Stand-Alone CuFeSe2 (Eskebornite) Nanosheets for Photothermal Cancer Therapy

Abstract

Two-dimensional CuFeSe2 nanosheets have been successfully obtained via solution-phase synthesis using a sacrificial template method. The high purity was confirmed by X-ray diffraction and the two-dimensional morphology was validated by transmission electron microscopy. The intense absorption in the 400–1400 nm region has been the basis for the CuFeSe2 nanosheets’ photothermal capabilities testing. The colloidal CuFeSe2 (CFS) nanosheets capped with S2− short ligands (CFS-S) exhibit excellent biocompatibility in cell culture studies and strong photothermal effects upon 808 nm laser irradiation. The nanosheets were further loaded with the cancer drug doxorubicin and exposed to laser irradiation, which accelerated the release of doxorubicin, achieving synergy in the therapeutic effect.

Numerical Simulation of Enhancement of Superficial Tumor Laser Hyperthermia with Silicon Nanoparticles

“…Recently, various inorganic metallic compounds were tested for their effectiveness as thermal coupling agents. In [102], CuFeSe 2 nanosheets with a mean hydrodynamic diameter of 200 nm were experimentally shown to be able to heat water to 30 • C within 600 s. In [103], palladium hydride nanoparticles suspended in water gained additional heating at 10 • C during 180 s at NIR laser power of 154 mW. However, they require a sophisticated fabrication technique, while the pulsed laser ablation of silicon nanostructures in liquids seems to be a promising, scalable technology.…”

Green Synthesis of Ge1−xSnx Alloy Nanoparticles for Optoelectronic Applications

“…The as-synthesized nanoparticles carry surface ligands originated from the synthesis. Various methods for replacing the long-alkyl-chain solvent/stabilizer used in synthesis have been reported [15,[21][22][23][24]. Such methods include the replacement of oleylamine with much shorter atomic S 2-ligands by a solution-phase ligand-exchange process, accomplished by vigorously shaking a mixture of nanoparticles suspended in an adequate solvent (chloroform used herein) and aqueous (NH4)2S.…”

“…The as-synthesized nanoparticles carry surface ligands originated from the synthesis. Various methods for replacing the long-alkyl-chain solvent/stabilizer used in synthesis have been reported [15,[21][22][23][24]. Such methods include the replacement of oleylamine with much shorter atomic S 2− ligands by a solution-phase ligand-exchange process, accomplished by vigorously shaking a mixture of nanoparticles suspended in an adequate solvent (chloroform used herein) and aqueous (NH 4 ) 2 S. The removal of the surface ligands was qualitatively validated by the loss of nanoparticle dispersibility in chloroform and further confirmed by FT-IR analysis, which shows the disappearance of bands centered around 2800-3000 cm −1 ascribed to C-H stretching vibrations of oleylamine (Figure 3b).…”

Pathogen Receptor Membrane-Coating Facet Structures Boost Nanomaterial Immune Escape and Antibacterial Performance

“…Atomic-level exposure of active sites is crucial for the rational design and improved performance of nanomaterials. , Facets are important surface atomic arrangements that affect the interactions between nanomaterials and cells, such as cell uptake and inflammation . Facets also have distinct energy band structures, and the holes and electrons generated on each facet exhibit different redox abilities. − Thus, the exposure of different facets has been hypothesized as a way to tune the photothermal properties and enzyme-mimetic activities of nanomaterials. Therefore, the design of facet-dependent nanomaterials is of interest and can be exploited for bacterial treatment.…”

“…As a result of its promising photothermal conversion efficiency, biocompatible CuFeSe 2 has been widely used for photothermal cancer therapy. − As nanozymes, Cu- and Fe-based nanomaterials may regulate intracellular oxidative stress and contribute to bacterial cell lysis. , As illustrated in Scheme , we prepared (100)- and (112)-faceted CuFeSe 2 to tune the electronic transfer, photothermal conversion, and enzyme-like activity of nanomaterials. The (100) facet enhances radical generation and shows superior antibacterial capacity compared to the (112) facet.…”