Stagnation Pressure in Liquid Needle-Free Injection: Modeling and Experimental Validation

Chen, Kai; Zhou, Hua; Ji, Li; Cheng, Gary J.

doi:10.2174/2210303111101020097

Cited by 11 publications

(20 citation statements)

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“…Fig. ( 3 ) is a general mathematical model of a spring-powered NFID first proposed by Sander and Baker [ 14 ] and further improved by Chen et al [ 13 ]. The model is able to predict the injection pressure (stagnation pressure of the impinging jet), determine the penetration capability.…”

Section: Physical Model and Numerical Calculationmentioning

confidence: 99%

“…The friction force can be achieved by the following expression, according to analysis of the same author [ 13 ]:…”

Section: Physical Model and Numerical Calculationmentioning

confidence: 99%

“…P c is the pressure due to the ring compression in the absence of liquid. From finite element analysis, the value of P c is about 3.5MPa [ 13 ].…”

Section: Physical Model and Numerical Calculationmentioning

confidence: 99%

“…It is reported that the maximum injection pressure needs to reach a threshold before the jet is able to erode and penetrate into the skin [ 12 ]. The authors have developed a quasi-steady physical model to calculate the dynamic injection pressure for a given driving force [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Design and Analysis of a Continuous Split Typed Needle-Free Injection System for Animal Vaccination

Chen

Pan

Liu

2017

TOBEJ

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Background:Liquid needle-free injection devices (NFIDs) employ a high-velocity liquid jet to deliver drugs and vaccine through transdermal injection. NFIDs for animal vaccination are more complicated than those used for human beings for their much larger and more flexible power sources, as well as rapid, repetitive and continuous injection features.Method:In the paper, spring-powered NFID is designed for animal vaccine injection. For convenience, the device is a split into a power source and handheld injector. A mathematical model is proposed to calculate the injection pressure, taking into the account pressure loss and the strain energy loss in the bendable tube due to elastic deformation. An experimental apparatus was build to verify the calculation results.Results and Conclusion:Under the same system conditions, the calculation results of the dynamic injection pressure match the experimental results. It is found that the bendable tube of the split typed NFID has significant impact on the profile of the injection pressure. The initial peak pressure is less than the initial peak pressure of NFID without bendable tube, and there is occurrence time lag of the peak pressure. The mathematical model is the first attempt to reveal the relationship between the injection pressure and the system variables of split typed NFID.

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Section: Physical Model and Numerical Calculationmentioning

confidence: 99%

“…The friction force can be achieved by the following expression, according to analysis of the same author [ 13 ]:…”

Section: Physical Model and Numerical Calculationmentioning

confidence: 99%

“…P c is the pressure due to the ring compression in the absence of liquid. From finite element analysis, the value of P c is about 3.5MPa [ 13 ].…”

Section: Physical Model and Numerical Calculationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Design and Analysis of a Continuous Split Typed Needle-Free Injection System for Animal Vaccination

Chen

Pan

Liu

2017

TOBEJ

Self Cite

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“…It is reported that the maximum injection pressure in the initial moment needs to reach above a threshold before the jet is able to erode and penetrate into the skin [15]. The authors have developed a quasi-steady physical model to calculate the dynamic injection pressure for a given driving force [16]. By solving the force balance and the mass and energy conservation established separately for driving piston and for injection liquid, Equation (1) was obtained to express the piston movement and the injection pressure as coupled functions of time.…”

Section: The Physical Model and Calculationmentioning

confidence: 99%

A Voice Coil Powered Controllable Micro-Jet Injection System

Chen¹,

Miao²,

Zhao³

2015

JBiSE

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A medical device of micro-jet injection for drug delivery is described in this paper. The device is powered by a Lorentz force driver (or voice coil motor, VCM) and is able to perform pulsed injection through controlling the direction of the current passing through the device. The driving force and the resulting injection pressure are also controllable through control of the current intensity of the VCM. A physical model was established by combining the existing jet injection model with the relationship of the driving force obtained from a finite-element-method (FEM) analysis, and was verified by experimental measurements. The numerical calculation of the physical model reveals the relationship between the injection pressure and the current intensity of VCM under system conditions. In normal cases, the injection dose can be varied. Thus the relationship between the current intensity of VCM and the dose value was numerically obtained under the condition for the maximum injection pressure to be above a threshold value. These results can be used for optimization of the device.

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Experiments and Modeling of Air-Powered Needle-Free Liquid Injectors

Portaro

2015

J. Med. Biol. Eng.

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Liquid jet injectors are biomedical devices used for drug delivery without the use of hypodermic needles. These devices generate a high-speed small-diameter liquid jet of sufficient pressure to penetrate the skin and deliver an appropriate amount of medication. In this study, a detailed investigation on needle-free liquid injection systems powered by compressed air is carried out.Experiments are conducted using a custom-built experimental prototype which makes it possible to vary a number of parameters. The experimental results are used to validate a fluid mechanics model for air-powered needle-free injectors. The model, based on the work of Baker and Sanders

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Stagnation Pressure in Liquid Needle-Free Injection: Modeling and Experimental Validation

Cited by 11 publications

References 0 publications

Design and Analysis of a Continuous Split Typed Needle-Free Injection System for Animal Vaccination

Design and Analysis of a Continuous Split Typed Needle-Free Injection System for Animal Vaccination

A Voice Coil Powered Controllable Micro-Jet Injection System

Experiments and Modeling of Air-Powered Needle-Free Liquid Injectors

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