

Heicappell, R.; Müller-Mattheis, V.; Reinhardt, Martin; Vosberg, H.; Gerharz, Claus Dieter; Müller‐Gärtner, Hans‐Wilhelm; Ackermann, R.

doi:10.1159/000020052

Cited by 112 publications

(47 citation statements)

References 16 publications

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“…As a metabolic and anatomic diagnostic tool, PET/CT with 18 F-FDG has the ability to overcome the limitations of stand-alone PET and conventional imaging modalities leading to changes in patient management (10). Our results show that delayed 18 F-FDG PET/CT images after diuretic and oral hydration can detect hypermetabolic lesions in the bladder walls with high-quality images.…”

Section: Discussionmentioning

confidence: 73%

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18F-FDG PET/CT Delayed Images After Diuretic for Restaging Invasive Bladder Cancer

Anjos¹,

Etchebehere²,

Ramos³

et al. 2007

Journal of Nuclear Medicine

159

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PET with 18 F-FDG has been considered of limited value for detection of bladder cancer because of the urinary excretion of the tracer. The purpose of this study was to investigate the role of PET/CT in the detection and restaging of bladder cancer using furosemide and oral hydration to remove the excreted 18 F-FDG from the bladder. Methods: Seventeen patients with bladder cancer (11 without cystectomy, 6 with total cystectomy and urinary diversion) underwent 18 F-FDG PET/CT from head to the upper thighs 60 min after the intravenous injection of 370 MBq of 18 F-FDG. Additional pelvic images were acquired 1 h after the intravenous injection of furosemide and oral hydration. PET/CT findings were confirmed by MRI, cystoscopy, or biopsy. Results: PET/CT was able to detect bladder lesions in 6 of 11 patients who had not undergone cystectomy. These images changed the PET/ CT final reading in 7 patients: Recurrent bladder lesions were detected in 6 patients, pelvic lymph node metastases in 2 patients, and prostate metastasis in 1. This technique overcame the difficulties posed by the urinary excretion of 18 F-FDG. Hypermetabolic lesions could be easily detected by PET and precisely localized in the bladder wall, pelvic lymph nodes, or prostate by CT. Seven of 17 patients (41%) were upstaged only after delayed pelvic images. Conclusion: Detection of locally recurrent or residual bladder tumors can be dramatically improved using 18 F-FDG PET/CT with delayed images after a diuretic and oral hydration.

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Section: Discussionmentioning

confidence: 73%

“…A small number of studies have been done with 18 F-FDG PET in bladder cancer (9)(10)(11) and, to the best of our knowledge, none have been undertaken so far with PET/CT. Several investigators have considered 18 F-FDG PET of no utility in the detection of localized bladder cancers and perivesical lymph nodes (12)(13)(14)(15).…”

mentioning

confidence: 99%

18F-FDG PET/CT Delayed Images After Diuretic for Restaging Invasive Bladder Cancer

Anjos¹,

Etchebehere²,

Ramos³

et al. 2007

Journal of Nuclear Medicine

159

View full text Add to dashboard Cite

show abstract

“…Hasta el año 1999, y utilizando como radiotrazador 18 FDG, se demostró que su capacidad para evidenciar afectación ganglionar en tumores órgano-confinados era baja 14 , lo que descartaba su utilización rutinaria en la práctica clínica 33 . Sin embargo, era ligeramente superior a la TC en el diagnóstico de recidiva en partes blandas 34 y, por ello, más útil en la monitorización de la respuesta al tratamiento 35 .…”

Section: Discussionunclassified

“…Algunos no encontraron ningún tipo de correlación 36,37 , mientras que otros, por el contrario, sí lo demostraban. Se encontró, además, una débil correlación con el PSA, pero que era insuficiente para su aplicación clínica 33 .…”

Section: Discussionunclassified

Valor de la PET en la recurrencia del cáncer de próstata con PSA < 5 ng/ml

Zuazu

Rodríguez

Mayans³

et al. 2009

Actas Urol Esp

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“…In one patient, a tumor focus was detected within the bladder with accompanying bone metastases, which was negative on bone scan. In the remaining 3 cases, intense accumulation of the tracer within the bladder hampered the 11 C-choline metastases (31). More recently, in a study involving 47 evaluable patients, 18 F-FDG PET/CT detected more malignant disease than conventional CT/MRI in 40% of patients and demonstrated overall sensitivity and specificity of 87% and 88% respectively.…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%