Stan odżywienia chorych po transplantacji komórek krwiotwórczych

Kaźmierczak-Siedlecka, Karolina; Piekarska, Agnieszka; Lubieniecka-Archutowska, Ewelina; Bicz, Marcin; Folwarski, Marcin; Makarewicz, Wojciech; Zaucha, Jan Maciej

doi:10.2478/ahp-2019-0001

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…In addition to probiotics, also prebiotics have the ability to modify the intestinal microbiome. They are defined as non-digestible nutrients that favorably affect the human body by selectively stimulating the growth and activity of bacteria living in the large intestine [53]. They are used for the production of short-chain fatty acids (SCFAs), which when produced in the right amount, favorably affect the maintenance of the intestinal barrier.…”

Section: Prebiotics and Probioticsmentioning

confidence: 99%

“…They are used for the production of short-chain fatty acids (SCFAs), which when produced in the right amount, favorably affect the maintenance of the intestinal barrier. Butyric acid, which belongs to the SCFA group, has anti-inflammatory properties and stimulates the process of reconstruction of the intestinal epithelium [53].…”

Section: Prebiotics and Probioticsmentioning

confidence: 99%

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Immunonutritional support as an important part of multidisciplinary anti-cancer therapy

Kaźmierczak-Siedlecka¹,

Daca²,

Folwarski³

et al. 2020

cejoi

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Immunonutrition is one of the most important parts of nutritional treatment in patients with cancer. There are studies which confirm positive effects of using immunonutrition (arginine, glutamine, omega-3 fatty acids, nucleotides, pre-and probiotics) among others on the reduction of the pro-inflammatory cytokines concentrations, shortening of the hospital stay and improvement of the nutritional status. arginine takes part not only in wound healing process, but also it improves body's immunity and reduces the incidence of infections. Glutamine reduces the incidence of acute grade 2 and 3 esophagitis and improves quality of life of gastric cancer patients. omega 3-fatty acids have the ability to inhibit the activity of nF-κb. They also reduce the symptoms of graft-versus-host disease in patients undergoing hematopoietic cell transplantation. nucleotides support the regeneration of intestinal villi. Probiotics play many roles, mainly inhibit the process of carcinogenesis, reduce the incidence of diarrhea and modify intestinal microbiome. however, there are studies indicating the lack of advantages of using immunonutrition compared to standard nutrition. currently, there is no clear evidence for the use of formulae enriched with immunonutrients versus standard oral nutritional supplements exclusively in the preoperative period. This review summarizes the current knowledge about the role of immunonutrition in supporting treatment of cancer diseases.

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Section: Prebiotics and Probioticsmentioning

confidence: 99%

Section: Prebiotics and Probioticsmentioning

confidence: 99%

Immunonutritional support as an important part of multidisciplinary anti-cancer therapy

Kaźmierczak-Siedlecka¹,

Daca²,

Folwarski³

et al. 2020

cejoi

Self Cite

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Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis

Kaźmierczak-Siedlecka

Dvořák

Folwarski

et al. 2020

Cancers

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The association between bacterial as well as viral gut microbiota imbalance and carcinogenesis has been intensively analysed in many studies; nevertheless, the role of fungal gut microbiota (mycobiota) in colorectal, oral, and pancreatic cancer development is relatively new and undiscovered field due to low abundance of intestinal fungi as well as lack of well-characterized reference genomes. Several specific fungi amounts are increased in colorectal cancer patients; moreover, it was observed that the disease stage is strongly related to the fungal microbiota profile; thus, it may be used as a potential diagnostic biomarker for adenomas. Candida albicans, which is the major microbe contributing to oral cancer development, may promote carcinogenesis via several mechanisms, mainly triggering inflammation. Early detection of pancreatic cancer provides the opportunity to improve survival rate, therefore, there is a need to conduct further studies regarding the role of fungal microbiota as a potential prognostic tool to diagnose this cancer at early stage. Additionally, growing attention towards the characterization of mycobiota may contribute to improve the efficiency of therapeutic methods used to alter the composition and activity of gut microbiota. The administration of Saccharomyces boulardii in oncology, mainly in immunocompromised and/or critically ill patients, is still controversial.

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Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation

Kaźmierczak-Siedlecka

Skonieczna-Żydecka

Biliński

et al. 2021

Cancers

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Nowadays, allogenic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy that is mainly recommended for hematologic malignancies. However, complications (such as graft-versus-host disease, mucositis, disease relapse, and infections) associated with the HSCT procedure contribute to the development of gut microbiota imbalance, gut-barrier disruption, and increased intestinal permeability. In the present narrative review, the crosstalk between gut microbiota products and intestinal homeostasis is discussed. Notably, gut-microbiota-related aspects have an impact on patients’ clinical outcomes and overall survival. In accordance with the most recent published data, gut microbiota is crucial for the treatment effectiveness of many diseases, not only gastrointestinal cancers but also hematologic malignancies. Therefore, it is necessary to indicate a therapeutic method allowing to modulate gut microbiota in HSCT recipients. Currently, fecal microbiota transplantation (FMT) is the most innovative method used to alter/restore gut microbiota composition, as well as modulate its activity. Despite the fact that some previous data have shown promising results, the knowledge regarding FMT in HSCT is still strongly limited, except for the treatment of Clostridium difficile infection. Additionally, administration of prebiotics, probiotics, synbiotics, and postbiotics can also modify gut microbiota; however, this strategy should be considered carefully due to the high risk of fungemia/septicemia (especially in case of fungal probiotics).

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Stan odżywienia chorych po transplantacji komórek krwiotwórczych

Cited by 3 publications

References 37 publications

Immunonutritional support as an important part of multidisciplinary anti-cancer therapy

Immunonutritional support as an important part of multidisciplinary anti-cancer therapy

Fungal Gut Microbiota Dysbiosis and Its Role in Colorectal, Oral, and Pancreatic Carcinogenesis

Gut Microbiome Modulation and Faecal Microbiota Transplantation Following Allogenic Hematopoietic Stem Cell Transplantation

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