Standardization for sharing and utilization of Chinese genetic resources

Cao, Zhen; Yan-rong, Cao; Ma, Lina; Peng, Zuoqi; Xu-huai, HU; Wang, Yuan‐Yuan; Xu, Jiu-Jin; Ma, Xiaosong

doi:10.3724/sp.j.1005.2008.00051

Cited by 26 publications

(40 citation statements)

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“…Ovarian cancer is the third most common gynecological cancer, which is the leading cause of cancer-related death among females in China today (1) . Because of lack of symptoms from this silent disease, ovarian cancer might have spread to the abdomen in about 70% of cases by the time it was detected and, unfortunately, most patients die within 5 years.…”

mentioning

confidence: 99%

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China

Li¹,

Na²,

Kang³

et al. 2008

International Journal of Gynecological Cancer

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p16 is an important tumor suppressor gene, which is inactivated in many kinds of tumors. The common variants of p16 may be associated with the risk of certain tumors development. We analyzed the frequency of two adjacent polymorphisms in p16 exon 3 (540C-->G and 580C-->T) and their haplotype in blood samples from epithelial ovarian cancer (EOC) patients and healthy controls using polymerase chain reaction-restriction fragment length polymorphism. The results showed that the genotype frequency of p16 580C-->T polymorphism was significantly different among histologic subtypes of EOC (P= 0.02). T allele carriers significantly reduced the risk of serous EOC; the adjusted odds ratio was 0.40 (95% CI = 0.19-0.84). There are neither association between p16 540C-->G polymorphism and EOC development, progression, nor association between the haplotypes of two single nucleotide polymorphisms and the tumor development. Our results suggested that the p16 580C-->T polymorphism might affect the individual susceptibility to specific subtypes of EOC. Different types of ovarian cancer might adopt distinct carcinogenetic pathways. However, this result may be further validated in a larger sample of patients.

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mentioning

confidence: 99%

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China

Li¹,

Na²,

Kang³

et al. 2008

International Journal of Gynecological Cancer

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“…The Yiliping, Xitai, Dongtai salt lakes are developed separately in the depressions and bear similar sedimentology and ore-forming materials (Cao and Wu, 2004;Li et al, 2021a). Two main salt layers with the thickness ranging from 10 to 30 m can be recognized in these salt lakes.…”

Section: Geological Settingmentioning

confidence: 99%

Genesis of Neogene Formation Waters in the Central Qaidam Basin: Clues from Hydrochemistry and Stable D‐O‐S‐Sr Isotopes

HAN,

PAN,

et al. 2023

Acta Geologica Sinica (Eng)

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Geological explorations have revealed plentiful Neogene formation waters in the anticlines in the central Qaidam Basin (QB). However, the hydrochemistry and origin of these waters are obscure. In this study, the hydrochemistry and D–O–S–Sr isotopes of these formation waters were determined to study their origin and evolution. The formation waters are enriched in Na–Ca–Cl, and depleted in Mg–K–SO4–HCO3 ions with elevated Li–B–Br–Sr elements. The D–O isotopes approve that the formation waters are originated from weak–evaporated meteoric waters, and experienced water–rock interactions. The ion comparisons and Caexcess–Nadeficit diagrams suggest that solute sources of these waters include the evaporite dissolution, water–rock interaction, minor residual lake brines. Bacterial sulfate reduction and water–rock interactions are supported by the high S–Sr isotopes. The enriched Li–B–Br–Sr concentrations of these waters are in accord with the high geochemical background values of the QB. The genesis of the formation waters can be concluded that meteoric waters from the southern Kunlun Mountains were discharged into the basin, weakly evaporated, and then infiltrated into the Neogene strata through the faults leaching the soluble ions and mixing with residual lake brines, and experienced water‐rock interactions and sulphate reduction process.

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“…However, more robust biobanking activities in China actually began more recently, in about 2005. Accordingly, the more comprehensive Human Genetic Resources Management Regulations (draft) were formulated by the Chinese Human Genetic Resources Management Office in 2012, 3 which was established under the MoST as well.…”

Section: Introductionmentioning

confidence: 99%

Chinese Biobanking Initiatives

Gan

Wang²,

Song

et al. 2015

Biopreservation and Biobanking

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Due to the requirement for comprehensive clinical research efforts in China, the importance of biobanking in modern clinical research is outlined in this overview. Hospitals, universities, and research institutes have been well organized as fundamental resources for Chinese biobanking initiatives and the resulting bio-sample collections. Here, a brief history and time line of development of biobanking in China will be introduced, as well as strategic designs for future biobanking development.

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Standardization for sharing and utilization of Chinese genetic resources

Cited by 26 publications

References 0 publications

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China

p16(CDKN2) gene polymorphism: association with histologic subtypes of epithelial ovarian cancer in China

Genesis of Neogene Formation Waters in the Central Qaidam Basin: Clues from Hydrochemistry and Stable D‐O‐S‐Sr Isotopes

Chinese Biobanking Initiatives

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