Stairs instead of elevators at the workplace decreases <scp>PCSK</scp>9 levels in a healthy population

Kamani, Christel H.; Gencer, Baran; Montecucco, Fabrizio; Courvoisier, Delphine S.; Vuilleumier, Nicolas; Meyer, Philippe; Mach, François

doi:10.1111/eci.12480

Cited by 38 publications

(24 citation statements)

References 32 publications

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“…Therefore, the investigators have considered that exercise is likely to affect LDL-C by modulating PCSK9. Kamani et al [72] found a significant decrease in mean PCSK9 levels and mean LDL-C levels in volunteers after 3 months exercise, and concluded that daily exercise is independently associated with a decrease in PCSK9 levels over time. Rideout et al [73] used C57BL/6 mice as a model, and feed them with high-fat diet, then make them do aerobic exercise.…”

Section: Aerobic Exercise With Lipids and Lipoproteinsmentioning

confidence: 99%

Effects of aerobic exercise on lipids and lipoproteins

2017

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Dyslipidemia is the risk of cardiovascular disease, and their relationship is clear. Lowering serum cholesterol can reduce the risk of coronary heart disease. At present, the main treatment is taking medicine, however, drug treatment has its limitations. Exercise not only has a positive effect on individuals with dyslipidemia, but can also help improve lipids profile. This review is intending to provide information on the effects of exercise training on both tranditional lipids, for example, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides and new lipids and lipoproteins such as non-high-density lipoprotein cholesterol, and postprandial lipoprotein. The mechanisms of aerobic exercise on lipids and lipoproteins are also briefly described.

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Section: Aerobic Exercise With Lipids and Lipoproteinsmentioning

confidence: 99%

Effects of aerobic exercise on lipids and lipoproteins

2017

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“…Stair climbing uses 8–10 times the energy requirements of the resting state, which makes stair climbing a vigorous daily PA [13,14,15]. The health benefits of regular stair climbing have been reported, including increased aerobic capacity [16,17], improved lipid profiles [18,19], and fitness and body composition [20]. Regular stair use was associated with lower risk of stroke in men who climbed 20–34 floors per week [21], and reduced risk of lung cancer [22].…”

Section: Introductionmentioning

confidence: 99%

Promoting Stair Climbing as an Exercise Routine among Healthy Older Adults Attending a Community-Based Physical Activity Program

Hongu

Shimada

Miyake

et al. 2019

Sports

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Stair climbing provides a feasible opportunity for increasing physical activity (PA) in daily living. The purpose of this study was to examine the daily walking and stair-climbing steps among healthy older adults (age: 74.0 ± 4.9 years; Body Mass Index (BMI): 22.3 ± 2.5 kg/m2). Participants (34 females and 15 males) attended a weekly 6-month community-based PA program. During the entire program period, daily walking and stair-climbing steps were recorded using a pedometer (Omron, HJA-403C, Kyoto, Japan). Before and after the 6-month program, height, body weight and leg muscle strength were assessed. After the 6-month program, the mean walking and stair-climbing steps in both women and men increased significantly (p ≤ 0.01). Daily stair-climbing steps increased about 36 steps in women and 47 steps in men. At the end of 6 months, only male participants had significant correlation between the number of stair steps and leg muscle strength (r = 0.428, p = 0.037). This study reported that healthy older adults attending the community-based PA program had regular stair-climbing steps during daily living. Promoting stair climbing as an exercise routine was feasible to increase their walking and stair-climbing steps.

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“…Importantly, statins upregulate more efficiently PCSK9 mRNA levels than those of the LDLR (Dubuc et al, 2004), rationalizing the poor incremental LDL-c decreases with increasing statin doses. Mediterranean diet (Richard et al, 2012) and exercise (Kamani et al, 2015) reduce circulating levels of PCSK9, whereas high-fat or fructose-rich diets increase the levels of PCSK9 (for a general review see Cui et al, 2015).…”

Section: Role Of Pcsk9 In Inflammation Sepsis and Viral Infectionsmentioning

confidence: 99%

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9

et al. 2016

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The secretory proprotein convertase (PC) family comprises nine members, as follows: PC1/3, PC2, furin, PC4, PC5/6, paired basic amino acid cleaving enzyme 4, PC7, subtilisin kexin isozyme 1/site 1 protease (SKI-1/S1P), and PC subtilisin/kexin type 9 (PCSK9). The first seven PCs cleave their substrates at single/paired basic residues and exhibit specific and often essential functions during development and/or in adulthood. The essential SKI-1/S1P cleaves membrane-bound transcription factors at nonbasic residues. In contrast, PCSK9 cleaves itself once, and the secreted inactive protease drags the low-density lipoprotein receptors (LDLR) and very LDLR (VLDLR) to endosomal/lysosomal degradation. Inhibitory PCSK9 monoclonal antibodies are now prescribed to treat hypercholesterolemia. This review focuses on the implication of PCs in cardiovascular functions and diseases, with a major emphasis on PCSK9. We present a phylogeny of the PCs and the analysis of PCSK9 haplotypes in modern and archaic human species. The absence of PCSK9 in mice led to the discovery of a sex- and tissue-specific subcellular distribution of the LDLR and VLDLR. PCSK9 inhibition may have other applications because it reduces inflammation and sepsis in a LDLR-dependent manner. Our present understanding of the cellular mechanism(s) that enables PCSK9 to induce the degradation of receptors is reviewed, as well as the consequences of its key natural mutations. The PCSK9 ongoing clinical trials are reviewed. Finally, how the other PCs may impact cardiovascular disease and the metabolic syndrome, and become relevant targets, is discussed.

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Stairs instead of elevators at the workplace decreases PCSK9 levels in a healthy population

Abstract: Daily physical activity at the work place is independently associated with a decrease in PCSK9 levels over time.

Cited by 38 publications

References 32 publications

Effects of aerobic exercise on lipids and lipoproteins

Effects of aerobic exercise on lipids and lipoproteins

Promoting Stair Climbing as an Exercise Routine among Healthy Older Adults Attending a Community-Based Physical Activity Program

The Proprotein Convertases in Hypercholesterolemia and Cardiovascular Diseases: Emphasis on Proprotein Convertase Subtilisin/Kexin 9

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